KRAS IN-44
KRAS IN-44 (Compound S2C2M2) is a PDE6D degrader. KRAS IN-44 inhibits PDE6D-dependent KRAS trafficking and KRAS downstream signaling pathways. KRAS IN-44 down-regulates EGF-induced the phosphorylation of PI3K, AKT, and mTOR. KRAS IN-44 increases Apoptosis. KRAS IN-44 has antitumor activity against hepatoblastoma.
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- Formel: C93H113Cl3F3N15O17
- Molecular Weight:1876.34
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
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PDE6D |
Chemical Information
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Molecular Weight 1876.34
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Formel C93H113Cl3F3N15O17
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SMILES
ClC1=CC=C([C@@H]2[C@H](C3=CC=C(Cl)C=C3)N(C(N4CC(N(CC(NCCOCCOCCN5C=C(COCC(NC(CCNC(CC[C@@H](C)[C@]6([H])[C@]([C@@H](O)C[C@@]7([H])[C@@]8([H])[C@H](O)C[C@@]9([H])[C@]7(C)CC[C@@H](O)C9)(C)[C@@]8([H])CC6)=O)=O)C(NCCNC(C%10=NC=CC(OC%11=CC=C(NC(NC%12=CC=C(Cl)C(C(F)(F)F)=C%12)=O)C=C%11)=C%10)=O)=O)N=N5)=O)CC4)=O)=O)C(C%13=CC=C(OC)C=C%13OC(C)C)=N2)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
KRAS IN-44 Related Classifications
HY-174379 Related Classifications
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