Igf1r - insulin-like growth factor 1 receptor Gene

Rattus norvegicus

Also known as Igfr1; JTK13; IGFIRC; IGF-1 receptor

Gene ID: 25718 | Gene type: protein coding

About Igf1r

Primary_assembly 1: 121,550,743-121,831,777 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 276 orthologues, 54 paralogues and is associated with 88 phenotypes. Biased expression in Adrenal (RPKM 154.5), Kidney (RPKM 119.) and 9 other tissues.

Summary

Enables G-protein alpha-subunit binding activity; Insulin Receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney Cancer (multiple); liver disease (multiple); and nervous system Cancer (multiple). Orthologous to human IGF1R (Insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf1r Products(2)

mRNA	Protein	Name
NM_001414181.1	NP_001401110.1	insulin-like growth factor 1 receptor isoform 1 precursor
NM_052807.3	NP_434694.1	insulin-like growth factor 1 receptor isoform 2 precursor

Igf1r Protein Structure

Recep_L_domain

Furin-like

Recep_L_domain

FN3

PTKc_InsR_like

0
300
600
900
1200
1372 a.a.

Protein Preferred Names

Protein Names

insulin-like growth factor 1 receptor

IGF-I receptor	insulin-like growth factor I receptor
type-I IGF receptor

Recombinant Igf1r Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78724	IGF-I R Protein, Rat (HEK293, His)	P24062 (E31-H936)	≥95%

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15656	Ceritinib	Inhibitor	99.98%	Yes
HY-15656A	Ceritinib dihydrochloride	Inhibitor	99.57%	Yes
HY-B0025	Voglibose	Inhibitor	≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15494	Picropodophyllin		99.90%	Phase 2
HY-10200	BMS-754807	Inhibitor	99.41%	Phase 2
HY-15749	XL228	Inhibitor	99.29%	Phase 1
HY-13326	ASP3026		99.73%	Phase 1
HY-B0794B	AZ7550 Mesylate	Inhibitor	99.24%	Phase 1
HY-B0794A	AZ7550 hydrochloride	Inhibitor	98.66%	Phase 1

Inhibitory Antibodies (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99165	Teprotumumab	Inhibitor	99.45%	Phase 4
HY-P99294	Ganitumab	Inhibitor	95.00%	Phase 3
HY-P99197	Figitumumab	Inhibitor	96.89%	Phase 3
HY-P99284	Dalotuzumab		97.43%	Phase 2
HY-P99218	Robatumumab	Inhibitor	99.90%	Phase 2
HY-P99712	Lonigutamab	Inhibitor	95.00%	Phase 2
HY-P99672	Istiratumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116624	MAZ51		99.96%	Unkown
HY-10262	BMS-536924		99.83%	Unkown
HY-50866	NVP-AEW541		99.92%	Unkown
HY-15609	AZD-3463		99.58%	Unkown
HY-10524	GSK1904529A		99.66%	Unkown
HY-10252	NVP-ADW742		99.54%	Unkown
HY-N0908	Ginsenoside Rg5		99.86%	Unkown
HY-13203	NVP-TAE 226		99.92%	Unkown
HY-10253	AG1024		99.82%	Unkown
HY-18785	Indirubin Derivative E804		99.79%	Unkown
HY-135680	I-OMe-Tyrphostin AG 538	Inhibitor	99.34%	Unkown
HY-100349	SU4312		99.76%	Unkown
HY-145110	IGF-1R inhibitor-2	Inhibitor	98.36%	Unkown
HY-B0794	AZ7550	Inhibitor	/	Unkown
HY-50866B	NVP-AEW541 dihydrochloride		/	Unkown
HY-108230	ALK-IN-12	Inhibitor	/	Unkown
HY-15494S1	Picropodophyllin-d6		/	Unkown
HY-B0794S	AZ7550-d5	Inhibitor	/	Unkown
HY-RS06615	IGF1R Human Pre-designed siRNA Set A		/	Unkown
HY-RS06616	Igf1r Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS06617	Igf1r Rat Pre-designed siRNA Set A		/	Unkown
HY-N6611	Chimaphilin	Inhibitor	/	Unkown
HY-125102	AZ12253801	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990084	Veligrotug	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igf1r	NCBI	NCBI:3480
Macaca fascicularis	Igf1r	NCBI	NCBI:102130142
Mus musculus	Igf1r	NCBI	NCBI:16001

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