GABARAPL2 - GABA type A receptor associated protein like 2 Gene

Homo sapiens

Also known as ATG8; GEF2; ATG8C; GEF-2; GATE16; GATE-16

Gene ID: 11345 | Gene type: protein coding

About GABARAPL2

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,566,379-75,577,881 (from NCBI)

This gene has 5 transcripts (splice variants), 268 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 110.1), heart (RPKM 86.3) and 25 other tissues.

Summary

Enables ubiquitin protein ligase binding activity. Involved in negative regulation of proteasomal protein catabolic process and protein localization to endoplasmic reticulum. Located in Golgi membrane and autophagosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

GABARAPL2 Products(1)

mRNA	Protein	Name
NM_007285.7	NP_009216.1	gamma-aminobutyric acid receptor-associated protein-like 2

GABARAPL2 Protein Structure

Atg8

0
100
117 a.a.

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor-associated protein-like 2

GABA(A) receptor-associated protein-like 2

Recombinant GABARAPL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76353	GABARAPL2/GATE-16 Protein, Human (His)	P60520 (M1-F117)	≥95%

Related Diseases

Diseases

Alias

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis	Acanthamoeba Encephalitis
Acanthamoeba Granulomatous Encephalitis	Granulomatous Amebic Encephalitis Due To Acanthamoeba

Warburg Micro Syndrome 3

WARBM3

Micro Syndrome 3

Warburg Micro Syndrome 2

WARBM2

Micro Syndrome 2

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05203	GABARAPL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GABARAPL2	MGD	MGI:1890602
Rattus norvegicus	GABARAPL2	RGD	RGD:620510
Canis familiaris	GABARAPL2	VGNC	VGNC:41047
Felis catus	GABARAPL2	VGNC	VGNC:62415
Macaca mulatta	GABARAPL2	VGNC	VGNC:104727
Bos taurus	GABARAPL2	VGNC	VGNC:29186
Others	GABARAPL2	NCBI

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