製品番号: HY-N0110B

Palmatine hydroxide

10 Cited Publications

カスタマーレビュー

Based on 10 publication(s) in Google Scholar

Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC₅₀s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC₅₀ of 96 μM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.64%
CAS 番号: 131-04-4
分子式: C₂₁H₂₃NO₅
分子量:369.41

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Palmatine hydroxide 構造式

CAS 番号: 131-04-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
Publications (10)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

IDO-1

3 μM (IC₅₀, HEK 293-hIDO-1)

IDO-1

157 μM (IC₅₀, rhIDO-1)

WNV NS2B-NS3

96 μM (IC₅₀)

mAChR アイソフォーム固有の製品をすべて表示 :

Indoleamine 2,3-Dioxygenase (IDO) アイソフォーム固有の製品をすべて表示 :

Aurora Kinase アイソフォーム固有の製品をすべて表示 :

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

Palmatine (0-100 μM; 42 h) suppresses WNV with an EC₅₀ value of 3.6 μM, and reduce the viral titers of DENV-2 and YFV with EC₅₀ values of 26.4 μM and 7.3 μM, respectively^[3].
Palmatine (0-1128 μM; 24-72 h) inhibits colon cancer cell proliferation^[5].
Palmatine (0-704 μM; 24 h) reduces AURKA protein levels, induces G2/M phase arrest, and induces apoptosis in colon cancer cells via the mitochondrial associated pathway^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[5]

Cell Line:

HCT-116, SW480, HT-29
Concentration:

0, 88, 176, 352, and 704 μM (HCT-116, SW480); 0, 141, 282, 564, and 1128 μM (HT-29)
Incubation Time:

24, 48 and 72 h
Result:

Decreased cell viability in a dose-dependent manner.

Western Blot Analysis^[5]

Cell Line:

HCT-116, SW480, HT-29
Concentration:

100 nM for HCT-116, 500 nM for SW480 and HT-29
Incubation Time:

24, 48 and 72 h
Result:

Promoted the expression of apoptosis markers such as P53 / P73, Caspase3, and Caspase9. Reduced AURKA protein levels. Increased cyt. c in the cytoplasm while reduced Bcl2 and Bcl-xl in a dose-dependent manner.

Cell Cycle Analysis^[5]

Cell Line:

HCT-116, SW480
Concentration:

88, 176, 352 and 704 μM
Incubation Time:

24, 48 and 72 h
Result:

Induced G2/M phase arrest in a dose-dependent manner.

Apoptosis Analysis^[5]

Cell Line:

HCT-116, SW480
Concentration:

88, 176, 352 and 704 μM
Incubation Time:

24, 48 and 72 h
Result:

Induced apoptosis in a dose-dependent manner.

体内実験

Palmatine (50 or 100 mg/kg; p.o.; daily for 7 days) ameliorates DSS (dextran sulfate sodium)-induced colitis and prevents infiltration of inflammatory cells^[1].
Palmatine (0-200 mg/kg; i.p.; once) attenuates D-galactosamine/Lipopolysaccharides (HY-D1056)-induced fulminant hepatic failure in mice^[2].
Palmatine (0-1 mg/kg; i.p.; 10 days) shows memory-enhancing activity in mice^[4].
Palmatine (33.75-135 mg/kg; p.o.; daily for 26 days) can effectively inhibit the growth of HCT-116 xenografts in mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

DSS- induced Colitis BALB/c mice model (8-week-old)^[1]
Dosage:

50 or 100 mg/kg
Administration:

Orally, daily, for 7 days
Result:

Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells; remarkably extended the colon length; significantly suppressed the colonic MPO activity. Decreased the levels of colonic inflammatory cytokines (TNF-α, IFN-γ, IL-1β, IL-6, IL-4 and IL-10); Protected mucosal integrity by modulating TJs protein and apoptosis proteins; Restored DSS-induced decreases of TJ protein ZO-1, ZO-2 and claudin-1; Reduced Bax expression and enhanced Bcl-2 expression at the dose of 100 mg/kg, prevented epithelial apoptosis and improved intestinal integrity. Prevented DSS-induced changes of gut microbiota in colitis mice.

Animal Model:

Male ICR mice (20–22 g), D-galactosamine/lipopolysaccharide (GalN/LPS)-induced fulminant hepatic failure model^[2]
Dosage:

25, 50, 100, or 200 mg/kg
Administration:

Intraperitoneal injection, 1 h before the GalN/LPS treatment
Result:

Attenuated the mortality and serum aminotransferase activities increased by GalN/LPS. Prevented the increase of serum TNF-α and augmented that of serum IL-10. Decreased the TNF-a mRNA expression and increased the IL-10 mRNA expression. Attenuated the apoptosis of hepatocytes.

Animal Model:

Swiss young male albino mice, with Scopolamine (HY-N0296)- and diazepam-induced amnesia model^[4]
Dosage:

0.1, 0.5, 1 mg/kg
Administration:

Intraperitoneal injection, 10 days
Result:

Significantly improved learning and memory of mice at 0.5 and 1 mg/kg and did not show any significant effect on locomotor activity of the mice. Significantly reversed scopolamine- and diazepam-induced amnesia in mice. Significantly reduced brain acetylcholinesterase activity of mice.

Animal Model:

BALB/c-nude mice, HCT-116 xenograft model^[5]
Dosage:

33.75, 67.5 and 135 mg/kg
Administration:

Oral administration, once a day for 26 days
Result:

The tumor volume and weight of the treatment group were significantly reduced.

化学情報

CAS 番号 131-04-4
性状 Solid
分子量 369.41
分子式 C₂₁H₂₃NO₅
Color Light yellow to yellow
SMILES

COC(C=C1C2=CC3=CC=C4OC)=C(C=C1CC[N+]2=CC3=C4OC)OC.[OH-]
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (10)

All Bio/Physico-chemical AssayIn Vivo Efficacy StudyHistological Imaging/StainingCell Imaging/Staining

Sort by:

Journal Impact Factor

Phytomedicine

Erzhi pill enhances methotrexate efficacy in rheumatoid arthritis bone homeostasis via activation of the IDO1-KYN-AhR pathway. [Abstract]

2026 May 14:157:158290. PMID: 42208105
Phytomedicine

Huang-Lian-Jie-Du decoction enhances Capecitabine-Oxaliplatin efficacy via Akkermansia muciniphila and CD8+ T cells in colorectal cancer. [Abstract]

2025 Sep 4:148:157233. PMID: 40972261
J Ethnopharmacol

Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. [Abstract]

2024 Jan 30;319(Pt 2):117238. PMID: 37774895
Int Immunopharmacol

Palmatine attenuates the doxorubicin-induced inflammatory response, oxidative damage and cardiomyocyte apoptosis. [Abstract]

2022 May:106:108583. PMID: 35151220
Inflammation

Palmatine Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Suppression of NLRP3 Inflammasome Activation, Pyroptosis, and Metabolic Remodeling. [Abstract]

2025 Dec 20;49(1):11. PMID: 41420798
Biol Res

Palmatine ameliorates high fat diet induced impaired glucose tolerance. [Abstract]

2020 Sep 14;53(1):39. PMID: 32928312

Palmatine hydroxide purchased from MedChemExpress. Usage Cited in: Biol Res. 2020 Sep 14;53(1):39. [Abstract]

Palmatine chloride (PAL) (40 mg/kg; p.o.; once daily for 10 weeks) significantly decreased 2-h blood glucose level in HFD-fed SD rats.

Palmatine hydroxide purchased from MedChemExpress. Usage Cited in: Biol Res. 2020 Sep 14;53(1):39. [Abstract]

Palmatine chloride (PAL) (40 mg/kg; p.o.; once daily for 10 weeks) significantly decreased blood insulin levels in HFD-fed SD rats.

Palmatine hydroxide purchased from MedChemExpress. Usage Cited in: Biol Res. 2020 Sep 14;53(1):39. [Abstract]

Palmatine chloride (PAL) (40 mg/kg; p.o.; once daily for 10 weeks) restored the loss of β cell mass in HFD-fed SD rats, with predominantly increased area that stained positive for insulin.

Palmatine hydroxide purchased from MedChemExpress. Usage Cited in: Biol Res. 2020 Sep 14;53(1):39. [Abstract]

Palmatine chloride (PAL) (40 mg/kg; p.o.; once daily for 10 weeks) remarkably reduced the apoptotic rates in HFD-fed SD rats.
Molecules

Discovery of Nine Dipeptidyl Peptidase-4 Inhibitors from Coptis chinensis Using Virtual Screening, Bioactivity Evaluation, and Binding Studies. [Abstract]

2024 May 14;29(10):2304. PMID: 38792165

Palmatine hydroxide purchased from MedChemExpress. Usage Cited in: Molecules. 2024 May 14;29(10):2304. [Abstract]

The DPP-4 inhibitory activity of Palmatine chloride (10^-7-10^-3 M), demeasured using dose-response curves.
Drug Dev Res

Palmatine attenuates hepatocyte injury by promoting autophagy via the AMPK/mTOR pathway after alcoholic liver disease. [Abstract]

2022 Nov;83(7):1613-1622. PMID: 35976121
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Oxid Med Cell Longev

Palmatine Protects against Cerebral Ischemia/Reperfusion Injury by Activation of the AMPK/Nrf2 Pathway. [Abstract]

2021 Mar 11:2021:6660193. PMID: 33777318

溶剤 & 溶解度

体外:

DMSO : 15.62 mg/mL (42.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7070 mL

13.5351 mL

27.0702 mL

5 mM

0.5414 mL

2.7070 mL

5.4140 mL

10 mM

0.2707 mL

1.3535 mL

2.7070 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (286 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46. [Content Brief]

[2]. Lee WC, et al. Palmatine attenuates D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice. Food Chem Toxicol. 2010 Jan;48(1):222-8. [Content Brief]

[3]. Jia F, et al. Identification of palmatine as an inhibitor of West Nile virus. Arch Virol. 2010 Aug;155(8):1325-9. [Content Brief]

[4]. Dhingra D, et al. Memory-enhancing activity of palmatine in mice using elevated plus maze and morris water maze. Adv Pharmacol Sci. 2012;2012:357368. [Content Brief]

[5]. Liu X, et al. Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA. Biochem Pharmacol. 2020 May;175:113933. [Content Brief]

[6]. Long J, et al. Palmatine: A review of its pharmacology, toxicity and pharmacokinetics. Biochimie. 2019 Jul;162:176-184. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.7070 mL	13.5351 mL	27.0702 mL	67.6755 mL
	5 mM	0.5414 mL	2.7070 mL	5.4140 mL	13.5351 mL
	10 mM	0.2707 mL	1.3535 mL	2.7070 mL	6.7675 mL
	15 mM	0.1805 mL	0.9023 mL	1.8047 mL	4.5117 mL
	20 mM	0.1354 mL	0.6768 mL	1.3535 mL	3.3838 mL
	25 mM	0.1083 mL	0.5414 mL	1.0828 mL	2.7070 mL
	30 mM	0.0902 mL	0.4512 mL	0.9023 mL	2.2558 mL
	40 mM	0.0677 mL	0.3384 mL	0.6768 mL	1.6919 mL

Palmatine hydroxide

10 Cited Publications

100 mg お問い合わせ

Subscribe to the

MedChemExpress

Newsletter

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Palmatine hydroxide

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Metabolism/Protease Compound Library

Neuronal Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Antiviral Compound Library

Autophagy Compound Library

Small Molecule Immuno-Oncology Compound Library

Anti-Aging Compound Library

Antibacterial Compound Library

Orally Active Compound Library

Neurotransmitter Receptor Compound Library

Traditional Chinese Medicine Active Compound Library

Neuroprotective Compound Library

Alkaloids Library

Anti-Blood Cancer Compound Library

Antiparasitic Compound library

Anti-Cancer Natural Product Library

Antiviral Traditional Chinese Medicine Active Compound Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

Protease Inhibitor Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Inhibitors Library

Cell Death Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

Tibetan Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Posttranslational Modification Library

Mongolian Medicine Compound Library

RNA Binding Bioactive Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

MedChemExpress（MCE）の使用を引用している文献 Palmatine hydroxide

mAChR アイソフォーム固有の製品をすべて表示

Indoleamine 2,3-Dioxygenase (IDO) アイソフォーム固有の製品をすべて表示

Aurora Kinase アイソフォーム固有の製品をすべて表示

Parasite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (10)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Palmatine hydroxide 関連分類

HY-N0110B 関連分類