Apoptosis inducer 30
Apoptosis inducer 30 (Compound 15a) is an anticancer agent. Apoptosis inducer 30 induces MCF-7 cells apoptosis through mitochondrial pathway. Apoptosis inducer 30 induces intracellular reactive oxygen species levels and decreases mitochondrial membrane potential, and blocks the cell cycle in the G0/G1 phase. Apoptosis inducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and inhibits tumor growth in a mouse model of breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C52H69BrNO4P
- 分子量:882.99
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Caspase アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
IC50 & Target
[1]|
Caspase-9 |
Caspase-7 |
体外実験
Apoptosis inducer 30 inhibits tumor growth, with IC50s of 1.01, 0.91, 0.32, 0.95, 8.09 μM for A549, HepG2, MCF-7, HeLa, MCF-10A cell respectively[1].
Apoptosis inducer 30 (100-500 nM, 48 h) increases Cyt-C levels in the cytoplasm, and activates caspase-9 and caspase-7 in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
分子量 882.99
-
分子式 C52H69BrNO4P
-
SMILES
CC(C)[C@H](C)/C=C/[C@@H](C)[C@H]1CCC2[C@@]34C=C[C@@]5(OO4)C[C@@H](OC(NCCCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=O)CC[C@]5(C)C3CC[C@@]21C.[Br-]
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptosis inducer 30 関連分類
HY-168589 関連分類
Powered by Bioz