Irak4 - interleukin-1 receptor-associated kinase 4 Gene

Also Known as IRAK-4; NY-REN-64; 8430405M07Rik; 9330209D03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 266632

About Irak4

Chromosome 15: 94,441,524-94,479,696 forward strand.GRCm39:CM001008.3

This gene has 3 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 19 phenotypes. Ubiquitous expression in large intestine adult (RPKM 7.), colon adult (RPKM 5.3) and 25 other tissues.

Summary

Enables interleukin-1 receptor binding activity. Acts upstream of or within cytokine-mediated signaling pathway. Predicted to be located in extracellular space. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in central nervous system; dorsal aorta; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Irak4 Products (1)

mRNA Protein Name
NM_029926.5 NP_084202.2 interleukin-1 receptor-associated kinase 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables interleukin-1 receptor binding IPI
IPI: Inferred from physical interaction
15292196 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16306937 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cytokine production IDA
IDA: Inferred from direct assay
15292196 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
15292196 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Irak4 Protein Structure

Death_IRAK4

Death_IRAK4: cd08793 (8 - 107)

STKc_IRAK4

STKc_IRAK4: cd14158 (169 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 459 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-19836 Zimlovisertib Inhibitor 99.94% Phase 2
HY-135317 Emavusertib Inhibitor 99.97% Phase 2
HY-139374 Zabedosertib Inhibitor 98.22% Phase 2
HY-160487 KME-2780 Inhibitor 98.94% Phase 2
HY-109585 IRAK4-IN-7 Inhibitor 99.36% Phase 2
HY-153368 Zomiradomide Degrader 98.04% Phase 1

Pre-clinical Phase

Bioactive Molecules (85)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145483 KT-474 Inhibitor 99.77% Unkown
HY-18992 AS2444697 Inhibitor 99.54% Unkown
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-153188 JNJ-1013 Degrader 99.97% Unkown
HY-111101 AZ1495 Inhibitor 98.07% Unkown
HY-114181 IRAK4-IN-4 Inhibitor 99.55% Unkown
HY-129966 PROTAC IRAK4 degrader-1 Degrader 99.77% Unkown
HY-148290 KTX-951 Degrader 99.60% Unkown
HY-162359 BIO-7488 Inhibitor 99.44% Unkown
HY-134911 HS-243 Inhibitor 99.95% Unkown
HY-159953 IRAK1/4/pan-FLT3 Kinase-IN-1 Inhibitor 99.25% Unkown
HY-135382A PROTAC IRAK4 degrader-3 Degrader 98.24% Unkown
HY-150735 IRAK4-IN-20 Inhibitor 97.04% Unkown
HY-153673 PROTAC IRAK4 degrader-8 Degrader 99.70% Unkown
HY-179094 PSP-0119 Degrader 98.65% Unkown
HY-175022 PROTAC IRAK4 degrader-13 Degrader 99.58% Unkown
HY-175764 FIP22 Degrader 98.53% Unkown
HY-146112 IRAK4-IN-14 Inhibitor 99.01% Unkown
HY-153224 GLPG2534 Inhibitor 98.73% Unkown
HY-77048 IRAK-4 protein kinase inhibitor 2 Inhibitor 98.07% Unkown
HY-174455A APH02174 hemiformic Degrader / Unkown
HY-123854 PF-06426779 Inhibitor 99.89% Unkown
HY-13276 IRAK inhibitor 2 Inhibitor 99.19% Unkown
HY-174455 APH02174 Degrader 99.19% Unkown
HY-131903 HS271 Inhibitor 99.92% Unkown
HY-159953A IRAK1/4/pan-FLT3 Kinase-IN-1 hydrochloride Inhibitor 98.46% Unkown
HY-177515 IRAK4 modulator-2 Inhibitor 99.86% Unkown
HY-129967 PROTAC IRAK4 ligand-1 Ligand 99.49% Unkown
HY-13278 IRAK inhibitor 4 Inhibitor 99.77% Unkown
HY-179095 UR241-2 Inhibitor 99.68% Unkown
HY-148238 GNE-2256 Inhibitor 99.14% Unkown
HY-13278A IRAK inhibitor 4 (trans) Inhibitor 99.02% Unkown
HY-135317B Emavusertib hydrochloride Inhibitor / Unkown
HY-143231 IRAK4-IN-8 Inhibitor / Unkown
HY-150594 IRAK4-IN-17 Inhibitor / Unkown
HY-48932 IRAK4 ligand-12 Ligand / Unkown
HY-146111 IRAK4-IN-13 Inhibitor / Unkown
HY-162538 LC-MI-3 Degrader / Unkown
HY-148275 KTX-955 Inhibitor / Unkown
HY-178012 GLPG4471 Inhibitor / Unkown
HY-172372 IRAK4-IN-30 Inhibitor / Unkown
HY-148277 KTX-612 / Unkown
HY-158760 PROTAC IRAK4 degrader-11 Degrader / Unkown
HY-148276 KTX-497 / Unkown
HY-150732 IRAK4-IN-18 Inhibitor / Unkown
HY-W900240 BMS-978299 Inhibitor / Unkown
HY-139318 IRAK4 ligand-16 Ligand / Unkown
HY-123956 HG-12-6 Inhibitor / Unkown
HY-161620 DW18134 Inhibitor / Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-168311 PROTAC IRAK4 ligand-5 / Unkown
HY-155574 IRAK4-IN-27 Inhibitor / Unkown
HY-168611 IRAK4 ligand-18 Degrader / Unkown
HY-139315 PROTAC IRAK4 degrader-4 Degrader / Unkown
HY-149345 IRAK4-IN-24 Inhibitor / Unkown
HY-183799 GSI526 Degrader / Unkown
HY-183800 JH-l-25-NH2 Ligand / Unkown
HY-174470 IRAK4 ligand-14 Ligand / Unkown
HY-139316 PROTAC IRAK4 degrader-5 Inhibitor / Unkown
HY-139317 PROTAC IRAK4 degrader-6 Degrader / Unkown
HY-172591 IRAK4 ligand-13 Ligand / Unkown
HY-162641 AF-45 Inhibitor / Unkown
HY-143486 IRAK4-IN-10 Inhibitor / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-135382 PROTAC IRAK4 degrader-2 Inhibitor / Unkown
HY-143485 IRAK4-IN-9 Inhibitor / Unkown
HY-124995 BMS-986126 Inhibitor / Unkown
HY-184915 APH003 Degrader / Unkown
HY-150733 IRAK4-IN-19 Inhibitor / Unkown
HY-168586 PROTAC IRAK4 degrader-12 Degrader / Unkown
HY-145484 PROTAC IRAK4 ligand-3 / Unkown
HY-184916 IRAK4 ligand-17 Degrader / Unkown
HY-146072 IRAK4-IN-11 Inhibitor / Unkown
HY-146073 IRAK4-IN-12 Inhibitor / Unkown
HY-150593 IRAK4-IN-16 Inhibitor / Unkown
HY-142662 PROTAC IRAK3 degrader-1 Degrader / Unkown
HY-160654 IRAK4 modulator-1 Modulator 99.11% Unkown
HY-181708 PROTAC IRAK4 degrader-14 Degrader / Unkown
HY-146113 IRAK4-IN-15 Inhibitor / Unkown
HY-168982 Lomonitinib Inhibitor / Unkown
HY-158374 BIO-8169 Inhibitor / Unkown
HY-176197 IRAK4-IN-31 Inhibitor / Unkown
HY-187692 IRAK4-IN-35 Inhibitor / Unkown
HY-180908 IRAK4-IN-34 Inhibitor / Unkown
HY-174843 IRAK4-IN-32 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irak4 NCBI NCBI:51135