Referencia número: HY-B0198

Cefaclor

2 Cited Publications

Revisión del cliente

Based on 2 publication(s) in Google Scholar

Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections.

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Pureza: 98.51%
No. CAS: 53994-73-3
Fòrmula: C₁₅H₁₄ClN₃O₄S
Peso molecular:367.81

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Cefaclor Chemical Structure

No. CAS: 53994-73-3

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Ensayo clínico
Chemical Information
Publications (2)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

β-lactam

hOAT1

hPepT1-人肽转运蛋白 1

hPepT2-人肽转运蛋白 2

CD63

BDNF

5-HT Receptor

Ver todos los productos específicos de isoformas Antibiotic :

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Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	8200 μM Compound: Cefaclor	TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing CHO cells TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing CHO cells	[PMID: 10052994]

In Vitro

Cefaclor (0-500 μg/mL, 12-24 h) shows obvious antibacterial activity against 556 Gram-positive and Gram-negative isolates. The MIC values of most strains are lower than 3.1 μg/mL, and the MIC value of Staph. aureus is 1 μg/mL in vitro^[4].
Cefaclor (60/500 μM, 30 min) is mainly transported by hPepT2 and hPepT1 in the MDCK stably transduced cell line overexpressing hOAT1、hPepT1 and hPepT2^[2].
Cefaclor (0.16 mg/mL, 30 min) can induce allergic reactions by directly activating basophils and mast cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cefaclor (200 mg/kg/day, p.o. once a day for 5 days) can cause intestinal flora imbalance in mice, as well as anxiety and depression-like behaviors in mice. These symptoms can be alleviated by Fluoxetine (HY-B0102) or vagotomy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J mice (male, 5 weeks old)^[1]
Dosage:

200 mg/kg/day, once a day for 5 days.
Administration:

p.o.
Result:

Significantly decreased serotonin levels in the hippocampus and BDNF in mice.
Cefaclor-induced gut dysbiosis caused anxiety and depression through the microbiota-gut-blood-brain and the microbiota-gut-vagus nerve-brain pathway.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 53994-73-3
Appearance Solid
Peso molecular 367.81
Fòrmula C₁₅H₁₄ClN₃O₄S
Color Light yellow to yellow
SMILES

O=C(C(N12)=C(Cl)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)O
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Journal Impact Factor

Nat Commun

Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO. [Abstract]

2023 Mar 22;14(1):1594. PMID: 36949052
ACS Environ Au

Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]

2025 Aug 5;5(6):573-582. PMID: 41277996

Solvente y solubilidad

In Vitro:

DMSO : 18.5 mg/mL (50.30 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 3.85 mg/mL (10.47 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7188 mL

13.5940 mL

27.1880 mL

5 mM

0.5438 mL

2.7188 mL

5.4376 mL

10 mM

0.2719 mL

1.3594 mL

2.7188 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 3.33 mg/mL (9.05 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

Protocol 2

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 40 mg/mL (108.75 mM); Suspended solution; Need ultrasonic

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (278 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Joo MK, et al. Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice. Sci Rep. 2023 Sep 19;13(1):15529. [Content Brief]

[2]. Li M, et al. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. [Content Brief]

[3]. Yoo HS, et al. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei Med J. 2014 Nov;55(6):1473-83. [Content Brief]

[4]. Neu HC, et al. Cefaclor: in vitro spectrum of activity and beta-lactamase stability. Antimicrob Agents Chemother. 1978 Apr;13(4):584-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.7188 mL	13.5940 mL	27.1880 mL	67.9699 mL
	5 mM	0.5438 mL	2.7188 mL	5.4376 mL	13.5940 mL
	10 mM	0.2719 mL	1.3594 mL	2.7188 mL	6.7970 mL
DMSO	15 mM	0.1813 mL	0.9063 mL	1.8125 mL	4.5313 mL
	20 mM	0.1359 mL	0.6797 mL	1.3594 mL	3.3985 mL
	25 mM	0.1088 mL	0.5438 mL	1.0875 mL	2.7188 mL
	30 mM	0.0906 mL	0.4531 mL	0.9063 mL	2.2657 mL
	40 mM	0.0680 mL	0.3398 mL	0.6797 mL	1.6992 mL
	50 mM	0.0544 mL	0.2719 mL	0.5438 mL	1.3594 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Cefaclor

2 Cited Publications

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Cefaclor

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Publications Citing Use of MedChemExpress (MCE) Cefaclor

Ver todos los productos específicos de isoformas Antibiotic

Ver todos los productos específicos de isoformas 5-HT Receptor

Actividad biológica

Chemical Information

Publications (2)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Cefaclor Related Classifications

HY-B0198 Related Classifications