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Cat. No.: HY-150696

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Antitumor agent-72

Antitumor agent-72 (compound 6w) is a potent anticancer agent. Antitumor agent-72 has anticancer activity and induces apoptosis through activation of caspase-3 and cleavage of PARP. Antitumor agent-72 can be used for cancer research.

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CAS No.: 2676942-92-8
Formule: C₂₅H₂₀ClNO₆
Masse moléculaire:465.88

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antitumor agent-72 Chemical Structure

CAS No.: 2676942-92-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Caspase :

Voir tous les produits spécifiques à Isoform PARP :

In Vitro

Antitumor agent-72 (compound 6w) (0-10 µM; 72 h; BxPC3, PC3 and MCF7 cells) has anticancer activity and inhibits cell viability in a dose-dependent manner^[1].
Antitumor agent-72 (compound 6w) (0-10 µM; 24 h; BxPC3 cells) induces apoptosis through activation of caspase-3 and cleavage of PARP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

BxPC3, PC3 and MCF7 cells
Concentration:

0, 0.03, 0.1, 0.3, 1, 3 and 10 µM
Incubation Time:

72 hours
Result:

Inhibited cell viability in BxPC3, PC3 and MCF7 cells with IC₅₀ values of 0.47 µM, 2.68 µM and 1.82 µM, respectively.

Western Blot Analysis^[1]

Cell Line:

BxPC3 cells
Concentration:

0, 0.1, 0.3, 1, 3 and 10 µM
Incubation Time:

24 hours
Result:

Increased caspase-3 activation and PARP cleavage in BxPC3 cells.

Chemical Information

CAS No. 2676942-92-8
Masse moléculaire 465.88
Formule C₂₅H₂₀ClNO₆
SMILES

COC1=CC(O)=C(C(OC)=C1OC)C(C2=CC3=CC=CN3C(C(C4=CC=C(Cl)C=C4)=O)=C2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lee Y, et, al. Generation of a poly-functionalized indolizine scaffold and its anticancer activity in pancreatic cancer cells. Bioorg Chem. 2022 Sep;126:105877. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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Antitumor agent-72

Voir tous les produits spécifiques à Isoform Caspase

Voir tous les produits spécifiques à Isoform PARP

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Antitumor agent-72 Related Classifications

HY-150696 Related Classifications