Anticancer agent 65
Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells.
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- No. CAS: 2407861-48-5
- Fòrmula: C36H63NO5
- Peso molecular:589.89
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Almacenamiento:
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Actividad biológica
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MMP |
Bcl-2 |
Bax |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.07 μM
Compound: 4c
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Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
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[PMID: 31862444] |
| MCF7 | IC50 |
1.27 μM
Compound: 4c
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Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
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[PMID: 31862444] |
| MGC-803 | IC50 |
6.51 μM
Compound: 4c
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Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
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[PMID: 31862444] |
| PC-3 | IC50 |
5.44 μM
Compound: 4c
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Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
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[PMID: 31862444] |
| SGC-7901 | IC50 |
7.11 μM
Compound: 4c
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Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
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[PMID: 31862444] |
Anticancer agent 65 (compound 4c) increases the expression of Bax and decrease that of Bcl-2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2407861-48-5
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Peso molecular 589.89
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Fòrmula C36H63NO5
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SMILES
C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)OC(C5CCNCC5)=O)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@](C)(O)CCCC(C)(O)C)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 65 Related Classifications
HY-146105 Related Classifications
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