シマジン
Based on 1 Customer Validation
Simazine is a triazine herbicide. Simazine is widely used in agriculture, potted plant and tree production. In addition, Simazine can induce the apoptosis of immune cells in the spleen of mice and inhibit the proliferation of B cells and T cells in mice.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.44%
- CAS 番号: 122-34-9
- 分子式: C7H12ClN5
- 分子量:201.66
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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NF-κB Signaling Compound Library
HY-L014
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Anti-Aging Compound Library
HY-L034
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Anti-Blood Cancer Compound Library
HY-L079
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Mitochondria-Targeted Compound Library
HY-L089
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Human Metabolite Library
HY-L123
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Cell Death Library
HY-L162
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Anti-Hematopathy Compound Library
HY-L171
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Anti-Ovarian Cancer Compound Library
HY-L173
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Multi-Target Compound Library
HY-L176
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Mitophagy Compound Library
HY-L180
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Pesticide Compound Library
HY-L183
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Mass Spectrometry Human Metabolite Library
HY-L215
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Environmental Pollutant Compound Library
HY-L247
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Lactylation Compound Library
HY-L249
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生物活性
Simazine (200-400 μM; 9-12 h) can inhibit the maturation, disrupt the spindle morphology, affect mitochondrial function, increase the level of ROS, and induce DNA damage and early apoptosis of mouse oocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:one-month-old healthy BALB/c mice[2]
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Dosage:0, 90, 200, or 400 mg/kg
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Administration:Oral gavage; 3 weeks
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Result:Reduced proliferation of both spleen T and B cells.
Decreased the number of spleen CD4+ T lymphocytes, while CD8+ T cells remained unchanged.
Reduced immune function, higher intracellular [Ca2+], and oxidative stress.
Induced spleen immune cells apoptosis by reducing Bcl-2, while increasing Fas and Caspase-3 level.
化学情報
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CAS 番号 122-34-9
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性状 Solid
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分子量 201.66
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分子式 C7H12ClN5
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Color White to off-white
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SMILES
CCNC1=NC(Cl)=NC(NCC)=N1
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別名
Simazine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 16.67 mg/mL (82.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (622 KB)
- English - EN (622 KB)
- Français - FR (622 KB)
- Deutsch - DE (622 KB)
- Norwegian - NO (622 KB)
- Español - ES (622 KB)
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- Italian - IT (622 KB)
- Korean - KR (622 KB)
- Portuguese - PT (622 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Shang JZ, et al. Simazine perturbs the maturational competency of mouse oocyte through inducing oxidative stress and DNA damage. Ecotoxicol Environ Saf. 2022 Jan 15;230:113105. [Content Brief]
[2]. Ren R, et al. Oral exposure to the herbicide simazine induces mouse spleen immunotoxicity and immune cell apoptosis. Toxicol Pathol. 2013 Jan;41(1):63-72. [Content Brief]
[3]. Morten T Strandberg, et al. Field Effects of Simazine at Lower Trophic Levels--A Review. ci Total Environ. 2002 Sep 16;296(1-3):117-37. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.9588 mL | 24.7942 mL | 49.5884 mL | 123.9710 mL |
| 5 mM | 0.9918 mL | 4.9588 mL | 9.9177 mL | 24.7942 mL | |
| 10 mM | 0.4959 mL | 2.4794 mL | 4.9588 mL | 12.3971 mL | |
| 15 mM | 0.3306 mL | 1.6529 mL | 3.3059 mL | 8.2647 mL | |
| 20 mM | 0.2479 mL | 1.2397 mL | 2.4794 mL | 6.1986 mL | |
| 25 mM | 0.1984 mL | 0.9918 mL | 1.9835 mL | 4.9588 mL | |
| 30 mM | 0.1653 mL | 0.8265 mL | 1.6529 mL | 4.1324 mL | |
| 40 mM | 0.1240 mL | 0.6199 mL | 1.2397 mL | 3.0993 mL | |
| 50 mM | 0.0992 mL | 0.4959 mL | 0.9918 mL | 2.4794 mL | |
| 60 mM | 0.0826 mL | 0.4132 mL | 0.8265 mL | 2.0662 mL | |
| 80 mM | 0.0620 mL | 0.3099 mL | 0.6199 mL | 1.5496 mL |
Simazine 関連分類
HY-B2046 関連分類
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