Apoptosis inducer 30
Apoptosis inducer 30 (Compound 15a) is an anticancer agent. Apoptosis inducer 30 induces MCF-7 cells apoptosis through mitochondrial pathway. Apoptosis inducer 30 induces intracellular reactive oxygen species levels and decreases mitochondrial membrane potential, and blocks the cell cycle in the G0/G1 phase. Apoptosis inducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and inhibits tumor growth in a mouse model of breast cancer.
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- 화학식: C52H69BrNO4P
- 분자량:882.99
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
IC50 & Target
[1]|
Caspase-9 |
Caspase-7 |
In Vitro
Apoptosis inducer 30 inhibits tumor growth, with IC50s of 1.01, 0.91, 0.32, 0.95, 8.09 μM for A549, HepG2, MCF-7, HeLa, MCF-10A cell respectively[1].
Apoptosis inducer 30 (100-500 nM, 48 h) increases Cyt-C levels in the cytoplasm, and activates caspase-9 and caspase-7 in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 882.99
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화학식 C52H69BrNO4P
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SMILES
CC(C)[C@H](C)/C=C/[C@@H](C)[C@H]1CCC2[C@@]34C=C[C@@]5(OO4)C[C@@H](OC(NCCCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=O)CC[C@]5(C)C3CC[C@@]21C.[Br-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Apoptosis inducer 30 Related Classifications
HY-168589 Related Classifications
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