ROCK2 - Rho associated coiled-coil containing protein kinase 2 Gene

Also Known as ROCK-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9475

About ROCK2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:11,179,759-11,345,437 (from NCBI)

This gene has 12 transcripts (splice variants), 309 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 15.2), colon (RPKM 13.4) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-Fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

ROCK2 Products (6)

mRNA	Protein	Name
XM_011510417.3	XP_011508719.1	rho-associated protein kinase 2 isoform X3
XM_017005379.3	XP_016860868.1	rho-associated protein kinase 2 isoform X3
XM_017005378.3	XP_016860867.1	rho-associated protein kinase 2 isoform X2
XM_005246190.4	XP_005246247.1	rho-associated protein kinase 2 isoform X1
NM_004850.5	NP_004841.2	rho-associated protein kinase 2 isoform 1
NM_001321643.2	NP_001308572.1	rho-associated protein kinase 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables Rho-dependent protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	24065547	GOA
enables endopeptidase activator activity	IMP IMP: Inferred from mutant phenotype	24305806	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	24305806	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17015463	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	16574662	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	24305806	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in cellular response to testosterone stimulus	IMP IMP: Inferred from mutant phenotype	24065547	GOA
involved in centrosome duplication	IMP IMP: Inferred from mutant phenotype	17015463	GOA
involved in cortical actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in cortical actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in modulation by host of viral process	IMP IMP: Inferred from mutant phenotype	19376974	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	19181962	GOA
involved in negative regulation of bicellular tight junction assembly	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in negative regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	29353861	GOA
involved in negative regulation of protein localization to lysosome	IMP IMP: Inferred from mutant phenotype	24305806	GOA
involved in positive regulation of amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	24305806	GOA
involved in positive regulation of amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	24305806	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20232393	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24065547	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24065547	GOA
involved in positive regulation of protein localization to early endosome	IMP IMP: Inferred from mutant phenotype	24305806	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24065547	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	20232393	GOA
involved in protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	18559669	GOA
involved in regulation of establishment of endothelial barrier	IGI IGI: Inferred from genetic interaction	25816133	GOA
involved in regulation of establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	25816133	GOA
involved in regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	19997641	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in centrosome	IDA IDA: Inferred from direct assay	17015463	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ROCK2 Protein Structure

Pkinase

HR1

Rho_Binding

0
300
600
900
1200
1388 a.a.

Protein Preferred Names	Protein Names
rho-associated protein kinase 2	p164 ROCK-2 rho-associated, coiled-coil-containing protein kinase II

ROCK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ROCK2	O75116	STAT3	Homo sapiens	P40763	Anti Bait CoIP	30413785
Intra	ROCK2	O75116	STAT3	Homo sapiens	P40763	CH-IP	30413785
Intra	ROCK2	O75116	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	ROCK2	O75116	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	ROCK2	O75116	APP	Homo sapiens	P05067	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

ROCK2 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81922	ROCK2 Antibody (YA1667)	WB, ICC/IF	Human, Rat
HY-P81922A	ROCK2 Antibody (YA1667)(PBS only)	WB, ICC/IF	Human, Rat

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ureteral Obstruction
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (11)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-10583	Y-27632 dihydrochloride	Inhibitor	99.98%	Unkown
HY-10341	Fasudil Hydrochloride	Inhibitor	99.97%	Yes
HY-15307	Belumosudil	Inhibitor	99.83%	Yes
HY-10341A	Fasudil	Inhibitor	99.98%	Yes
HY-15685	Ripasudil	Inhibitor	99.95%	Unkown
HY-15307A	Belumosudil mesylate	Inhibitor	99.89%	Yes
HY-13911A	Hydroxyfasudil hydrochloride	Inhibitor	98.88%	Unkown
HY-13911	Hydroxyfasudil	Inhibitor	98.78%	Unkown
HY-10341C	Fasudil dihydrochloride	Inhibitor	99.98%	Yes
HY-10341B	Fasudil hydrochloride semihydrate	Inhibitor	/	Unkown
HY-15685A	Ripasudil free base	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-109191	Sovesudil	Inhibitor	99.91%	Phase 3
HY-109191A	Sovesudil hydrochloride	Inhibitor	99.45%	Phase 3
HY-15720	H-1152	Inhibitor	99.00%	Phase 2
HY-15687A	SAR407899	Inhibitor	99.67%	Phase 2
HY-12659	LX7101	Inhibitor	99.54%	Phase 2
HY-15687	SAR407899 hydrochloride	Inhibitor	99.14%	Phase 2
HY-16758	Verosudil	Inhibitor	98.22%	Phase 2
HY-16758A	Verosudil hydrochloride	Inhibitor	/	Phase 2
HY-16071	AT13148	Inhibitor	99.20%	Phase 1

Pre-clinical Phase

Bioactive Molecules (51)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-10071	Y-27632	Inhibitor	99.91%	Unkown
HY-15392	Chroman 1	Inhibitor	98.97%	Unkown
HY-103045	CMPD101	Inhibitor	98.96%	Unkown
HY-15556	GSK269962A	Inhibitor	99.75%	Unkown
HY-15720A	H-1152 dihydrochloride	Inhibitor	99.47%	Unkown
HY-119937	ROCK inhibitor-2	Inhibitor	99.92%	Unkown
HY-15755	RKI-1447	Inhibitor	98.02%	Unkown
HY-13300	SR-3677	Inhibitor	99.23%	Unkown
HY-18713	CRT0066854	Inhibitor	99.54%	Unkown
HY-10319	BAY-549	Inhibitor	99.46%	Unkown
HY-108518	SB-772077B dihydrochloride	Inhibitor	99.33%	Unkown
HY-15392A	Chroman 1 dihydrochloride	Inhibitor	98.13%	Unkown
HY-12437	BDP5290	Inhibitor	98.90%	Unkown
HY-15556A	GSK269962A hydrochloride	Inhibitor	99.73%	Unkown
HY-167832	PT109	Inhibitor	99.20%	Unkown
HY-162596	NRL-1049	Inhibitor	99.96%	Unkown
HY-103620	ROCK2-IN-2	Inhibitor	98.05%	Unkown
HY-150640	Rho-Kinase-IN-2	Inhibitor	98.80%	Unkown
HY-149266	THK01	Inhibitor	99.80%	Unkown
HY-110339	RKI-1447 dihydrochloride	Inhibitor	99.94%	Unkown
HY-18713A	CRT0066854 hydrochloride	Inhibitor	96.77%	Unkown
HY-100270	Rho-Kinase-IN-1	Inhibitor	99.91%	Unkown
HY-125221	DJ4	Inhibitor	99.25%	Unkown
HY-122011	PF-4950834	Inhibitor	99.60%	Unkown
HY-14227	LIMK-IN-1	Inhibitor	99.33%	Unkown
HY-15720B	Glycyl H-1152 hydrochloride	Inhibitor	99.9%	Unkown
HY-126275	HSD1590	Inhibitor	99.00%	Unkown
HY-U00351	ROCK-IN-1	Inhibitor	98.17%	Unkown
HY-178821	ROCK2-IN-12	Inhibitor	98.02%	Unkown
HY-107209	RKI-1313	Inhibitor	98.2%	Unkown
HY-172177	ROCK/HDAC-IN-2	Inhibitor	/	Unkown
HY-181582	LASSBio-2382	Inhibitor	/	Unkown
HY-175843	ROCK2-IN-10	Inhibitor	/	Unkown
HY-164809	Desisopropyle-belumosudil	Inhibitor	/	Unkown
HY-145294	ROCK2-IN-5	Inhibitor	/	Unkown
HY-13300A	SR-3677 dihydrochloride	Inhibitor	/	Unkown
HY-179498	ROCK2-IN-13	Inhibitor	/	Unkown
HY-168650	ROCK/HDAC-IN-1	Inhibitor	/	Unkown
HY-184149	ROCK2-IN-17	Inhibitor	/	Unkown
HY-185667	ROCK2-IN-15	Inhibitor	/	Unkown
HY-178013	ROCK2-IN-11	Inhibitor	/	Unkown
HY-153564	ROCK-IN-6	Inhibitor	/	Unkown
HY-162798	ROCK2-IN-9	Inhibitor	/	Unkown
HY-103045A	CMPD101 hydrochloride	Inhibitor	/	Unkown
HY-149700	ROCK2-IN-7		/	Unkown
HY-181576	ROCK2-IN-14	Inhibitor	/	Unkown
HY-181583	LASSBio-2389	Inhibitor	/	Unkown
HY-116233	ROCK-IN-13	Inhibitor	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown
HY-12659B	LX7101 monohydrochloride	Inhibitor	/	Unkown
HY-N15301	Nocarnickelamide B	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ROCK2	VGNC	VGNC:34082
Mus musculus	ROCK2	MGD	MGI:107926
Felis catus	ROCK2	VGNC	VGNC:64715
Rattus norvegicus	ROCK2	RGD	RGD:3590
Macaca mulatta	ROCK2	VGNC	VGNC:76714
Canis familiaris	ROCK2	VGNC	VGNC:49640
Others	ROCK2	NCBI