CASR - calcium sensing receptor Gene

Also Known as CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; hCasR; GPRC2A; HYPOC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 846

About CASR

Cytogenetic location: 3q13.33-q21.1 Genomic coordinates (GRCh38): 3:122,183,668-122,291,629 (from NCBI)

This gene has 6 transcripts (splice variants), 203 orthologues, 4 paralogues and is associated with 8 phenotypes. Biased expression in kidney (RPKM 8.6), gall bladder (RPKM 2.1) and 2 other tissues.

Summary

The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]

CASR Products (6)

mRNA	Protein	Name
XM_047449065.1	XP_047305021.1	extracellular calcium-sensing receptor isoform X2
XM_017007325.2	XP_016862814.1	extracellular calcium-sensing receptor isoform X1
NM_000388.4	NP_000379.3	extracellular calcium-sensing receptor isoform 2 precursor
XM_017007324.2	XP_016862813.1	extracellular calcium-sensing receptor isoform X1
NM_001178065.2	NP_001171536.2	extracellular calcium-sensing receptor isoform 1 precursor
XM_006713789.4	XP_006713852.1	extracellular calcium-sensing receptor isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	27434672	GOA
enables amino acid binding	IDA IDA: Inferred from direct assay	27434672	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	27434672	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	34194040	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20361938	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16740594	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	27434672	GOA
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8636323	GOA
involved in calcium ion import	IDA IDA: Inferred from direct assay	20846291	GOA
involved in detection of calcium ion	IDA IDA: Inferred from direct assay	27434672	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	27434672	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	8702647	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASR Protein Structure

ANF_receptor

NCD3G

7tm_3

0
200
400
600
800
1000
1078 a.a.

Protein Preferred Names	Protein Names
extracellular calcium-sensing receptor	parathyroid Ca(2+)-sensing receptor 1 parathyroid cell calcium-sensing receptor 1

CASR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CASR	P41180	TMED2	Homo sapiens	Q15363	Y2H	20361938

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CASR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79408	Calcium-sensing Receptor/CaSR Protein, Human (HEK293, His)	P41180-1 (Y20-K601)	≥ 95%, as determined by reducing SDS-PAGE.

CASR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86831	CaSR Antibody (YA6524)	WB, IHC-P, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypoparathyroidism	Hypoparathyroidism, Idiopathic Parathyroid, Underactivity Of Syndrome With Hypoparathyroidism Deficiency Of Parathyroid Hormone Parathyroid Gland Insufficiency Parathyroid Insufficiency Hypoparathyroidism Due To Impaired Pth - [Parathyroid Hormone] Secretion
Hyperparathyroidism	Hyperparathyroidism And Other Disorders Of Parathyroid Gland Parathyroid Hyperfunction Hpth - [Hyperparathyroidism] Parathyroid Gland Hyperfunction Parathyroid Glandular Hyperfunction
Insulinoma	Islet Cell Adenoma Insulin-Producing Tumor Of Islet Cells Adenoma Islet Cell Islet Cell Tumor Experimental Organism Islet Cell Adenoma Neoplasm
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hypoparathyroidism-Retardation-Dysmorphism Syndrome	Sanjad-Sakati Syndrome Hrd Syndrome HRDS Hypoparathyroidism-Intellectual Disability-Dysmorphism Syndrome Hypoparathyroidism-Short Stature-Intellectual Disability-Seizures Syndrome Richardson-Kirk Syndrome Sss Hypoparathyroidism With Short Stature, Mental Retardation, And Seizures Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation, And Developmental Delay Hypoparathyroidism With Short Stature, Mental Retardation And Seizures Hypoparathyroidism With Short Stature, Intellectual Disability And Seizures Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation And Developmental Delay
Gastrinoma	Gastrin Cell Tumour Gastrin Secreting Tumor Malignant Gastrinoma Gastrinoma, Malignant
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
17-Beta Hydroxysteroid Dehydrogenase Iii Deficiency	17-Ksr Deficiency Neutral 17-Beta-Hydroxysteroid Oxidoreductase Deficiency Pseudohermaphroditism, Male, With Gynecomastia 17-Beta Hydroxysteroid Dehydrogenase 3 Deficiency Testosterone 17-Beta-Dehydrogenase Deficiency 17-Ketosteroid Reductase Deficiency Of Testis 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency 17-Ketoreductase Deficiency 17-Ketosteroidreductase Deficiency 46,Xy Disorder Of Sex Development Due To 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency Male Pseudohermaphroditism With Gynecomastia 17 Alpha Ksr Deficiency 17 Alpha Ketosteroid Reductase Deficiency Of Testis 17 Beta Hydroxysteroid Dehydrogenase Iii Deficiency Male Pseudoherma-Phroditism With Gynecomastia Neutral 17 Beta Hydroxysteroid Oxidoreductase Deficiency Male Pseudohermaphrodism With Gynecomastia MPH 17-Hydroxysteroid Dehydrogenase Deficiency
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Phosphorus Metabolism Disease	Phosphorus Metabolism Disorders Disorder Of Phosphorus Metabolism Phosphorus Disorder Phosphorus Metabolism Disorder
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Chondrocalcinosis	Pseudogout Calcium Pyrophosphate Deposition Disease Familial Chondrocalcinosis Chondrocalcinosis Nos Cppd - [Calcium Pyrophosphate Deposition Disease] Cpdd - [Calcium Pyrophosphate Deposition Disease] Chondrocalcinosis, Due To Pyrophosphate Crystals, Involving Unspecified Site Chondrocalcinosis, Cause Unspecified Chondrocalcinosis Due To Pyrophosphate Crystals Chondrocalcinosis Articularis Calcium Pyrophosphate Arthritis And Periarthritis
Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia	APS1 Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Apeced Pga I Hypoadrenocorticism With Hypoparathyroidism And Superficial Moniliasis Autoimmune Polyendocrinopathy Syndrome , Type I, With Or Without Reversible Metaphyseal Dysplasia Polyglandular Autoimmune Syndrome, Type 1 Autoimmune Polyglandular Syndrome Type 1 Autoimmune Polyendocrine Syndrome Type 1 Autoimmune Polyendocrinopathy Syndrome Type 1 Whitaker Syndrome Aps Type 1 Polyglandular Type I Autoimmune Syndrome Aps I Autoimmune Polyglandular Syndrome, Type I Polyglandular Autoimmune Syndrome, Type I Aps 1 Autoimmune Polyglandular Syndrome Type I Pga 1 Pga-I Polyglandular Autoimmune Syndrome Type 1 Type I Polyglandular Autoimmune Syndrome Aire Deficiency Autoimmune Polyendocrinopathy With Candidiasis And Ectodermal Dystrophy Autoimmune Polyglandular Syndrome, Type 1 Autoimmune Polyendocrinopathy Type 1 Apeced Syndrome Autoimmune Hypoparathyroidism-Chronic Candidiasis-Addison Disease Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Syndrome Ham Syndrome Hypoparathyroidism-Addison Disease-Mucocutaneous Candidiasis Syndrome Medac Syndrome Multiple Endocrine Deficiency-Addison Disease-Candidiasis Syndrome Autoimmune Polyendocrine Syndrome 1, With Or Without Reversible Metaphyseal Dysplasia Aps-1 Autoimmune Polyendocrine Syndrome Type I Autoimmune Polyendocrinopathy Syndrome Type I Autosomal Dominant Autoimmune Polyendocrinopathy Syndrome Type I Polyglandular Autoimmune Syndrome Type I Polyglandular Deficiency Syndrome Persian-Jewish Type Autoimmune Polyendocrinopathy Syndrome, Type I, Autosomal Dominant Polyendocrinopathy Autoimmune, Type 1, With/Without Reversible Metaphyseal Dysplasia
Metal Metabolism Disorder	Metal Metabolism, Inborn Errors Inborn Metal Metabolism Disorder
Hyperparathyroidism, Neonatal Severe	NSHPT Neonatal Severe Primary Hyperparathyroidism Nsph Nhpt Hyperparathyroidism, Neonatal Hyperparathyroidism, Neonatal Severe Primary Neonatal Severe Hyperparathyroidism Hyperparathyroidism, Severe, Neonatal Neonatal Hyperparathyroidism
Parathyroid Adenoma	Adenoma Of Parathyroid Adenoma Of The Parathyroid Gland Parathyroid Gland Adenoma
Hypercalcemia, Infantile, 1	HCINF1 Hypercalcemia, Idiopathic, Of Infancy Hypercalcemia Infantile Idiopathic Hypercalcemia Of Infancy Infantile Hypercalcemia Hypercalcemia, Infantile Hypercalcemia, Infantile, Type 1 Hypercalcemia
Nephrolithiasis	Kidney Stones Stone - Kidney/Ureter Kidney Calculi
Mineral Metabolism Disease	Mineral Metabolism Disorder Disorder Of Mineral Metabolism
Nephrogenic Diabetes Insipidus	Vasopressin-Resistant Diabetes Insipidus Diabetes Insipidus, Nephrogenic Diabetes Insipidus Nephrogenic Congenital Nephrogenic Diabetes Insipidus Adh Resistant Diabetes Insipidus Diabetes Insipidus Nephrogenic X-Linked Diabetes Insipidus Nephrogenic Type 1 Adh-Resistant Diabetes Insipidus Diabetes Insipidus Renalis Ndi Renal Diabetes Insipidus Familial Nephrogenic Diabetes Antidiuretic-Hormone-Resistant Diabetes Insipidus Adiuretin-Resistant Diabetes Insipidus Ndi - [Nephrogenic Diabetes Insipidus] Diabetes Tenuifluus Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus Hereditary Nephrogenic Diabetes Insipidus Familial Nephrogenic Diabetes Insipidus Primary Nephrogenic Diabetes Insipidus
Pancreatitis	Mumps Pancreatitis
Renal Tubular Transport Disease	Renal Tubular Transport, Inborn Errors Inborn Renal Tubular Transport Disorder
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Bartter Disease	Bartter Syndrome Bartter'S Syndrome Aldosteronism With Hyperplasia Of The Adrenal Cortex Hypokalemic Alkalosis With Hypercalciuria Potassium Wasting Juxtaglomerular Hyperplasia With Secondary Aldosteronism Renal Tubular Normotensive Hypokalemic Alkalosis With Hypercalciuria Salt-Losing Tubular Disorder, Henle'S Loop Type Salt-Wasting Tubulopathy, Henle'S Loop Type Bartters Syndrome
Hypocalciuric Hypercalcemia, Familial, Type Iii	HHC3 Familial Hypocalciuric Hypercalcemia 3 Fbh3 Familial Hypocalciuric Hypercalcemia Type 3 Hypercalcemia, Familial Benign, Oklahoma Type Hypocalciuric Hypercalcemia, Type Iii Fhh Type 3 Hypocalciuric Hypercalcemia Type Iii Familial Benign Hypercalcemia, Type Iii Hypercalcemia, Familial Benign, Type Iii Fbhok Familial Benign Hypercalcemia, Oklahoma Variant Familial Benign Hypercalcemia, Type 3 Hypercalcemia, Familial Benign, Type 3 Hypocalciuric Hypercalcemia, Familial, Type 3 Hypocalciuric Hypercalcemia, Familial 3 Familial Benign Hypercalcemia 3 Familial Benign Hypercalcemia Oklahoma Type Familial Benign Hypocalciuric Hypercalcemia 3 Fbhh3 Fhh3
Hypocalcemia, Autosomal Dominant 1	Autosomal Dominant Hypocalcemia Autosomal Dominant Hypocalcemia 1 HYPOC1 Hypocalcemia, Autosomal Dominant Hypercalciuric Hypocalcemia Hypocalcemia, Autosomal Dominant, With Bartter Syndrome Familial Hypocalcemia Hypocalcemia, Familial Hypoc Adh Autosomal Dominant Hypoparathyroidism Familial Hypercalciuric Hypocalcemia Ad Hypocalcemia Autosomal Dominant Hypocalcemia With Bartter Syndrome Hypoparathyroidism - Autosomal Dominant Hypocalcemia
Hypercalciuria, Absorptive, 2	HCA2 Hypercalciuria, Absorptive, Susceptibility To Hypercalciuria, Absorptive Familial Idiopathic Hypercalciuria Hypercalciuria, Familial Idiopathic Hypercalciuria Absorptive 2 Hypercalciuria Familial Idiopathic Hypercalciuria, Absorptive, Type 2 Hypercalciuria
Epilepsy, Idiopathic Generalized	Idiopathic Generalized Epilepsy Generalised Epilepsy Epilepsy, Generalized EIG Ige Epilepsy, Idiopathic Generalized, Susceptibility To, 1 Epilepsy, Idiopathic Generalized 1 Epilepsy, Idiopathic Generalized, Susceptibility To Epilepsy, Idiopathic, Generalized Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Parathyroid Gland Disease	Parathyroid Diseases Disease Of Parathyroid Glands Parathyroid Disease
Familial Isolated Hypoparathyroidism	Fih
Urolithiasis
Secondary Hyperparathyroidism	Hyperparathyroidism Secondary Hyperparathyroidism, Secondary Secondary Hyperparathyroidism Nec
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Epilepsy, Myoclonic Juvenile	Juvenile Myoclonic Epilepsy Janz Syndrome Jme Myoclonic Epilepsy, Juvenile, Susceptibility To, 1 EJM Myoclonic Epilepsy, Juvenile Petit Mal, Impulsive Myoclonic Epilepsy, Juvenile 1 Myoclonic Epilepsy, Juvenile, 1 Adolescent Myoclonic Epilepsy Juvenile Myoclonus Epilepsy Juvenile Myoclonic Epilepsy 1 EJM1 Petit Mal Impulsive Susceptibility To Juvenile Myoclonic Epilepsy 1 Myoclonic Epilepsy Juvenile Epilepsy, Myoclonic, Juvenile Myoclonic Epilepsy Of Janz Jme - [Juvenile Myoclonic Epilepsy]
Renal Osteodystrophy	Renal Rickets Chronic Kidney Disease-Mineral And Bone Disorder
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1
Hyperparathyroidism 2 With Jaw Tumors	Hyperparathyroidism-Jaw Tumor Syndrome Hpt-Jt HRPT2 Familial Primary Hyperparathyroidism With Multiple Ossifying Jaw Fibromas Parathyroid Adenoma With Cystic Changes Hereditary Hyperparathyroidism-Jaw Tumor Syndrome Hyperparathyroidism 2 Hyperparathyroidism, Familial Primary, With Multiple Ossifying Jaw Fibromas Hyperparathyroidism-Jaw Tumor Syndrome, Hereditary Familial Cystic Parathyroid Adenomatosis Hyperparathyroidism-Jaw Tumor Syndrome, Type 2 Parathyroid Adenomatosis, Familial Cystic
Autoimmune Polyendocrine Syndrome Type 1	Whitaker Syndrome Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Autoimmune Polyglandular Syndrome I Polyglandular Type I Autoimmune Syndrome
Basal Ganglia Disease	Basal Ganglia Diseases Basal Ganglia Disorders Abnormality Of The Basal Ganglia
Gitelman Syndrome	Familial Hypokalemia-Hypomagnesemia Hypomagnesemia-Hypokalemia, Primary Renotubular, With Hypocalciuria Potassium And Magnesium Depletion GTLMNS Gitelman'S Syndrome Gs Hypokalemia-Hypomagnesemia, Primary Renotubular, With Hypocalciuria Tubular Hypomagnesemia-Hypokalemia With Hypocalcuria Bartter Syndrome Gitelman Variant Bartter Syndrome Hypocalciuric Variant Primary Renotubular Hypomagnesemia-Hypokalemia With Hypocalciuria
Diabetes Insipidus
Inflammatory Diarrhea
Epilepsy, Idiopathic Generalized 8	Epilepsy, Idiopathic Generalized, Susceptibility To, 8 EIG8 Epilepsy Idiopathic Generalized, Susceptibility To, 8 Epilepsy Idiopathic Generalized 8 Idiopathic Generalized Epilepsy 8 Susceptibility To Idiopathic Generalized Epilepsy 8 Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 8
Hyperphosphatemia
Bartter Syndrome, Type 3	Bartter Disease Type 3 BARTS3 Bartter Syndrome Type 3 Bartter Syndrome, Classic Classic Bartter Syndrome Bartter Syndrome Classic Bartter Syndrome Type Iii Bartter Syndrome 3
Rickets	Vitamin D Deficiency Active Rickets Hypovitaminosis D Nutritional Rickets Vitamin D Deficiency Disease Vitamin-D Deficiency Rickets Vitamin D Vitamin D-Dependent Rickets Avitaminosis D Infantile Osteomalacia Juvenile Osteomalacia
Uremia	Uremia Of Renal Origin
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Parathyroid Carcinoma	Parathyroid Cancer Parathyroid Neoplasms Malignant Tumor Of Parathyroid Gland PRTC Carcinoma Of Parathyroid Gland Malignant Neoplasm Of Parathyroid Gland Parathyroid Gland Adenocarcinoma Parathyroid Gland Cancer Parathyroid Neoplasm Parathyroid Gland Carcinoma Malignant Neoplasm Of The Parathyroid Neoplasm Of Parathyroid Gland Parathyroid Gland Neoplasm Cancer Of The Parathyroid Cancer Of The Parathyroid Gland Malignant Neoplasm Of Parathyroid Malignant Parathyroid Gland Neoplasm Malignant Parathyroid Gland Tumor Malignant Parathyroid Neoplasm Malignant Parathyroid Tumor Malignant Tumor Of Parathyroid Parathyroid Adenocarcinoma Neoplasm Of The Parathyroid Gland Carcinoma, Parathyroid
Hypocalciuric Hypercalcemia, Familial, Type Ii	HHC2 Familial Hypocalciuric Hypercalcemia 2 Fbh2 Familial Hypocalciuric Hypercalcemia Type 2 Hypocalciuric Hypercalcemia, Type Ii Fhh Type 2 Familial Benign Hypercalcemia, Type Ii Hypercalcemia, Familial Benign, Type Ii Hypocalciuric Hypercalcemia Type Ii Familial Benign Hypercalcemia, Type 2 Hypercalcemia, Familial Benign Type 2 Hypocalciuric Hypercalcemia, Familial, Type 2 Hypocalciuric Hypercalcemia, Familial 2 Familial Benign Hypercalcemia Type Ii Hypocalciuric Hypercalcemia-2
Primary Hyperparathyroidism	Familial Primary Hyperparathyroidism Hyperparathyroidism, Primary Hyperparathyroidism Primary Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Benign Hypercalcemia Familial Hyperparathyroidism Parathyroid Enlargement
Pancreatitis, Hereditary	Hereditary Pancreatitis Chronic Pancreatitis Hereditary Chronic Pancreatitis Hp Pancreatitis, Chronic, Susceptibility To PCTT Hpc Pancreatitis, Chronic Pancreatitis, Chronic, Protection Against Autosomal Dominant Hereditary Pancreatitis Familial Pancreatitis Cp Pancreatitis Hereditary
Osteitis Fibrosa	Osteitis Fibrosa Cystica Hyperparathyroid Bone Disease Osteitis Fibrosa Cystica Generalisata Von Recklinghausen'S Bone Disease Osteitis Fibrosa Disseminata
Calciphylaxis	Idiopathic Calciphylaxis
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy, Hypertrophic, Familial Familial Hypertrophic Cardiomyopathy Cardiomyopathy Hypertrophic Obstructive Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Kenny-Caffey Syndrome	Kenny Syndrome
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Basal Ganglia Calcification	Fahr'S Syndrome Fahr'S Disease Fahr Disease
Sialolithiasis	Sialolith Stone Of Salivary Gland Or Duct Salivary Gland Calculi Salivary Gland Stone Calculus Of Salivary Gland Or Duct Calculus Of Salivary Gland Salivary Calculus Salivary Gland Calculus Salivary Stone Salivary Duct Calculi Sialodocholithiasis
Hypoparathyroidism-Deafness-Renal Disease Syndrome	Barakat Syndrome Hypoparathyroidism, Deafness, Renal Disease Syndrome Hdr Syndrome Hypoparathyroidism, Sensorineural Deafness, And Renal Disease
Autoimmune Polyendocrine Syndrome	Autoimmune Polyendocrinopathy Autoimmune Polyglandular Failure Autoimmune Polyglandular Syndrome Polyendocrinopathies, Autoimmune Lloyd'S Syndrome Aps Polyendocrinopathies Autoimmune Polyendocrine Autoimmunity Syndrome Lloyd Syndrome Polyglandular Autoimmune Deficiency Progressive Pluriglandular Insufficiency Pluriglandular Autoimmune Atrophy Pluriglandular Autoimmune Syndrome Thyroid-Adrenocortical Insufficiency Syndrome
Diarrhea 1, Secretory Chloride, Congenital	DIAR1 Chloride Diarrhea, Congenital, Finnish Type Congenital Secretory Chloride Diarrhea 1 Congenital Chloride Diarrhea Finnish Type Congenital Chloride Diarrhea Chloridorrhea, Congenital Congenital Chloride Diarrhoea Finnish Type Congenital Chloridorrhea Congenital Secretory Chloride Diarrhoea 1 Chloridorrhea Congenital Cld Diarrhea 1 Secretory Chloride Congenital Diarrhea, Type 1, Chloride, Secretory, Congenital
Hypokalemia	Potassium Deficiency Potassium Deficiency Disorder Hypopotassemia Potassium Potassium [K] Deficiency Hypokalaemic Syndrome Hypopotassaemia Hypopotassaemia Syndrome Hypokalaemic Potassium Depletion
Bartter Syndrome, Type 2, Antenatal	Bartter Disease Type 2 BARTS2 Hyperprostaglandin E Syndrome 2 Bartter Syndrome, Type 2 Bartter Syndrome Type 2 Hypokalemic Alkalosis With Hypercalciuria Antenatal 2 Hypokalemic Alkalosis With Hypercalciuria 2, Antenatal Bartter Syndrome Type 2 Antenatal Hypokalemic Alkalosis With Hypercalciuria 2 Antenatal Bartter Syndrome Antenatal Type 2 Bartter Syndrome Type Ii Bartter Syndrome 2, Antenatal Abs2 Antenatal Bartter Syndrome 2 Bartter Syndrome 2 Bs2 Hyperprostanglandin E Syndrome 2 Bartter Syndrome, Antenatal , Type 2 Antley-Bixler Syndrome, Autosomal Dominant
Hypocalciuric Hypercalcemia, Familial, Type I	HHC1 Familial Hypocalciuric Hypercalcemia 1 Fhh1 Familial Benign Hypercalcemia 1 Fbh1 Hypocalciuric Hypercalcemia, Type I Fhh Type 1 Hhc Fhh Hypercalcemia, Familial Benign Hypocalciuric Hypercalcemia Type I Familial Hypocalciuric Hypercalcemia Type 1 Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Hypocalciuric Hypercalcemia Type I Familial Benign Hypercalcemia Type 1 Hypercalcemia, Familial Benign Type 1 Hypocalciuric Hypercalcemia, Familial 1 Familial Benign Hypocalciuric Hypercalcemia 1 Fbhh1
Osteomalacia	Adult Rickets
Diabetes Mellitus	Diabetes
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Sensorineural Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Conn'S Syndrome	Cushing Syndrome Hyperaldosteronism Primary Hyperaldosteronism Hypercortisolism Primary Aldosteronism Cushing'S Syndrome Adrenal Gland Hyperfunction Conn Syndrome Hyperadrenalism Ectopic Acth Syndrome Hyperadrenocorticism Cushing Disease Adrenal Cortex Adenoma Corticotroph Pituitary Adenoma Cushing'S Disease Pituitary Corticotroph Micro-Adenoma Pituitary-Dependent Cushing Syndrome Pituitary Acth Hypersecretion Acth Syndrome, Ectopic Acth-Secreting Pituitary Adenoma Adrenal Hyperfunction Resulting From Pituitary Acth Excess Ectopic Adrenocorticotropic Hormone Syndrome Nodular Primary Adrenocortical Dysplasia Pituitary Dependent Cushing Syndrome Pituitary Cushing Syndrome Pituitary-Dependant Cushing Syndrome Pituitary-Dependant Hypercortisolism Pituitary-Dependant Hypercortisolism Disorder Aldosteronism Primary Acth Syndrome Ectopic Adrenal Cushing'S Syndrome Adrenal Cortical Adenoma Cushing Syndrome Nos Cortisol Hypersecretion Corticoadrenal Hypersecretion Cushing Syndrome Secondary To Ectopic Acth-Secretion Ectopic Cushing Syndrome Hypercortisolism Due To Nonpituitary Tumour Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome Idiopathic Aldosteronism Aldosteronism Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia Primary Aldosteronism Due To Adrenal Hyperplasia
Nephrolithiasis, Calcium Oxalate	Kidney Stones Calculus Of Kidney Kidney Calculi Nephrolithiasis Renal Calculi Calcium Oxalate Urolithiasis CAON Urolithiasis, Calcium Oxalate Calcium Oxalate Nephrolithiasis Kidney Stone Nephrolith Renal Calculus Urinary Stones Renal Stone Calculus, Kidney Calculus, Renal Renal Lithiasis Renal Stones Urolithiasis Renal Calculus Or Stone Stone In Kidney Nephritic Calculus Multiple Kidney Calculi Multiple Kidney Calculus Nephrolithiasis Nos Pelvic Nephrolithiasis Pelviolithiasis Pelvis Nephrolithiasis
Multiple Endocrine Neoplasia, Type I	Multiple Endocrine Neoplasia Type 1 MEN1 Wermer Syndrome Multiple Endocrine Neoplasia 1 Multiple Endocrine Neoplasia, Type 1 Men I Endocrine Adenomatosis, Multiple Mea I Men Type I Wermer'S Syndrome Men1 Syndrome Multiple Endocrine Adenomatosis Endocrine Adenomatosis Multiple Men 1 Familial Multiple Endocrine Neoplasia Type I Neoplasia, Endocrine, Multiple, Type 1 Multiple Endocrine Neoplasia
Nephrocalcinosis	Hypercalcemic Nephropathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-70037	Cinacalcet	Agonist	99.93%	Yes
HY-70037A	Cinacalcet hydrochloride	Agonist	99.98%	Yes
HY-P1955A	Etelcalcetide hydrochloride	Activator	99.80%	Unkown
HY-17397	Strontium Ranelate	Activator	99.30%	Unkown
HY-17613	Evocalcet	Activator	99.28%	Unkown
HY-109106A	Upacicalcet sodium	Agonist	99.91%	Unkown
HY-P1955	Etelcalcetide	Activator	/	Unkown
HY-109106	Upacicalcet	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14401	Encaleret	Antagonist	99.88%	Phase 3
HY-10007	NPS-2143	Antagonist	99.94%	Phase 2
HY-10167A	Tecalcet Hydrochloride	Modulator	99.43%	Phase 2
HY-15105	SB-423562	Antagonist	99.62%	Phase 2
HY-14752	Ronacaleret	Antagonist	/	Phase 2
HY-177303	AXT-914	Inhibitor	98.83%	Phase 1

Pre-clinical Phase

Bioactive Molecules (43)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139201A	Poly-D-lysine hydrobromide (MW 70000-150000)	Agonist	99.86%	Unkown
HY-139201	Poly-D-lysine hydrobromide (MW 30000-70000)	Agonist	/	Unkown
HY-112171	γ-L-Glutamyl-L-alanine	Modulator	98.0%	Unkown
HY-12557	γ-Glutamylvaline	Agonist	99.94%	Unkown
HY-10171	NPS-2143 hydrochloride	Antagonist	99.98%	Unkown
HY-103320A	Calhex 231 hydrochloride	Inhibitor	99.81%	Unkown
HY-N0546	Ligustroflavone	Antagonist	99.90%	Unkown
HY-139201B	Poly-D-lysine hydrobromide (MW 84000)	Agonist	/	Unkown
HY-11095	NPS 2390	Inhibitor	99.90%	Unkown
HY-122819	Calindol hydrochloride	Agonist	99.64%	Unkown
HY-121584	Lycoperodine-1	Agonist	99.82%	Unkown
HY-139201D	Poly-D-lysine hydrobromide (MW 4000-15000)		/	Unkown
HY-W843885	H-Glu-Thr-OH	Activator	98.63%	Unkown
HY-P4376A	Gamma-Glu-Abu TFA	Agonist	96.83%	Unkown
HY-103320B	(1R,2R)-Calhex 231 hydrochloride	Control	98.45%	Unkown
HY-117851	AC-265347	Agonist	99.97%	Unkown
HY-112171R	γ-L-Glutamyl-L-alanine (Standard)	Modulator	99.29%	Unkown
HY-139201E	Poly-D-lysine hydrobromide (MW 150000-300000)	Agonist	/	Unkown
HY-50713	Calcium-Sensing receptor antagonist I	Antagonist	98.95%	Unkown
HY-107773	GSK3004774	Agonist	99.09%	Unkown
HY-W017018B	L-Ornithine monohydrochloride,suitable for cell culture	Activator	99.73%	Unkown
HY-139201H	Poly-D-lysine hydrobromide (MW ≥300000)	Activator	/	Unkown
HY-15104	Ronacaleret hydrochloride	Antagonist	99.81%	Unkown
HY-70037AS	Cinacalcet-d3 hydrochloride	Agonist	97.63%	Unkown
HY-P11832	CaSR agonist peptide-1	Agonist	/	Unkown
HY-139201C	Poly-D-lysine hydrobromide (MW 1000-5000)	Activator	/	Unkown
HY-P4376	Gamma-Glu-Abu	Agonist	/	Unkown
HY-14401B	Encaleret sodium	Antagonist	/	Unkown
HY-15106	SB-423557	Antagonist	/	Unkown
HY-W777503	Calindol hydrochloride-13C,D2		/	Unkown
HY-179475	KP-2067	Agonist	/	Unkown
HY-153258	CaSR antagonist-1	Antagonist	/	Unkown
HY-P11668	Gosicalcetide	Agonist	/	Unkown
HY-103320	Calhex 231	Antagonist	/	Unkown
HY-109106B	(Rac)-Upacicalcet		95.0%	Unkown
HY-70037S	Cinacalcet-d3	Agonist	/	Unkown
HY-10167	Tecalcet	Modulator	/	Unkown
HY-17613S	Evocalcet-d4	Activator	/	Unkown
HY-182543	NPS-467	Activator	/	Unkown
HY-171446	TAK-075	Antagonist	/	Unkown
HY-161113	Z8554052021	Activator	/	Unkown
HY-15105A	SB-423562 hydrochloride	Antagonist	/	Unkown
HY-W653978	Cinacalcet-d4 hydrochloride	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CASR	VGNC	VGNC:26788
Rattus norvegicus	CASR	RGD	RGD:2277
Felis catus	CASR	VGNC	VGNC:60388
Canis familiaris	CASR	VGNC	VGNC:38740
Mus musculus	CASR	MGD	MGI:1351351
Macaca mulatta	CASR	VGNC	VGNC:70550
Others	CASR	NCBI