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Referencia número: HY-168863

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FF2049

FF2049 is a selective HDAC PROTAC degrader (DC₅₀ = 257 nM for HDAC1). FF2049 promotes ubiquitination and degradation of HDAC. FF2049 promotes Apoptosis. FF2049 can be used for the research of hematological and solid cancer.
(Pink: HDAC ligand (HY-168864); Blue: FEM1B ligand (HY-168865); Black: linker (HY-Y0966)).

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₃₁H₃₈ClN₇O₇
Peso molecular:656.13

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

FF2049 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica

Descripciòn

FF2049 is a selective HDAC PROTAC degrader (DC₅₀ = 257 nM for HDAC1). FF2049 promotes ubiquitination and degradation of HDAC. FF2049 promotes Apoptosis. FF2049 can be used for the research of hematological and solid cancer^[1]. (Pink: HDAC ligand (HY-168864); Blue: FEM1B ligand (HY-168865); Black: linker (HY-Y0966)).

Ver todos los productos específicos de isoformas PROTACs :

Ver todos los productos específicos de isoformas HDAC :

Chemical Information

Peso molecular 656.13
Fòrmula C₃₁H₃₈ClN₇O₇
SMILES

ONC(CCCCCCNC(C1=CC=C(C=C1)NC(CNC(CN2CCOC3=C2C=CC(N(C(CCl)=O)CCC#N)=C3)=O)=O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Feller F, et al. Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders. J Med Chem. 2025 Jan 13. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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FF2049

Ver todos los productos específicos de isoformas PROTACs

Ver todos los productos específicos de isoformas HDAC

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

FF2049 Related Classifications

HY-168863 Related Classifications