Rock2 - Rho-associated coiled-coil containing protein kinase 2 Gene

Also Known as ROK; ROCK-II

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25537

About Rock2

Primary_assembly 6: 39,679,082-39,774,031 forward strand.mRatBN7.2:CM026979.1

This gene has 4 transcripts (splice variants), 309 orthologues, 5 paralogues and is associated with 9 phenotypes. Biased expression in Heart (RPKM 488.3), Lung (RPKM 32.5) and 9 other tissues.

Summary

Predicted to enable Rho-dependent protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of connective tissue replacement; and positive regulation of cytokine production. Acts upstream of or within Rho protein signal transduction. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and spindle pole centrosome. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; centrosome; and glutamatergic synapse. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Rock2 Products (1)

mRNA Protein Name
NM_013022.2 NP_037154.2 rho-associated protein kinase 2

Rock2 Protein Structure

STKc_ROCK2

STKc_ROCK2: cd05621 (38 - 416)

Smc

Smc: cl34174 (436 - 1100)

ROCK_SBD

ROCK_SBD: cd22250 (855 - 935)

PH_ROCK

PH_ROCK: cd01242 (1207 - 1313)

C1_ROCK2

C1_ROCK2: cd20875 (1306 - 1376)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1473 a.a.
Protein Preferred Names Protein Names

rho-associated protein kinase 2

  • ROKalpha

  • Rho-associated coiled-coil forming kinase 2

  • RhoA - binding serine/threosine kinase alpha (ROK - alpha)

  • p150 ROK-alpha

  • p164 ROCK-2

  • rho-associated, coiled-coil-containing protein kinase 2

  • rho-associated, coiled-coil-containing protein kinase II

  • rhoA-binding kinase 2

Rock2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Rock2 Q62868 MYL12A Homo sapiens P19105
Protein Kinase Assay
21457715
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10583 Y-27632 dihydrochloride Inhibitor 99.98% Unkown
HY-10341 Fasudil Hydrochloride Inhibitor 99.97% Yes
HY-15307 Belumosudil Inhibitor 99.83% Yes
HY-10341A Fasudil Inhibitor 99.98% Yes
HY-15685 Ripasudil Inhibitor 99.95% Unkown
HY-15307A Belumosudil mesylate Inhibitor 99.89% Yes
HY-13911A Hydroxyfasudil hydrochloride Inhibitor 98.88% Unkown
HY-13911 Hydroxyfasudil Inhibitor 98.78% Unkown
HY-10341C Fasudil dihydrochloride Inhibitor 99.98% Yes
HY-10341B Fasudil hydrochloride semihydrate Inhibitor / Unkown
HY-15685A Ripasudil free base Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-109191 Sovesudil Inhibitor 99.91% Phase 3
HY-15720 H-1152 Inhibitor 99.00% Phase 2
HY-15687A SAR407899 Inhibitor 99.67% Phase 2
HY-12659 LX7101 Inhibitor 99.54% Phase 2
HY-16758A Verosudil hydrochloride Inhibitor / Phase 2
HY-16071 AT13148 Inhibitor 99.20% Phase 1

Pre-clinical Phase

Bioactive Molecules (54)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10071 Y-27632 Inhibitor 99.91% Unkown
HY-15392 Chroman 1 Inhibitor 98.97% Unkown
HY-103045 CMPD101 Inhibitor 99.49% Unkown
HY-15556 GSK269962A Inhibitor 99.75% Unkown
HY-15720A H-1152 dihydrochloride Inhibitor 99.47% Unkown
HY-119937 ROCK inhibitor-2 Inhibitor 99.92% Unkown
HY-15755 RKI-1447 Inhibitor 98.02% Unkown
HY-13300 SR-3677 Inhibitor 99.23% Unkown
HY-18713 CRT0066854 Inhibitor 99.54% Unkown
HY-10319 BAY-549 Inhibitor 99.46% Unkown
HY-108518 SB-772077B dihydrochloride Inhibitor 99.33% Unkown
HY-15392A Chroman 1 dihydrochloride Inhibitor 98.13% Unkown
HY-12437 BDP5290 Inhibitor 98.90% Unkown
HY-15556A GSK269962A hydrochloride Inhibitor 99.73% Unkown
HY-167832 PT109 Inhibitor 99.20% Unkown
HY-15687 SAR407899 hydrochloride Inhibitor 99.14% Unkown
HY-16758 Verosudil Inhibitor 98.22% Unkown
HY-162596 NRL-1049 Inhibitor 99.96% Unkown
HY-103620 ROCK2-IN-2 Inhibitor 98.05% Unkown
HY-150640 Rho-Kinase-IN-2 Inhibitor 98.80% Unkown
HY-149266 THK01 Inhibitor 99.80% Unkown
HY-110339 RKI-1447 dihydrochloride Inhibitor 99.94% Unkown
HY-109191A Sovesudil hydrochloride Inhibitor 99.45% Unkown
HY-18713A CRT0066854 hydrochloride Inhibitor 96.77% Unkown
HY-100270 Rho-Kinase-IN-1 Inhibitor 99.91% Unkown
HY-125221 DJ4 Inhibitor 99.25% Unkown
HY-122011 PF-4950834 Inhibitor 99.60% Unkown
HY-14227 LIMK-IN-1 Inhibitor 99.33% Unkown
HY-15720B Glycyl H-1152 hydrochloride Inhibitor 99.9% Unkown
HY-126275 HSD1590 Inhibitor 99.00% Unkown
HY-U00351 ROCK-IN-1 Inhibitor 99.04% Unkown
HY-178821 ROCK2-IN-12 Inhibitor 98.02% Unkown
HY-107209 RKI-1313 Inhibitor 98.2% Unkown
HY-172177 ROCK/HDAC-IN-2 Inhibitor / Unkown
HY-181582 LASSBio-2382 Inhibitor / Unkown
HY-175843 ROCK2-IN-10 Inhibitor / Unkown
HY-164809 Desisopropyle-belumosudil Inhibitor / Unkown
HY-145294 ROCK2-IN-5 Inhibitor / Unkown
HY-13300A SR-3677 dihydrochloride Inhibitor / Unkown
HY-179498 ROCK2-IN-13 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-184149 ROCK2-IN-17 Inhibitor / Unkown
HY-185667 ROCK2-IN-15 Inhibitor / Unkown
HY-178013 ROCK2-IN-11 Inhibitor / Unkown
HY-153564 ROCK-IN-6 Inhibitor / Unkown
HY-162798 ROCK2-IN-9 Inhibitor / Unkown
HY-103045A CMPD101 hydrochloride Inhibitor / Unkown
HY-149700 ROCK2-IN-7 / Unkown
HY-181576 ROCK2-IN-14 Inhibitor / Unkown
HY-181583 LASSBio-2389 Inhibitor / Unkown
HY-116233 ROCK-IN-13 Inhibitor / Unkown
HY-123939 JAK1/3-IN-1 Inhibitor / Unkown
HY-12659B LX7101 monohydrochloride Inhibitor / Unkown
HY-N15301 Nocarnickelamide B Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rock2 NCBI NCBI:9475