製品番号: HY-N3519

Platycodin D3

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC₅₀ value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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純度: 98.91%
CAS 番号: 67884-03-1
分子式: C₆₃H₁₀₂O₃₃
分子量:1387.46

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Platycodin D3 構造式

CAS 番号: 67884-03-1

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Amount: USD 0.00

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

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体外実験

Platycodin D3 inhibits the activity of HCV NS5B RdRp with an IC₅₀ of 8 μg/mL, and does not inhibit the activity of HCV NS3/4A protease^[1].
Platycodin D3 (72 h) inhibits RNA replication of HCV genotype 1b in Huh7 replicon cells, with an EC₅₀ of 2.33 μg/mL and a CC₅₀ of 100 μg/mL in Huh7 cells, indicating low cytotoxicity^[1].
Platycodin D3 (48 h) inhibits HCV genotype 2a (JFH1) RNA replication in infected Huh7 cells, with an EC₅₀ of 27 μg/mL^[1].
Platycodin D3 (0.5-5 μg/mL; 3 days) dose-dependently inhibits the expression of HCV NS5A protein in Huh7 cells harboring the subgenomic replicon of HCV genotype 1b^[1].
Platycodin D3 (0-60 μM; 24 h) dose-dependently inhibits nitric oxide production in RAW 264.7 cells activated by LPS (HY-D1056) and IFN-γ, with an IC₅₀ of 55 μM, and shows no cytotoxicity at concentrations up to 60 μM^[2].
Platycodin D3 (20-50 μM; 16-24 h) dose-dependently inhibits iNOS protein expression and upregulates TNF-α mRNA expression in RAW 264.7 cells activated by LPS and IFN-γ^[2].
Platycodin D3 (1-100 μM; 30 min pre-incubation) inhibits the production and secretion of MUC5AC mucin in PMA (HY-18739)-induced NCI-H292 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Huh7 cells harboring HCV genotype 1b subgenomic replicon
Concentration:

0.5, 1, 5 μg/mL
Incubation Time:

3 days
Result:

Prominently reduced HCV NS5A protein expression in a dose-dependent manner.
Resulted in near-complete inhibition of NS5A protein levels relative to untreated controls at 5 μg/mL.

体内実験

Platycodin D3 (20-80 mg/kg/d for 8 weeks) reduces airway hyperresponsiveness, inflammatory responses, and pathological damage in asthmatic mice in a dose-dependent manner in vivo^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (male, 6-8 weeks old, 18-20 g, ovalbumin + aluminum hydroxide-induced asthma)^[4]
Dosage:

20 mg/kg/d; 40 mg/kg/d; 80 mg/kg/d
Administration:

daily; 8 weeks
Result:

Enhanced airway dynamic compliance and reduced total airway resistance in a dose-dependent manner following methacholine challenge.
Reduced total inflammatory cells, eosinophils, macrophages, lymphocytes, and neutrophils in BALF in a dose-dependent manne.
Reduced BALF levels of eotaxin, IL-4, IL-5, IL-13, IFN-γ, and serum IgE in a dose-dependent manner.
Reduced lung tissue inflammatory cell infiltration, mucus hypersecretion, and goblet cell hyperplasia in a dose-dependent manner via HE and PAS staining.
Inhibited phosphorylation of NF-κBp65, p38, ERK1/2, and JNK1/2 proteins in lung tissue.

化学情報

CAS 番号 67884-03-1
性状 Solid
分子量 1387.46
分子式 C₆₃H₁₀₂O₃₃
Color White to off-white
SMILES

OC(C(C(OC1C(C(C(O)CO1)OC2C(C(CO)(O)CO2)O)O)C(C)O3)O)C3OC(C(C(O)CO4)O)C4OC(C56C(CC(C)(C)CC6)C7=CCC(C8(C(C(CO)(C(OC9OC(C(O)C(O)C9O)COC%10OC(C(O)C(O)C%10O)CO)C(O)C8)CO)CC%11)C)C%11(C)C7(C)CC5O)=O
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

純度とドキュメンテーション

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純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kim JW, et al. Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication. Evid Based Complement Alternat Med. 2013;2013:560417. [Content Brief]

[2]. Wang C, et al. Platycodin D and D3 isolated from the root of Platycodon grandiflorum modulate the production of nitric oxide and secretion of TNF-alpha in activated RAW 264.7 cells. Int Immunopharmacol. 2004;4(8):1039-1049. [Content Brief]

[3]. Ryu J, et al. Effects of the root of Platycodon grandiflorum on airway mucin hypersecretion in vivo and platycodin D(3) and deapi-platycodin on production and secretion of airway mucin in vitro. Phytomedicine. 2014;21(4):529-533. [Content Brief]

[4]. Peng F, et al. Protective Effects of Platycodin D3 on Airway Remodeling and Inflammation via Modulating MAPK/NF-κB Signaling Pathway in Asthma Mice. Evid Based Complement Alternat Med. 2022;2022:1612829. Published 2022 Aug 10. [Content Brief]

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Platycodin D3

1 Cited Publications

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Platycodin D3

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MedChemExpress（MCE）の使用を引用している文献 Platycodin D3

Interleukin Related アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

ERK アイソフォーム固有の製品をすべて表示

p38 MAPK アイソフォーム固有の製品をすべて表示

JNK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

純度とドキュメンテーション

参考文献

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