Rho - rhodopsin Gene

Also Known as Ops; RP4; Opn2; Noerg1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 212541

Summary

Predicted to enable G protein-coupled photoreceptor activity; retinal binding activity; and spectrin binding activity. Involved in photoreceptor cell maintenance. Acts upstream of or within several processes, including detection of temperature stimulus involved in thermoception; thermotaxis; and visual perception. Located in several cellular components, including photoreceptor inner segment; sperm head plasma membrane; and sperm midpiece. Is expressed in several structures, including brain; eye; and heart. Used to study congenital stationary night blindness autosomal dominant 1 and retinitis pigmentosa 4. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 1; fundus albipunctatus; night blindness; retinitis pigmentosa; and retinitis pigmentosa 4. Orthologous to human RHO (rhodopsin). [provided by Alliance of Genome Resources, Apr 2022]

Rho Products (1)

mRNA Protein Name
NM_145383.2 NP_663358.1 rhodopsin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17881533 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to light stimulus IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within detection of light stimulus IMP
IMP: Inferred from mutant phenotype
11747369 MGI
acts upstream of or within detection of temperature stimulus involved in thermoception IGI
IGI: Inferred from genetic interaction
31924821 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
32960171 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
15976449 MGI
acts upstream of or within photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
22183357 MGI
involved in photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
32312889 MGI
acts upstream of or within phototransduction IMP
IMP: Inferred from mutant phenotype
16723493 MGI
acts upstream of or within podosome assembly IMP
IMP: Inferred from mutant phenotype
15976449 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
10097103 MGI
acts upstream of or within response to light intensity IMP
IMP: Inferred from mutant phenotype
32960171 MGI
acts upstream of or within response to light stimulus IMP
IMP: Inferred from mutant phenotype
16723493 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within rod bipolar cell differentiation IMP
IMP: Inferred from mutant phenotype
32960171 MGI
acts upstream of or within sensory perception of light stimulus IMP
IMP: Inferred from mutant phenotype
16723493 MGI
acts upstream of or within thermotaxis IGI
IGI: Inferred from genetic interaction
31924821 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
22937111 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
10399916 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
10725384 MGI
located in rod photoreceptor outer segment IDA
IDA: Inferred from direct assay
19332056 MGI
located in sperm head plasma membrane IDA
IDA: Inferred from direct assay
31924821 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
31924821 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rhodopsin

  • L opsin

  • LWS opsin

  • long wavelength sensitive opsin

  • opsin 2

  • red opsin

  • rod opsin

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10583 Y-27632 dihydrochloride Inhibitor 99.98% Unkown
HY-10583R Y-27632 dihydrochloride (Standard) Inhibitor 99.99% Unkown
HY-12798 Netarsudil Inhibitor 99.94% Unkown
HY-12798B Netarsudil hydrochloride Inhibitor 99.90% Unkown
HY-B0515 Ibandronate Sodium Monohydrate Inducer 99.89% Unkown
HY-12798A Netarsudil dimesylate 99.90% Unkown
HY-19518 Latanoprostene bunod Control 99.75% Unkown
HY-B0515B Ibandronate Sodium Inducer 99.89% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-109191 Sovesudil Inhibitor 99.91% Phase 3
HY-148808 Zelasudil Inhibitor 99.48% Phase 2
HY-I0400 N-Acetylneuraminic acid 99.95% Phase 1

Pre-clinical Phase

Bioactive Molecules (82)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15392 Chroman 1 Inhibitor 98.97% Unkown
HY-12755 ML141 99.96% Unkown
HY-12646 Rhosin hydrochloride 99.94% Unkown
HY-10583G Y-27632 dihydrochloride (GMP) Inhibitor / Unkown
HY-16563 Narciclasine Activator 99.88% Unkown
HY-17543 ML-323 Inhibitor 99.51% Unkown
HY-12646A Rhosin 98.74% Unkown
HY-13991 CCG-1423 99.88% Unkown
HY-108361 CCG-203971 Inhibitor 99.89% Unkown
HY-104064 1A-116 99.72% Unkown
HY-12649 Y16 Inhibitor 98.12% Unkown
HY-115376 Z62954982 Inhibitor 99.38% Unkown
HY-N6012 (-)-Alkannin Inducer 99.88% Unkown
HY-111458 GSK2643943A Inhibitor 98.79% Unkown
HY-121750 CCG-222740 Inhibitor 99.53% Unkown
HY-134817 USP7-IN-8 Inhibitor 99.04% Unkown
HY-N2438 Methylophiopogonanone B 99.84% Unkown
HY-108518 SB-772077B dihydrochloride Inhibitor 99.33% Unkown
HY-15392A Chroman 1 dihydrochloride Inhibitor 98.13% Unkown
HY-18990 GSK180736A Inhibitor 98.81% Unkown
HY-32951 2-Fluoropyridine-4-boronic acid 99.78% Unkown
HY-112362 3-(4-Pyridyl)indole Inhibitor 99.94% Unkown
HY-N0430A Coptisine Sulfate 99.37% Unkown
HY-111432 CCG-232601 Inhibitor 99.00% Unkown
HY-139170 CAY10746 Inhibitor 98.61% Unkown
HY-117149 MLS000532223 Inhibitor 98.45% Unkown
HY-N0600 Ginsenoside F3 99.84% Unkown
HY-150640 Rho-Kinase-IN-2 Inhibitor 98.80% Unkown
HY-W050122 S-(+)-GABOB 95.0% Unkown
HY-109191A Sovesudil hydrochloride Inhibitor 99.45% Unkown
HY-100270 Rho-Kinase-IN-1 Inhibitor 99.91% Unkown
HY-100062 2,4-Dibromo-5-nitropyridine / Unkown
HY-122011 PF-4950834 Inhibitor 99.60% Unkown
HY-126432 NRL-1049 dihydrochloride Inhibitor 99.20% Unkown
HY-15720B Glycyl H-1152 hydrochloride Inhibitor 99.9% Unkown
HY-126913 Rhodblock 6 Inhibitor 98.94% Unkown
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% Unkown
HY-N0430 Coptisine / Unkown
HY-P2325 Exoenzyme C3, clostridium botulinum Inhibitor / Unkown
HY-118151 Rho-Kinase-IN-3 Inhibitor 99.74% Unkown
HY-103045A CMPD101 hydrochloride Inhibitor / Unkown
HY-107614G 1-Oleoyl lysophosphatidic acid sodium (GMP) Activator / Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-118837 WF-536 Inhibitor / Unkown
HY-120429 SKLB-163 Inducer / Unkown
HY-123345 CRT 0105446 Inhibitor / Unkown
HY-129907 2-AEMP / Unkown
HY-130011 CCG-232964 Inhibitor / Unkown
HY-132184S 5,6-Epoxyeicosatrienoic acid-d11 / Unkown
HY-134913 Rhodblock 1a Inhibitor / Unkown
HY-137638 Sp-5,6-DCl-cBIMPS Activator / Unkown
HY-137638A Sp-5,6-DCl-cBIMPS sodium Activator / Unkown
HY-138147 DCP-Rho1 / Unkown
HY-13991A (S)-CCG-1423 / Unkown
HY-145294 ROCK2-IN-5 Inhibitor / Unkown
HY-171909 Glycerophosphoinositol 4-phosphate / Unkown
HY-171909A Glycerophosphoinositol 4-phosphate disodium / Unkown
HY-172917 Rho GTPase inhibitor 1 Inhibitor / Unkown
HY-173222 P-gp inhibitor 28 Inhibitor / Unkown
HY-180371 NF-115 Inducer / Unkown
HY-182613 NSC-2888 / Unkown
HY-185667 ROCK2-IN-15 Inhibitor / Unkown
HY-D3474 ATTO Rho 101 NHS ester / Unkown
HY-D3475 ATTO Rho 11 NHS ester / Unkown
HY-N10341 Centaureidin Activator / Unkown
HY-P11847 AT1R-agonist-1 / Unkown
HY-P5158 Conopeptide rho-TIA Inhibitor / Unkown
HY-P5467 S6(229-239), Amide, biotinalyted Substrate / Unkown
HY-RS11944 RHO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11951 RHOD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W047432 5-Nitro-1H-indazole-3-carbonitrile Inhibitor / Unkown
HY-W110138 Chloroxoquinoline / Unkown
HY-113225B Guanosine triphosphate tritris solution (100 mM) Inducer 99.40% Unkown
HY-123939 JAK1/3-IN-1 Inhibitor / Unkown
HY-130448 8-iso Prostaglandin F1β / Unkown
HY-158652 (R)-CCG-1423 Inhibitor / Unkown
HY-183451 Y-30141 Inhibitor / Unkown
HY-P10393 ERα17p Inducer / Unkown
HY-P10636 Nictide / Unkown
HY-RS17157 Rho Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22304 Rhod Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23607 Rho Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rho NCBI NCBI:6010