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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
529 Results for "
AGE
" in MedChemExpress (MCE) Product Catalog:
Products (529)
529 Results for "AGE" in MCE Product Catalog:
286
Target:
研究分野:
Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis . Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation .
179
179 Cited Publications
MitoTEMPO hydrate is a mitochondria-targeted antioxidant . MitoTEMPO hydrate induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. MitoTEMPO hydrate regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. MitoTEMPO hydrate reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. MitoTEMPO hydrate can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
179
179 Cited Publications
Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. Mito-TEMPO can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
172
50
50 Cited Publications
製品番号: HY-W250163
CAS 番号: 64417-72-7
別名: β-DPN lithium; β-NAD lithium; β-Nicotinamide Adenine Dinucleotide lithium
32
Category:
Monophenols Orchidaceae Ketones, Aldehydes, Acids Phenols Anoectochilus roxburghii (Wall.) Lindl. Plants Disease Research Fields Cancer
Target:
31
31 Cited Publications
SB 239063 is a potent, selective and orally active p38 MAPK inhibitor, exhibits an IC50 of 44 nM for recombinant purified human p38α, with equipotent inhibitory activity against p38α and p38β. SB 239063 has no effect on p38γ or p38δ. With anti-asthma activity and also be used to enhance memory which is impaired due to aging or medical conditions, such as, AD. SB 239063 can penetrate the blood brain barrier (BBB) .
16
16 Cited Publications
別名: Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt
14
14 Cited Publications
12
12 Cited Publications
Target:
研究分野:
NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues . NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice .
11
Category:
Infection Eucommia ulmoides Oliver Neurological Disease Iridoids Terpenoids Eucommiaceae Plants Disease Research Fields Inflammation/Immunology
Target:
11
11 Cited Publications
製品番号: HY-N0033
CAS 番号: 94079-81-9
Category:
Cardiovascular Disease Callicarpa formosana Rolfe Plants Simple Phenylpropanols Verbenaceae Scrophulariaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology Brandisia hancei Hook. f.
Target:
10
10 Cited Publications
別名: PimAGEdine hydrochloride; GER-11; Aminoguanidinium chloride
Target:
Aminoguanidine (Pimagedine) hydrochloride is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hydrochloride can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in the research of diabetic nephropathy .
9
Category:
Target:
7
Category:
天然物 other families Neurological Disease Plants Phytohormone Disease Research Fields Cytokinin Agricultural Research
Target:
7
Category:
Infection Flavonoids Monophenols Leguminosae Glycine max (L.) merr Phenols Plants Disease Research Fields Isoflavones
Target:
6
Target:
6
Category:
Human Gut Microbiota Metabolites 天然物 Microorganisms Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields
Target:
6
Target:
6
Target:
研究分野:
PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
