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Referencia número: HY-161710

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XYD129

XYD129 is an effective CBP/p300 PROTAC degrader. XYD129 has antiproliferative activity on MV4-11 cell line (IC ₅₀=0.044 μM). XYD129 can be used for the study of acute myeloid leukemia (AML). (Structure Note: Pink, CBP/p300 ligand 5 (HY-161711); Blue, E3 ligase ligand (HY-41547); Black, Linker (HY-40178)).
(Pink: Epigenetic Reader Domain ligand (HY-161711); Blue: Cereblon ligand (HY-41547); Black: linker (HY-40178)).

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₄₁H₃₉FN₈O₉
Peso molecular:806.79

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

XYD129 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
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- Cellular Effect
Chemical Information
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Referencias
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Actividad biológica

Descripciòn

XYD129 is an effective CBP/p300 PROTAC degrader. XYD129 has antiproliferative activity on MV4-11 cell line (IC ₅₀=0.044 μM). XYD129 can be used for the study of acute myeloid leukemia (AML). (Structure Note: Pink, CBP/p300 ligand 5 (HY-161711); Blue, E3 ligase ligand (HY-41547); Black, Linker (HY-40178))^[1]. (Pink: Epigenetic Reader Domain ligand (HY-161711); Blue: Cereblon ligand (HY-41547); Black: linker (HY-40178)).

Ver todos los productos específicos de isoformas PROTACs :

Ver todos los productos específicos de isoformas Epigenetic Reader Domain :

Ver todos los productos específicos de isoformas Histone Acetyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
KG-1	IC₅₀	0.57 μM Compound: 11c	Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis	[PMID: 38829718]
L02	IC₅₀	>100 μM Compound: 11c	Cytotoxicity against human HL7702 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis Cytotoxicity against human HL7702 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis	[PMID: 38829718]
MOLM-16	IC₅₀	0.007 μM Compound: 11c	Antiproliferative activity against human MOLM16 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis Antiproliferative activity against human MOLM16 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter glo luminescence analysis	[PMID: 38829718]
MV4-11	IC₅₀	0.044 μM Compound: 11c	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 120 hrs by celltiter glo luminescence analysis Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 120 hrs by celltiter glo luminescence analysis	[PMID: 38829718]

Chemical Information

Peso molecular 806.79
Fòrmula C₄₁H₃₉FN₈O₉
SMILES

O=C(C1=CC(C(NC2=C(C(C3=CN(N=C3)C)=CC(CO)=C2)F)=O)=C4N1C=CC(OCC(NCCCCNC5=CC=CC6=C5C(N(C7CCC(NC7=O)=O)C6=O)=O)=O)=C4)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wu T, et al. Discovery of a Promising CBP/p300 Degrader XYD129 for the Treatment of Acute Myeloid Leukemia[J]. Journal of Medicinal Chemistry, 2024. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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XYD129

Ver todos los productos específicos de isoformas PROTACs

Ver todos los productos específicos de isoformas Epigenetic Reader Domain

Ver todos los productos específicos de isoformas Histone Acetyltransferase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

XYD129 Related Classifications

HY-161710 Related Classifications