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Cat. No.: HY-146444

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Anticancer agent 56

Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with agent-likeness properties, possessing anticancer activity against several cancer cell lines (IC₅₀<3 μM). Anticancer agent 56 induces cell cycle arrest at G2/M phase and triggers mitochondrial apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9.

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CAS No.: 2241915-59-1
Formule: C₂₀H₁₈ClN₃O₃
Masse moléculaire:383.83

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Anticancer agent 56 Chemical Structure

CAS No.: 2241915-59-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

IC₅₀: 0.64 ± 0.02 μM in Leukemia RPMI-8226, 0.96 ± 0.04 μM in Leukemia SR, 0.84 ± 0.07 μM in Leukemia K-562, 0.69 ± 0.01 μM in Melanoma M14, 0.24 ± 0.01 μM in Breast MCF7, 0.26 ± 0.01 μM in Colon HCT116, 2.95 ± 0.14 μM in Prostate PC3^[1]

Voir tous les produits spécifiques à Isoform Bcl-2 Family :

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Cellular Effect

Cell Line	Type	Value	Description	References
CCD-18Co	IC₅₀	17.15 μM Compound: 4d	Cytotoxicity against human CCD-18Co cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human CCD-18Co cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
HCT-116	IC₅₀	0.26 μM Compound: 4d	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
K562	IC₅₀	0.84 μM Compound: 4d	Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
K562	IC₅₀	0.84 μM Compound: 14	Antiproliferative activity against human K562 cells Antiproliferative activity against human K562 cells	[PMID: 38889607]
Leukemia cell	IC₅₀	0.96 μM Compound: 14	Cytotoxicity against human Leukemia cancer cells Cytotoxicity against human Leukemia cancer cells	[PMID: 38889607]
M14	IC₅₀	0.69 μM Compound: 4d	Cytotoxicity against human M14 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human M14 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
MCF-10A	IC₅₀	25 μM Compound: 4d	Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
MCF7	IC₅₀	0.24 μM Compound: 4d	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
PC-3	IC₅₀	2.95 μM Compound: 4d	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
RPMI-8226	IC₅₀	0.64 μM Compound: 4d	Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
RPMI-8226	IC₅₀	0.64 μM Compound: 14	Antiproliferative activity against human RPMI-8226 cells Antiproliferative activity against human RPMI-8226 cells	[PMID: 38889607]
SR	IC₅₀	0.96 μM Compound: 4d	Cytotoxicity against human SR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human SR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]

Chemical Information

CAS No. 2241915-59-1
Masse moléculaire 383.83
Formule C₂₀H₁₈ClN₃O₃
SMILES

COC1=C(C=C(C=C1)/C=C/C(C2=C(N(N=N2)C3=CC=C(C=C3)Cl)C)=O)OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ashour HF, et al. 1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226. Eur J Med Chem. 2020;189:112062. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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Anticancer agent 56

Voir tous les produits spécifiques à Isoform Bcl-2 Family

Voir tous les produits spécifiques à Isoform Caspase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Anticancer agent 56 Related Classifications

HY-146444 Related Classifications