Pirlimycin
Pirlimycin is an orally active lincosamide Antibiotic, Clindamycin (HY-B1455) analog, and antimalarial agent. Pirlimycin inhibits Plasmodium growth. Pirlimycin exhibits antibacterial activity against various aerobic bacteria, particularly Staphylococcus and Streptococcus species. Pirlimycin can be used for research on bovine mastitis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 79548-73-5
- 分子式: C17H31ClN2O5S
- 分子量:410.96
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-17580
FidaxomicinAntibacterial Agent -
HY-B1831A
Oritavancin diphosphateAntibiotic, ArlS Kinase Inhibitor -
HY-P3078
AmphomycinLipopeptide Antibiotic -
HY-N6686
Virginiamycin M1Antibiotic -
HY-17580R
Fidaxomicin (Standard)Antibacterial Agent -
HY-B1831AR
Oritavancin diphosphate (Standard)Antibiotic, ArlS Kinase Inhibitor -
HY-N6686R
Virginiamycin M1 (Standard)Antibiotic
生物活性
製品説明
体外実験
Pirlimycin (0.5-4.0 μg/mL; 20-24 h) exhibits high overall in vitro activity against Streptococcus agalactiae isolates from bovine mastitis (83.7% susceptible, overall MIC50 = 0.5 μg/mL; MIC90 >4 μg/mL)[3].
Pirlimycin (0.5-4.0 μg/mL; 20-24 h) is susceptible to both Cluster Ia and Cluster II Streptococcus agalactiae isolates (MIC50 and MIC90 = 0.5 μg/mL), whereas Cluster Ib isolates show significantly reduced susceptibility[3].
Pirlimycin exhibits in vitro antibacterial activity against a variety of aerobic bacteria, particularly Staphylococcus and Streptococcus species, with MIC values ranging from ≤0.012 to >25 μg/mL[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
Pirlimycin (intramammary injection; 1 h post-infection) combined with rhTNF-α significantly reduces intramammary S. aureus bacterial counts, exhibiting an additive effect compared with either agent alone in a mouse model of staphylococcal mastitis[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CF-1 (male, 18-20 g)[4]
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Dosage:0.4 mg/kg (S. aureus, s.c.); 2.9 mg/kg (S. aureus, p.o.); 0.25 mg/kg (S. pyogenes, s.c.); 2.9 mg/kg (S. pyogenes, p.o.); 1.7 mg/kg (S. pneumoniae I, s.c.); 20.3 mg/kg (S. pneumoniae I, p.o.); 2.7 mg/kg (S. pneumoniae III, s.c.); 17.7 mg/kg (S. pneumoniae III, p.o.); <6.25 mg/kg (B. fragilis, s.c.); 16 mg/kg (P. berghei, s.c.); >50 mg/kg (P. berghei, p.o.)
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Administration:s.c. or p.o.; daily; 4 days
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Result:Demonstrated superior activity to clindamycin against S. aureus, S. pyogenes, and S. pneumoniae.
Achieved CD50 of 0.4 mg/kg (s.c.) and 2.9 mg/kg (p.o.) against S. aureus UC 76.
Achieved CD50 of 0.25 mg/kg (s.c.) and 2.9 mg/kg (p.o.) against S. pyogenes UC 152.
Achieved CD50 of 1.7 mg/kg (s.c.) and 20.3 mg/kg (p.o.) against S. pneumoniae I UC 41.
Achieved CD50 of 2.7 mg/kg (s.c.) and 17.7 mg/kg (p.o.) against S. pneumoniae III UC 3213.
Achieved CD50 of <6.25 mg/kg (s.c.) against Bacteroides fragilis UC 6428.
Achieved CD50 of 16 mg/kg (s.c.) and >50 mg/kg (p.o.) against Plasmodium berghei.
Was inactive at the highest levels tested against K. pneumoniae, P. vulgaris, E. coli, and P. multocida.
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Animal Model:CF1 mice (female, second or third lactation dams with approximately 10 pups each, pups 1-4 d old)[6]
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Dosage:A certain dosage
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Administration:intramammary; 1 h postinfection
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Result:Reduced bacterial counts in the mammary gland to 4.8 log10 cfu/g at 18 h postinfection.
Reduced bacterial counts to 2.8 log10 cfu/g when combined with rhTNF-α (10,000 ng per mouse), which was significantly greater than either agent alone.
化学情報
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CAS 番号 79548-73-5
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分子量 410.96
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分子式 C17H31ClN2O5S
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SMILES
O=C([C@@H]1C[C@@H](CCN1)CC)N[C@]([C@@]2([H])O[C@@H]([C@H](O)[C@@H](O)[C@H]2O)SC)([H])[C@@H](Cl)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Pirlimycin 関連分類
HY-106597 関連分類
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