Mmp3 - matrix metallopeptidase 3 Gene

Also Known as SL-1; SLN1; Str1; EMS-2; MMP-3; SLN-1; STR-1; Stmy1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17392

About Mmp3

Chromosome 9: 7,445,822-7,455,975 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 501 orthologues, 23 paralogues and is associated with 11 phenotypes. Biased expression in mammary gland adult (RPKM 19.5), subcutaneous fat pad adult (RPKM 2.8) and 2 other tissues.

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein is activated by the removal of an N-temrinal activation peptide to generate a zinc-dependent endopeptidase with a broad range of substrates such as proteoglycans, laminin, fibronectin, elastin, and collagens. This gene is located in a cluster of Other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]

Mmp3 Products (1)

mRNA Protein Name
NM_010809.2 NP_034939.1 stromelysin-1 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
involved in cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
20969476 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
20969476 MGI
involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
20969476 MGI
involved in proteolysis IMP
IMP: Inferred from mutant phenotype
20969476 MGI
acts upstream of or within regulation of cell migration IMP
IMP: Inferred from mutant phenotype
11869290 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
20969476 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
20969476 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp3 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (29 - 88)

Peptidase_M10

Peptidase_M10: pfam00413 (109 - 265)

HX

HX: cd00094 (291 - 478)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
Protein Preferred Names Protein Names

stromelysin-1

  • matrix metalloproteinase 3

  • progelatinase

  • transin-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-12170 Prinomastat 98.41% Phase 3
HY-12170A Prinomastat hydrochloride 98.53% Phase 3
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-15768 Ilomastat Inhibitor 99.14% Phase 2
HY-N0262 Cordycepin 99.80% Phase 2
HY-112160 XL-784 free base Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (54)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13564 Batimastat Inhibitor 98.92% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-113952 Actinonin 98.37% Unkown
HY-103444 ARP-100 Inhibitor ≥99.0% Unkown
HY-N1454 Apigenin-7-glucuronide Inhibitor 99.74% Unkown
HY-N1463 Luteolin 7-O-glucuronide Inhibitor 99.98% Unkown
HY-107394 UK 356618 Inhibitor 98.91% Unkown
HY-108672 NF157 Antagonist 99.13% Unkown
HY-P2185A NFF-3 TFA Chemical 96.32% Unkown
HY-119423 MMP Inhibitor II Inhibitor 99.7% Unkown
HY-15606 Tanaproget Agonist 99.73% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-12168 Tanomastat Inhibitor 99.74% Unkown
HY-107428 PD-166793 Inhibitor 99.21% Unkown
HY-110397G KP-457 (GMP) Inhibitor / Unkown
HY-114418 MMP3 inhibitor 1 Inhibitor 99.03% Unkown
HY-119711 NNGH Inhibitor 99.6% Unkown
HY-19485 XL-784 Inhibitor 98.25% Unkown
HY-N1940 β-Anhydroicaritin Inhibitor 99.69% Unkown
HY-W011085 CP-471474 Inhibitor 99.2% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-114164G Murine Thrombin Activator / Unkown
HY-164826 Acetyl zingerone 99.34% Unkown
HY-13564A Batimastat sodium salt Inhibitor 99.04% Unkown
HY-137370 2-Hexynyl-5′-N-ethylcarboxamidoadenosine 99.39% Unkown
HY-169949 TAK-756 Inhibitor / Unkown
HY-P2166A MMP3 inhibitor 3 TFA Inhibitor / Unkown
HY-107617 PTIQ Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-114164F Canine Thrombin / Unkown
HY-12168B (Rac)-Tanomastat Inhibitor / Unkown
HY-12270S T-5224-d8 / Unkown
HY-125507 F81-1144b Inhibitor / Unkown
HY-152030 Tubulin/MMP-IN-2 / Unkown
HY-153913 MMP-9-IN-7 Inhibitor / Unkown
HY-167825 Barakol / Unkown
HY-183764 COX-2/5-LOX-IN-8 Inhibitor / Unkown
HY-18694 CGS 27023A Inhibitor / Unkown
HY-18694A CGS 27023A free base Inhibitor / Unkown
HY-N16408 Berkeleyamide B Inhibitor / Unkown
HY-N16409 Berkeleyamide C Inhibitor / Unkown
HY-P2089 Dnp-PYAYWMR / Unkown
HY-P2166 MMP3 inhibitor 3 Inhibitor / Unkown
HY-P2185 NFF-3 Chemical / Unkown
HY-P3098 Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 / Unkown
HY-P3202 Matrix metalloproteinase 3 / Unkown
HY-P3699 TNO003 Substrate / Unkown
HY-P4937 NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 / Unkown
HY-RS08548 MMP3 Human Pre-designed siRNA Set A / Unkown
HY-RS08549 Mmp3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08550 Mmp3 Rat Pre-designed siRNA Set A / Unkown
HY-114065 MMP3-IN-4 Inhibitor / Unkown
HY-117464 CM-352 Inhibitor / Unkown
HY-P3699A TNO003 TFA Substrate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp3 NCBI NCBI:4314