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Cat. No.: HY-168863

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FF2049

FF2049 is a selective HDAC PROTAC degrader (DC₅₀ = 257 nM for HDAC1). FF2049 promotes ubiquitination and degradation of HDAC. FF2049 promotes Apoptosis. FF2049 can be used for the research of hematological and solid cancer.
(Pink: HDAC ligand (HY-168864); Blue: FEM1B ligand (HY-168865); Black: linker (HY-Y0966)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₁H₃₈ClN₇O₇
분자량:656.13

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

FF2049 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

FF2049 is a selective HDAC PROTAC degrader (DC₅₀ = 257 nM for HDAC1). FF2049 promotes ubiquitination and degradation of HDAC. FF2049 promotes Apoptosis. FF2049 can be used for the research of hematological and solid cancer^[1]. (Pink: HDAC ligand (HY-168864); Blue: FEM1B ligand (HY-168865); Black: linker (HY-Y0966)).

All PROTACs Isoforms :

All HDAC Isoforms :

Chemical Information

분자량 656.13
화학식 C₃₁H₃₈ClN₇O₇
SMILES

ONC(CCCCCCNC(C1=CC=C(C=C1)NC(CNC(CN2CCOC3=C2C=CC(N(C(CCl)=O)CCC#N)=C3)=O)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Feller F, et al. Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders. J Med Chem. 2025 Jan 13. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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수량:
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FF2049

All PROTACs Isoforms

All HDAC Isoforms