ST8155AA1
ST8155AA1 is a part of antibody agent conjugates (ADCs) charged with HDAC inhibitor. ST8155AA1 induces α-tubulin, histone H3/H4 acetylation via direct enzymatic inhibition. ST8155AA1 recognizes and binds EGFR, undergoes internalization into EGFR-expressing tumor cells. ST8155AA1 inhibits cancer cell proliferation and exerts activity in mouse tumor models. ST8155AA1 can be used for the research of non-small cell lung cancer.
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- CAS. Nr.: 2247025-63-2
- Formel: C43H62N8O9S
- Molecular Weight:867.07
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Traditional Cytotoxic Agents |
ST8155AA1 specifically binds to EGFR with sub-nanomolar range affinity[1].
ST8155AA1 is efficiently internalized into EGFR-expressing Capan-1, NCI-H1975, and A549 human tumor cells following target binding[1].
ST8155AA1 inhibits HDAC activity in NCI-H1975 human lung carcinoma cells, as evidenced by increased acetylation of alpha-tubulin and histones H3 and H4[1].
ST8155AA1 (6 days) inhibits proliferation of NCI-H1975 and Calu-3 human lung adenocarcinoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude Nu/Nu mice subcutaneously injected with NCI-H1975 cells[1]
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Dosage:50 mg/kg
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Administration:i.p.; once every 4 days; 4 doses
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Result:Exhibited anti-tumor activity.
Showed no change in body weight.
Chemical Information
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CAS. Nr. 2247025-63-2
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Molecular Weight 867.07
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Formel C43H62N8O9S
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SMILES
O=C(O)CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CSCCCCC[C@H](NC([C@H]2CCC(N2)=O)=O)C(NC3=CC=CC=C3)=O)C=C1)=O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ST8155AA1 Related Classifications
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