2. Metabolic Enzyme/Protease
  3. Glutathione S-transferase
  4. Phorone

Phorone  (Synonyms: Diisopropylidene acetone)

Cat. No.: HY-W017785 Purity: 99.79%
COA
SDS
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Phorone (Diisopropylidene acetone) is a glutathione (GSH) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding (Glutathione S-transferase) (Km = 0.9 mM). Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.

For research use only. We do not sell to patients.

Phorone

Phorone Chemical Structure

CAS No. : 504-20-1

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Based on 1 publication(s) in Google Scholar

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Description

Phorone (Diisopropylidene acetone) is a glutathione (GSH) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding (Glutathione S-transferase) (Km = 0.9 mM). Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.

Molecular Weight

138.21

Formula

C9H14O
CAS No.
Appearance

<28°C Solid,>28°C Liquid

Color

Colorless to light yellow

SMILES

O=C(/C=C(C)/C)/C=C(C)\C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.9%

SDS (393 KB)

COA (244 KB) HNMR (109 KB) GC (217 KB)

Handling Instructions (2659 KB)
References
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Phorone Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phorone504-20-1Diisopropylidene acetoneGlutathione S-transferaseGlutathione transferasesGSTsglutathione depletionhepatotoxicitysynergistic effectsbromobenzeneparacetamolGSH S-transferaseserum transaminasescentrilobular necrosisdose thresholdInhibitorinhibitorinhibit

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