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Cat. No.: HY-146105

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Anticancer agent 65

Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC₅₀ of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells.

For research use only. We do not sell to patients.

CAS No.: 2407861-48-5
Formula: C₃₆H₆₃NO₅
Molecular Weight:589.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Anticancer agent 65 Chemical Structure

CAS No.: 2407861-48-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

MMP

Bcl-2

Bax

All MMP Isoforms :

All Bcl-2 Family Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.07 μM Compound: 4c	Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
MCF7	IC₅₀	1.27 μM Compound: 4c	Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
MGC-803	IC₅₀	6.51 μM Compound: 4c	Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
PC-3	IC₅₀	5.44 μM Compound: 4c	Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
SGC-7901	IC₅₀	7.11 μM Compound: 4c	Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]

In Vitro

Anticancer agent 65 (compound 4c) increases the expression of Bax and decrease that of Bcl-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2407861-48-5
Molecular Weight 589.89
Formula C₃₆H₆₃NO₅
SMILES

C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)OC(C5CCNCC5)=O)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@](C)(O)CCCC(C)(O)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ma L, et al. Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives. Eur J Med Chem. 2020 Feb 1;187:111964. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Anticancer agent 65

All MMP Isoforms

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Anticancer agent 65 Related Classifications

HY-146105 Related Classifications