Anticancer agent 65
Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells.
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- CAS 番号: 2407861-48-5
- 分子式: C36H63NO5
- 分子量:589.89
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
|
MMP |
Bcl-2 |
Bax |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.07 μM
Compound: 4c
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Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
|
[PMID: 31862444] |
| MCF7 | IC50 |
1.27 μM
Compound: 4c
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Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
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[PMID: 31862444] |
| MGC-803 | IC50 |
6.51 μM
Compound: 4c
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Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
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[PMID: 31862444] |
| PC-3 | IC50 |
5.44 μM
Compound: 4c
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Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
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[PMID: 31862444] |
| SGC-7901 | IC50 |
7.11 μM
Compound: 4c
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Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
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[PMID: 31862444] |
Anticancer agent 65 (compound 4c) increases the expression of Bax and decrease that of Bcl-2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2407861-48-5
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分子量 589.89
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分子式 C36H63NO5
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SMILES
C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)OC(C5CCNCC5)=O)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@](C)(O)CCCC(C)(O)C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Anticancer agent 65 関連分類
HY-146105 関連分類
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