iRucaparib-TP3
iRucaparib-TP3 is a non-trapping PARP1 PROTAC degrader with concurrent PARP1 catalytic inhibitory activity. iRucaparib-TP3 induces PARP1 ubiquitination and subsequent proteasomal degradation. iRucaparib-TP3 can be used for the research of cervical adenocarcinoma.
(Pink: PARP-1 ligand (HY-10617A); Blue: Cereblon ligand (HY-10984); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2410557-01-4
- 分子式: C46H52FN9O8
- 分子量:877.96
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
IC50 & Target
[1]|
PARP1 18 nM (IC50) |
体外実験
iRucaparib-TP3 (0.1-20 μM; 24 h) induces highly specific degradation of PARP1 in HeLa cells with minimal off-target proteome perturbation[1].
iRucaparib-TP3 (1-5 μM; 24 h) abrogates PARP1 trapping on chromatin in HeLa cells by degrading PARP1, preventing detectable chromatin-bound PARP1 after methyl methanesulfonate-induced DNA damage[1].
iRucaparib-TP3 (48-72 h) does not induce DNA damage, G2 cell cycle arrest, or impaired cell proliferation in HeLa cells[1].
iRucaparib-TP3 (0.1-50 μM; 24 h) protects C2C12 myotubes, primary rat neonatal cardiomyocytes, and C2C12 myoblasts from genotoxic stress-induced NAD+ and ATP depletion without inducing PARP1 trapping, DNA damage, or impaired cell proliferation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HeLa cells
-
Concentration:0.1 μM, 0.2 μM, 0.5 μM, 1 μM, 2 μM, 5 μM, 10 μM, 20 μM
-
Incubation Time:24 h
-
Result:Induced PARP1 degradation in HeLa cells.
化学情報
-
CAS 番号 2410557-01-4
-
分子量 877.96
-
分子式 C46H52FN9O8
-
SMILES
O=C1NCCC2=C(C3=CC=C(CN(C)CCCCC4=CN(CCOCCOCCOCCNC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)N=N4)C=C3)NC8=CC(F)=CC1=C82
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
iRucaparib-TP3 関連分類
HY-130645 関連分類
Powered by Bioz