セファクロル
Based on 2 publication(s) in Google Scholar
Cefaclor is a well-absorbed orally active cephalosporin antibiotic. Cefaclor can specifically bind to specific for penicillin-binding protein 3 (PBP3). Cefaclor can be used for the research of depression and kinds of infections caused by bacteria, such as respiratory tract infections, bacterial bronchitis, pharyngitis and skin infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.51%
- CAS 番号: 53994-73-3
- 分子式: C15H14ClN3O4S
- 分子量:367.81
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Cefaclor (Standard)Antibiotic -
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Mycophenolate MofetilIMPDH Inhibitor
MedChemExpress（MCE）の使用を引用している文献 Cefaclor
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生物活性
製品説明
IC50 & Target
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β-lactam |
hOAT1 |
hPepT1-人肽转运蛋白 1 |
hPepT2-人肽转运蛋白 2 |
CD63 |
BDNF |
5-HT Receptor |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
8200 μM
Compound: Cefaclor
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TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing CHO cells
TP_TRANSPORTER: inhibition of Gly-Sar uptake (Gly-Sar: 20 uM) in PEPT1-expressing CHO cells
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[PMID: 10052994] |
体外実験
Cefaclor (0-500 μg/mL, 12-24 h) shows obvious antibacterial activity against 556 Gram-positive and Gram-negative isolates. The MIC values of most strains are lower than 3.1 μg/mL, and the MIC value of Staph. aureus is 1 μg/mL in vitro[4].
Cefaclor (60/500 μM, 30 min) is mainly transported by hPepT2 and hPepT1 in the MDCK stably transduced cell line overexpressing hOAT1、hPepT1 and hPepT2[2].
Cefaclor (0.16 mg/mL, 30 min) can induce allergic reactions by directly activating basophils and mast cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice (male, 5 weeks old)[1]
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Dosage:200 mg/kg/day, once a day for 5 days.
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Administration:p.o.
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Result:Significantly decreased serotonin levels in the hippocampus and BDNF in mice.
Cefaclor-induced gut dysbiosis caused anxiety and depression through the microbiota-gut-blood-brain and the microbiota-gut-vagus nerve-brain pathway.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
化学情報
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CAS 番号 53994-73-3
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性状 Solid
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分子量 367.81
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分子式 C15H14ClN3O4S
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Color Light yellow to yellow
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SMILES
O=C(C(N12)=C(Cl)CS[C@]2([H])[C@H](NC([C@H](N)C3=CC=CC=C3)=O)C1=O)O
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別名
Cefaclor
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
2023 Mar 22;14(1):1594. PMID: 36949052 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996
溶剤 & 溶解度
体外:
DMSO : 18.5 mg/mL (50.30 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 3.85 mg/mL (10.47 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 3.33 mg/mL (9.05 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 40 mg/mL (108.75 mM); Suspended solution; Need ultrasonic
純度とドキュメンテーション
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データシート (278 KB)
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SDS (419 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Joo MK, et al. Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice. Sci Rep. 2023 Sep 19;13(1):15529. [Content Brief]
[2]. Li M, et al. Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Drug Metab Dispos. 2006 Apr;34(4):547-55. [Content Brief]
[3]. Yoo HS, et al. Immunologic evaluation of immediate hypersensitivity to cefaclor. Yonsei Med J. 2014 Nov;55(6):1473-83. [Content Brief]
[4]. Neu HC, et al. Cefaclor: in vitro spectrum of activity and beta-lactamase stability. Antimicrob Agents Chemother. 1978 Apr;13(4):584-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.7188 mL | 13.5940 mL | 27.1880 mL | 67.9699 mL |
| 5 mM | 0.5438 mL | 2.7188 mL | 5.4376 mL | 13.5940 mL | |
| 10 mM | 0.2719 mL | 1.3594 mL | 2.7188 mL | 6.7970 mL | |
| DMSO | 15 mM | 0.1813 mL | 0.9063 mL | 1.8125 mL | 4.5313 mL |
| 20 mM | 0.1359 mL | 0.6797 mL | 1.3594 mL | 3.3985 mL | |
| 25 mM | 0.1088 mL | 0.5438 mL | 1.0875 mL | 2.7188 mL | |
| 30 mM | 0.0906 mL | 0.4531 mL | 0.9063 mL | 2.2657 mL | |
| 40 mM | 0.0680 mL | 0.3398 mL | 0.6797 mL | 1.6992 mL | |
| 50 mM | 0.0544 mL | 0.2719 mL | 0.5438 mL | 1.3594 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cefaclor 関連分類
HY-B0198 関連分類
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