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製品番号: HY-146444

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Anticancer agent 56

Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with agent-likeness properties, possessing anticancer activity against several cancer cell lines (IC₅₀<3 μM). Anticancer agent 56 induces cell cycle arrest at G2/M phase and triggers mitochondrial apoptosis pathway. Anticancer agent 56 acts by accumulation of ROS, up regulation of BAX, down regulation of Bcl-2 and activation of caspases 3, 7, 9.

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CAS 番号: 2241915-59-1
分子式: C₂₀H₁₈ClN₃O₃
分子量:383.83

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Anticancer agent 56 構造式

CAS 番号: 2241915-59-1

容量

価格（税別）

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数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

IC₅₀: 0.64 ± 0.02 μM in Leukemia RPMI-8226, 0.96 ± 0.04 μM in Leukemia SR, 0.84 ± 0.07 μM in Leukemia K-562, 0.69 ± 0.01 μM in Melanoma M14, 0.24 ± 0.01 μM in Breast MCF7, 0.26 ± 0.01 μM in Colon HCT116, 2.95 ± 0.14 μM in Prostate PC3^[1]

Bcl-2 Family アイソフォーム固有の製品をすべて表示 :

Caspase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CCD-18Co	IC₅₀	17.15 μM Compound: 4d	Cytotoxicity against human CCD-18Co cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human CCD-18Co cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
HCT-116	IC₅₀	0.26 μM Compound: 4d	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
K562	IC₅₀	0.84 μM Compound: 4d	Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
K562	IC₅₀	0.84 μM Compound: 14	Antiproliferative activity against human K562 cells Antiproliferative activity against human K562 cells	[PMID: 38889607]
Leukemia cell	IC₅₀	0.96 μM Compound: 14	Cytotoxicity against human Leukemia cancer cells Cytotoxicity against human Leukemia cancer cells	[PMID: 38889607]
M14	IC₅₀	0.69 μM Compound: 4d	Cytotoxicity against human M14 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human M14 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
MCF-10A	IC₅₀	25 μM Compound: 4d	Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
MCF7	IC₅₀	0.24 μM Compound: 4d	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
PC-3	IC₅₀	2.95 μM Compound: 4d	Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
RPMI-8226	IC₅₀	0.64 μM Compound: 4d	Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]
RPMI-8226	IC₅₀	0.64 μM Compound: 14	Antiproliferative activity against human RPMI-8226 cells Antiproliferative activity against human RPMI-8226 cells	[PMID: 38889607]
SR	IC₅₀	0.96 μM Compound: 4d	Cytotoxicity against human SR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human SR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31986406]

化学情報

CAS 番号 2241915-59-1
分子量 383.83
分子式 C₂₀H₁₈ClN₃O₃
SMILES

COC1=C(C=C(C=C1)/C=C/C(C2=C(N(N=N2)C3=CC=C(C=C3)Cl)C)=O)OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ashour HF, et al. 1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226. Eur J Med Chem. 2020;189:112062. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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Anticancer agent 56

Bcl-2 Family アイソフォーム固有の製品をすべて表示

Caspase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Anticancer agent 56 関連分類

HY-146444 関連分類