Vegfa - vascular endothelial growth factor A Gene

Also Known as Vpf; Vegf

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22339

Summary

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]

Vegfa Products (10)

mRNA	Protein	Name
NM_001025250.3	NP_001020421.2	vascular endothelial growth factor A isoform 1
NM_001025257.3	NP_001020428.2	vascular endothelial growth factor A isoform 3
NM_001110266.1	NP_001103736.1	vascular endothelial growth factor A isoform 4 precursor
NM_001110267.1	NP_001103737.1	vascular endothelial growth factor A isoform 5 precursor
NM_001110268.1	NP_001103738.1	vascular endothelial growth factor A isoform 6 precursor
NM_001287056.1	NP_001273985.1	vascular endothelial growth factor A isoform 7 precursor
NM_001287057.1	NP_001273986.1	vascular endothelial growth factor A isoform Vegf-A precursor
NM_001287058.1	NP_001273987.1	vascular endothelial growth factor A isoform 9 precursor
NM_001317041.1	NP_001303970.1	vascular endothelial growth factor A isoform Vegf-Ax precursor
NM_009505.4	NP_033531.3	vascular endothelial growth factor A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chemoattractant activity	IDA IDA: Inferred from direct assay	21658587	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26503042	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in VEGF-activated neuropilin signaling pathway	IDA IDA: Inferred from direct assay	21828096	MGI
involved in VEGF-activated neuropilin signaling pathway	IMP IMP: Inferred from mutant phenotype	21658587	MGI
acts upstream of or within angiogenesis	IDA IDA: Inferred from direct assay	10617467	MGI
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	16778080	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	12890722	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	15073147	MGI
acts upstream of or within artery morphogenesis	IMP IMP: Inferred from mutant phenotype	10229225	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	15927453	MGI
acts upstream of or within blood vessel morphogenesis	IDA IDA: Inferred from direct assay	15919073	MGI
acts upstream of or within blood vessel morphogenesis	IGI IGI: Inferred from genetic interaction	15919073	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	16027358	MGI
acts upstream of or within bone trabecula formation	IMP IMP: Inferred from mutant phenotype	22886301	MGI
acts upstream of or within bone trabecula morphogenesis	IMP IMP: Inferred from mutant phenotype	22886301	MGI
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	16251428	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	10229225	MGI
involved in cardiac vascular smooth muscle cell development	IMP IMP: Inferred from mutant phenotype	18093989	MGI
acts upstream of or within cell migration	IDA IDA: Inferred from direct assay	15601856	MGI
acts upstream of or within cell migration	IGI IGI: Inferred from genetic interaction	15601856	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	14722611	MGI
acts upstream of cell-cell adhesion	IGI IGI: Inferred from genetic interaction	24367707	MGI
involved in cellular response to vascular endothelial growth factor stimulus	IGI IGI: Inferred from genetic interaction	24401374	MGI
NOT involved in commissural neuron axon guidance	IDA IDA: Inferred from direct assay	21658587	MGI
involved in commissural neuron axon guidance	IDA IDA: Inferred from direct assay	21658587	MGI
involved in commissural neuron axon guidance	IMP IMP: Inferred from mutant phenotype	21658587	MGI
involved in coronary artery morphogenesis	IMP IMP: Inferred from mutant phenotype	18093989	MGI
involved in coronary vein morphogenesis	IMP IMP: Inferred from mutant phenotype	18093989	MGI
acts upstream of or within dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	17215402	MGI
acts upstream of or within endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24403062	MGI
acts upstream of or within endothelial cell proliferation	IDA IDA: Inferred from direct assay	31698979	MGI
acts upstream of or within epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16251428	MGI
acts upstream of or within epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	12053176	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15927453	MGI
acts upstream of or within eye photoreceptor cell development	IMP IMP: Inferred from mutant phenotype	16251428	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	10229225	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	22886301	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	10229225	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	10229225	MGI
acts upstream of or within lactation	IMP IMP: Inferred from mutant phenotype	17625068	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	12053176	MGI
acts upstream of or within lung vasculature development	IMP IMP: Inferred from mutant phenotype	11169844	MGI
involved in lymph vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	18093989	MGI
acts upstream of lymphangiogenesis	IDA IDA: Inferred from direct assay	20133819	MGI
acts upstream of or within lymphangiogenesis	IGI IGI: Inferred from genetic interaction	19233265	MGI
acts upstream of or within mammary gland alveolus development	IMP IMP: Inferred from mutant phenotype	17625068	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	12890722	MGI
involved in motor neuron migration	IMP IMP: Inferred from mutant phenotype	26503042	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15073147	MGI
acts upstream of or within negative regulation of cell-cell adhesion	IGI IGI: Inferred from genetic interaction	24367707	MGI
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	23863481	MGI
involved in negative regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	21828096	MGI
acts upstream of or within negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	22886301	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22886301	MGI
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	21828096	MGI
acts upstream of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	17215402	MGI
involved in neuron development	IMP IMP: Inferred from mutant phenotype	21828096	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	18093989	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	17050862	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	18772315	MGI
involved in positive chemotaxis	IDA IDA: Inferred from direct assay	21658587	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	21828096	MGI
acts upstream of or within positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	20133819	MGI
NOT involved in positive regulation of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	21658587	MGI
involved in positive regulation of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	21658587	MGI
involved in positive regulation of axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	21658587	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	16291795	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17475663	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	26683794	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15927453	MGI
acts upstream of or within positive regulation of lymphangiogenesis	IDA IDA: Inferred from direct assay	20133819	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IGI IGI: Inferred from genetic interaction	17215402	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	22886301	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	18772315	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	21828096	MGI
acts upstream of or within positive regulation of vascular permeability	IDA IDA: Inferred from direct assay	10617467	MGI
acts upstream of or within post-embryonic camera-type eye development	IMP IMP: Inferred from mutant phenotype	10229225	MGI
acts upstream of or within primitive erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	14729577	MGI
acts upstream of or within regulation of endothelial cell differentiation	IDA IDA: Inferred from direct assay	18772315	MGI
acts upstream of or within regulation of growth	IMP IMP: Inferred from mutant phenotype	10229225	MGI
acts upstream of or within regulation of hematopoietic progenitor cell differentiation	IDA IDA: Inferred from direct assay	18772315	MGI
NOT involved in retinal ganglion cell axon guidance	IDA IDA: Inferred from direct assay	21658587	MGI
involved in retinal ganglion cell axon guidance	IMP IMP: Inferred from mutant phenotype	21658587	MGI
involved in sprouting angiogenesis	IDA IDA: Inferred from direct assay	24401374	MGI
acts upstream of or within surfactant homeostasis	IMP IMP: Inferred from mutant phenotype	12053176	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	10229225	MGI
acts upstream of or within vasodilation	IDA IDA: Inferred from direct assay	31698979	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12975317	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	12053176	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22886301	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
vascular endothelial growth factor A	vascular permeability factor

Recombinant Vegfa Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7312	VEGF164 Protein, Mouse	Q00731-2 (A27-R190)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P7421	VEGF164 Protein, Mouse (P.pastoris)	Q00731-2 (A27-R190)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70761	VEGF164 Protein, Mouse (164a.a, P.pastoris)	Q00731-2 (A27-R190)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72775	VEGF120 Protein, Mouse	Q00731-3 (A27-R146)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78686	VEGF120 Protein, Mouse (HEK293)	AAB22254.1 (A27-R146)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78812	VEGF120 Protein, Mouse (Biotinylated, His-Avi)	Q00731-3 (A27-R146)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78814	VEGF164 Protein, Mouse (Biotinylated, HEK293, His-Avi)	Q00731-2 (A27-R190)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9906	Bevacizumab	Inhibitor	≥99.0%	Unkown
HY-P9906A	Bevacizumab (Anti-VEGFA)	Inhibitor	99.07%	Unkown
HY-P99116	Faricimab	Inhibitor	97.97%	Unkown
HY-P9973	Brolucizumab	Inhibitor	99.90%	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P10284	S7		98.25%	Phase 4
HY-124593	PTC299	Inhibitor	99.71%	Phase 3
HY-B1788	Taurocholic acid		99.83%	Phase 2
HY-N0545	Taurocholic acid sodium	Agonist	99.82%	Phase 2
HY-P3369	Gersizangitide		97.16%	Phase 2
HY-B1788R	Taurocholic acid (Standard)		99.91%	Phase 2

Inhibitory Antibodies (12)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99675	Ivonescimab	Inhibitor	99.13%	Phase 4
HY-P99830	Conbercept	Inhibitor	98.42%	Phase 4
HY-P991097	Pumitamig	Inhibitor	99.6%	Phase 3
HY-P99576	Tarcocimab	Inhibitor	98.35%	Phase 3
HY-P991033	Tovecimig		97.39%	Phase 3
HY-P990082	Suvemcitug	Inhibitor	96%	Phase 3
HY-P991416	BAT5906	Inhibitor	/	Phase 3
HY-P991418	MW02	Inhibitor	/	Phase 3
HY-P99330	Vanucizumab	Inhibitor	95.12%	Phase 2
HY-P991738	LM-299		95.78%	Phase 2
HY-P990689	Zifibancimig	Inhibitor	99.00%	Phase 2
HY-P991417	LYN00101	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10799	EG00229 trifluoroacetate	Antagonist	98.03%	Unkown
HY-117661	SPHINX31	Inhibitor	99.25%	Unkown
HY-B1131	Taurocholic acid sodium salt hydrate		98.51%	Unkown
HY-N2187	Deoxyshikonin		99.96%	Unkown
HY-144707	AK-778-XXMU		99.96%	Unkown
HY-P10831	GNQWFI	Antagonist	99.45%	Unkown
HY-115746	Dimethyl-bisphenol A	Inhibitor	99.78%	Unkown
HY-N7043	Isosilybin A		99.63%	Unkown
HY-N0545R	Taurocholic acid sodium (Standard)	Agonist	97.91%	Unkown
HY-N10336	Notoginsenoside R4		99.90%	Unkown
HY-138647	TGP-377/421	Inhibitor	98.17%	Unkown
HY-W653842	Taurocholic acid-d8 sodium	Agonist	98.83%	Unkown
HY-101931	hVEGF-IN-1	Inhibitor	99.25%	Unkown
HY-182700	NRPa-308	Inhibitor	98.96%	Unkown
HY-P10971	Nef-M1		98.87%	Unkown
HY-124722	OHM1	Inhibitor	/	Unkown
HY-149886	HIF-2α-IN-9	Inhibitor	/	Unkown
HY-163760	ZM-32	Inhibitor	/	Unkown
HY-168560	MMP Inhibitor 4	Inhibitor	/	Unkown
HY-176805	TGP-377		/	Unkown
HY-179350	EG01449 Free acid	Inhibitor	/	Unkown
HY-179350A	EG01449	Inhibitor	/	Unkown
HY-182639	AM9928	Inhibitor	/	Unkown
HY-18333	EG00229	Inhibitor	/	Unkown
HY-N0545S2	Taurocholic acid-d4-1 sodium		/	Unkown
HY-N19872	Mukurozioside IIb		/	Unkown
HY-N19873	Mukurozioside IIa		/	Unkown
HY-P10550	VGB4	Antagonist	/	Unkown
HY-P3990	Coibamide A		/	Unkown
HY-RS15635	VEGFA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-128446	CAY10781	Inhibitor	98.04%	Unkown
HY-174510	Human VEGFA mRNA		/	Unkown
HY-B1788S2	Taurocholic acid-d5		/	Unkown
HY-RS16537	Vegfa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22968	Vegfa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W653893	Taurocholic acid-d5 sodium	Agonist	/	Unkown

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9920A	Ramucirumab (anti-VEGFR)	Antagonist	99.9%	Unkown
HY-P9951A	Ranibizumab (anti-VEGF)	Inhibitor	99.60%	Unkown
HY-P990148	Anti-Mouse VEGF-A Antibody (2G11-2A05)	Inhibitor	97.40%	Unkown
HY-P992139	Valancitug	Inhibitor	97.61%	Unkown
HY-P991625	VX70		/	Unkown
HY-P992323	BI-836880	Inhibitor	/	Unkown
HY-P992511	CS2009	Inhibitor	/	Unkown
HY-P992518	Pumitamig (Mouse IgG2a)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vegfa	NCBI	NCBI:7422