Cannabitwinol
Cannabitwinol is a selective thermosensitive TRP modulator and NF-κB inhibitor. Cannabitwinol inhibits TNFα-induced NF-κB-driven transcription and TNFα-induced IL-8 release, and exhibits anti-inflammatory and antioxidant activities. Cannabitwinol shows selectivity for cold-activated TRP channels, activating TRPA1 (EC50 = 3.0 μM) and antagonizing TRPM8 (IC50 = 3.9 μM), but has no significant affinity for heat-activated TRP channels such as TRPV1 and TRPV2. Cannabitwinol can be used in research related to inflammatory skin diseases, cold allodynia, and hyperalgesia.
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- CAS No.: 2699950-81-5
- 화학식: C43H60O4
- 분자량:640.93
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
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NF-κB |
IL-8 |
TRPA1 3.0 μM (EC50) |
TRPM8 3.9 μM (IC50) |
In Vitro
Cannabitwinol (0.5-20 μM; 6 h) inhibits TNFα-induced IL-8 release (IC50 = 6.39 μM) and NF-κB-driven transcription (IC50 = 19.8 μM) in HaCaT cells, with significant NF-κB inhibition observed at 20 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCaT human keratinocytes
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Concentration:0.5, 1, 2.5, 5, 10 and 20 μM
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Incubation Time:6 h (cotreatment with TNFα)
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Result:Inhibited TNFα-induced IL-8 release with an IC50 of 6.39 μM in a concentration-dependent manner.
Inhibited TNFα-induced NF-κB-driven transcription with an IC50 of 19.8 μM, with a statistically significant effect observed only at 20 μM.
Chemical Information
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CAS No. 2699950-81-5
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분자량 640.93
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화학식 C43H60O4
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SMILES
CC([C@H]1[C@H](C2=C(C(CC3=C(C=C(C([C@H]4[C@@H](CCC(C)=C4)C(C)=C)=C3O)O)CCCCC)=C(C=C2O)CCCCC)O)C=C(CC1)C)=C
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Synonyms
CBDD
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (276 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1].
Pozzi L, et al. Cannabizetol, a Novel Cannabinoid: Chemical Synthesis, Anti-inflammatory Activity and Extraction from Cannabis sativa L. J Nat Prod. 2025 Oct 24;88(10):2451-2459.
[Content Brief]
[2].
Chianese G, et al. Cannabitwinol, a Dimeric Phytocannabinoid from Hemp, Cannabis sativa L., Is a Selective Thermo-TRP Modulator. J Nat Prod. 2020 Sep 25;83(9):2727-2736.
[Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cannabitwinol Related Classifications
HY-179432 Related Classifications
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