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Pentamidine

(Synonyms: MP-601205)
9 Cited Publications
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Based on 9 publication(s) in Google Scholar

Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.

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  • Pureté: 97.19%
  • CAS No.: 100-33-4
  • Formule: C19H24N4O2
  • Masse moléculaire:340.42
  • Stockage:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Pentamidine Chemical Structure
    Pentamidine Chemical Structure
  • Experimental Validation Results for Pentamidine
  • Experimental Validation Results for Pentamidine
  • Experimental Validation Results for Pentamidine
  • Experimental Validation Results for Pentamidine
  • Experimental Validation Results for Pentamidine
  • Experimental Validation Results for Pentamidine
CAS No.: 100-33-4
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Cell Proliferation/Viability AssayCell Migration/Invasion AssayWBIn Vivo Efficacy StudyRT-PCRIF
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  • Pentamidine Chemical Structure
    Pentamidine Chemical Structure
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    Pentamidine purchased from MedChemExpress. Usage Cited in: BMC Womens Health. 2022 Nov 24;22(1):470. [Abstract]

    Customer Validation
     Pentamidine (2.5, 5 μM; 24-36 h) reduces cell migration in a dose- and time-dependent manner, in Ishikawa and HEC-1A cells.

  • 1/16

    Pentamidine purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2021 Jul 1;15:2857-2868. [Abstract]

    Customer Validation
     HO8910 cells were seeded in 96-well plates and treated with different concentrations of Pentamidine (0, 1, 2.5, 5.0, 7.5, 15, 20 μmol/L) for 24 hours, with three replicates for each concentration. Cell viability was then assessed after incubation with 20 μL of MTS for 1 hour.

  • 1/16

    Pentamidine purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2021 Jul 1;15:2857-2868. [Abstract]

    Customer Validation
     Scratch healing experiments were performed using DMSO control and Pentamidin-treated HO8910 cells. Representative images were obtained at specified time points at a concentration of 2.5 μmol/L.

  • 1/16

    Pentamidine purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2021 Jul 1;15:2857-2868. [Abstract]

    Customer Validation
     HO8910 and Caov3 cells were treated with different concentrations of Pentamidine (5/10/20 μM) for 24 hours. Cell lysates were collected and analyzed by Western blotting using anti-PTEN antibody. GAPDH was used as an internal control.

  • 1/16

    Pentamidine purchased from MedChemExpress. Usage Cited in: Drug Des Devel Ther. 2021 Jul 1;15:2857-2868. [Abstract]

    Customer Validation
     HO8910 and Caov3 cells were treated with 20 μmol/L Pentamidine for 24 hours. PTEN mRNA levels were detected by RT-PCR and normalized to 18S rRNA levels.

  • 1/16

    Pentamidine purchased from MedChemExpress. Usage Cited in: Molecules. 2020 Apr 23;25(8):1980. [Abstract]

    Customer Validation
     In vivo results for T. brucei mouse model of infection. Mouse survival after treatment with 30 mg/kg pentamidine (solid green line), 15 mg/kg Torin2 (solid black line), 5 mg/kg NVP-BGT226 (dotted black line), or the PBS control (solid blue line) for 5 days.

  • Pentamidine