Sos1 - SOS Ras/Rac guanine nucleotide exchange factor 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 313845

Summary

Enables SH3 domain binding activity. Involved in Ras protein signal transduction; neurotrophin Trk Receptor signaling pathway; and positive regulation of signal transduction. Located in neuronal cell body; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sos1 Products (1)

mRNA Protein Name
NM_001100716.1 NP_001094186.1 son of sevenless homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
10913276 RGD
enables epidermal growth factor receptor binding IPI
IPI: Inferred from physical interaction
26442853 RGD
Biological Process GO Annotation Evidence References Source
involved in Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
15728722 RGD
involved in neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15728722 RGD
involved in positive regulation of epidermal growth factor receptor signaling pathway IEP
IEP: Inferred from expression pattern
8577724 RGD
involved in positive regulation of small GTPase mediated signal transduction IMP
IMP: Inferred from mutant phenotype
20219970 RGD
involved in response to ischemia IDA
IDA: Inferred from direct assay
26442853 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10517950 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15728722 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
10517950 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

son of sevenless homolog 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-159127 HRS-4642 98.38% Phase 2
HY-145926 MRTX0902 Inhibitor 99.67% Phase 2
HY-134813 MRTX1133 Inhibitor 99.97% Phase 1

Pre-clinical Phase

Bioactive Molecules (92)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125817 BI-3406 Inhibitor 99.95% Unkown
HY-114398 BAY-293 Inhibitor 98.97% Unkown
HY-134885 RMC-0331 Inhibitor 98.96% Unkown
HY-111671 VUBI1 98.21% Unkown
HY-161233A BTX-6654 formate 98.85% Unkown
HY-153606 VUBI1 analogue-1 98.94% Unkown
HY-P2265A SAH-SOS1A TFA Inhibitor 96.55% Unkown
HY-W056267 3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde 98.0% Unkown
HY-151517 SOS1-IN-14 Inhibitor 99.60% Unkown
HY-161235 BTX-7312 98.35% Unkown
HY-163939 RGT-018 Inhibitor 99.77% Unkown
HY-144962 SOS1-IN-11 Inhibitor 98.22% Unkown
HY-145737A PROTAC SOS1 degrader-1 TFA 98.38% Unkown
HY-W115490 4-Chloro-3-(2,4-dioxo-1,3-diazinan-1-yl)benzoic acid 98.28% Unkown
HY-151881 SOS1-IN-15 Inhibitor 98.04% Unkown
HY-134813A MRTX1133 formic Inhibitor 98.23% Unkown
HY-101796 NSC-70220 Inhibitor 99.42% Unkown
HY-161233 BTX-6654 / Unkown
HY-114398A (S)-BAY-293 97.8% Unkown
HY-144657A (4S)-PROTAC SOS1 degrader-1 diTFA Inhibitor 98.09% Unkown
HY-148278 BI-0474 Inhibitor 99.83% Unkown
HY-158310 SOS1/EGFR-IN-1 Inhibitor 99.54% Unkown
HY-RS13576 SOS1 Human Pre-designed siRNA Set A / Unkown
HY-144212 SOS1-IN-8 Inhibitor / Unkown
HY-122685 UC-773587 Inhibitor / Unkown
HY-124514 UC-857993 Inhibitor / Unkown
HY-124755 RAS activator compound 1 Activator 98.90% Unkown
HY-132129 SOS1-IN-2 Inhibitor / Unkown
HY-144207 SOS1-IN-9 Inhibitor / Unkown
HY-144210 SOS1-IN-6 Inhibitor / Unkown
HY-144211 SOS1-IN-7 Inhibitor / Unkown
HY-144213 SOS1-IN-10 Inhibitor / Unkown
HY-144657 (4S)-PROTAC SOS1 degrader-1 / Unkown
HY-144965 SOS1-IN-12 Inhibitor / Unkown
HY-144967 SOS1-IN-13 Inhibitor / Unkown
HY-145046 SOS1-IN-3 Inhibitor / Unkown
HY-145047 SOS1-IN-4 Inhibitor / Unkown
HY-145048 SOS1-IN-5 Inhibitor / Unkown
HY-145737 PROTAC SOS1 degrader-1 / Unkown
HY-148261 KRAS G12C inhibitor 56 Inhibitor / Unkown
HY-151968 KRAS G12C inhibitor 57 Inhibitor / Unkown
HY-152145 PROTAC SOS1 degrader-3 / Unkown
HY-153674 PROTAC SOS1 degrader-4 / Unkown
HY-153940 SOS1/KRAS-IN-1 Inhibitor / Unkown
HY-153989 SOS1-IN-16 Inhibitor / Unkown
HY-161173 PROTAC SOS1 degrader-5 / Unkown
HY-161236 KRAS ligand 4 Inhibitor / Unkown
HY-161450 LHF418 Inhibitor / Unkown
HY-161452 SOS1 Ligand intermediate-3 Inhibitor / Unkown
HY-161634 PROTAC SOS1 degrader-8 / Unkown
HY-161635 SOS1 Ligand intermediate-4 Inhibitor / Unkown
HY-161636 PROTAC SOS1 degrader-9 / Unkown
HY-161637 E3 ligase Ligand 25 / Unkown
HY-161639 E3 ligase Ligand 26 / Unkown
HY-161654 PROTAC SOS1 degrader-10 / Unkown
HY-161714 HH0043 Inhibitor / Unkown
HY-162281 PROTAC SOS1 degrader-6 / Unkown
HY-163582 PROTAC SOS1 degrader-7 / Unkown
HY-167768 SOS1 activator 2 / Unkown
HY-168514 SOS1/EGFR-IN-2 Inhibitor / Unkown
HY-168637 SIAIS562055 / Unkown
HY-168638 PROTAC SOS1 ligand 1 Inhibitor / Unkown
HY-168716 SOS1-IN-17 Inhibitor / Unkown
HY-169371 SOS1 Ligand intermediate-7 Inhibitor / Unkown
HY-172221 SOS1-IN-18 Inhibitor / Unkown
HY-173047 KRASG12C IN-15 Inhibitor / Unkown
HY-173341 SOF-436 Inhibitor / Unkown
HY-175244 SOS1-IN-20 Inhibitor / Unkown
HY-175326 SOS1-IN-21 Inhibitor / Unkown
HY-175560 SOS1-IN-22 Inhibitor / Unkown
HY-175575 SOS1 ligand-2 Ligand / Unkown
HY-175891 POI ligand-5 / Unkown
HY-176170 SOS1-IN-19 Inhibitor / Unkown
HY-176789 VUBI1-octanoic acid Inhibitor / Unkown
HY-178044 SOS1-IN-24 Inhibitor / Unkown
HY-179414 KRAS G12D-IN-34 Inhibitor / Unkown
HY-179443 SOS1-IN-25 Inhibitor / Unkown
HY-181807 SOS1/KRAS-IN-2 / Unkown
HY-182411 KRAS-IN-56 Inhibitor / Unkown
HY-183365 SL43 Inhibitor / Unkown
HY-19539 NSC-658497 Inhibitor / Unkown
HY-P2265 SAH-SOS1A Inhibitor / Unkown
HY-112078B (S,S,S)-AHPC-Me / Unkown
HY-161638 E3 Ligase Ligand-linker Conjugate 108 / Unkown
HY-161640 E3 Ligase Ligand-linker Conjugate 109 / Unkown
HY-161655 SOS1 Ligand intermediate-5 Inhibitor / Unkown
HY-161656 PIP-C-3-Azaspiro[5.5]undecane-boc / Unkown
HY-161657 2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP / Unkown
HY-163583 SOS1 Ligand intermediate-6 Inhibitor / Unkown
HY-RS16568 Sos1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS23001 Sos1 Rat Pre-designed siRNA Set A / Unkown
HY-RS26460 Sos2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sos1 NCBI NCBI:6654