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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
fatty acid synthesis pathway
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "fatty acid synthesis pathway" in MCE Product Catalog:
6
2
2 Cited Publications
Synonyms: Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid
Category:
Immune System Disorder Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields
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1
1 Cited Publications
Cat. No.: HY-N0468
CAS No.: 63279-13-0
Category:
other families Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Sweeteners Food Research
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Cat. No.: HY-W015924
CAS No.: 594-61-6
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3-Hydroxybutyrate dehydrogenase (3-HBDH), a mitochondrial enzyme, is a key enzyme in the ketone body metabolism pathway. 3-Hydroxybutyrate dehydrogenase is the last enzyme for ketone synthesis in the liver and the first enzyme for ketone breakdown in extracellular tissues. The absence of 3-Hydroxybutyrate dehydrogenase leads to the inhibition of fatty acid oxidation in the liver during fasting in mice, resulting in lipid accumulation and the development of fatty liver .
Cat. No.: HY-N7392A
Synonyms: 3-Oxobutanoyl-coenzyme A sodium hydrate
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Category:
Human Gut Microbiota Metabolites Metabolic Disease Endogenous metabolite Disease Research Fields
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Cat. No.: HY-148009
CAS No.: 2260669-35-8
Synonyms: 16:0-18:1 Cardiolipin sodium
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Cardiolipin (16:0/18:1/16:0/18:1) (16:0-18:1 Cardiolipin) sodium is a di-saturated mitochondrial-specific anionic phospholipid sodium salt containing the long-chain fatty acid palmitic acid (HY-N0830) and the monounsaturated fatty acid oleic acid (HY-N1446). Cardiolipin (16:0/18:1/16:0/18:1) sodium undergoes in-source fragmentation via diglyceride (DG)-H2O fragment formation and (DG-H2O) fragment loss pathways. Cardiolipin (16:0/18:1/16:0/18:1) sodium can be used in the synthesis of lipid nanodiscs for application in in situ mass spectrometry .
Cat. No.: HY-112747
CAS No.: 97281-51-1
Synonyms: LPI; PE (soy)
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Soy PE (LPI) is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial membranes, respectively. It is a precursor in the synthesis of phosphatidylcholine and arachidonoyl ethanolamide and is a source of ethanolamine used in various cellular functions. In E.coli, phosphatidylethanolamine deficiency prevents proper assembly of lactose permease, suggesting a role as a lipid chaperone. It is a cofactor in the propagation of prions in vitro and can convert recombinant mammalian proteins into infectious molecules even in the absence of RNA. This product contains phosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 and sn-2 positions .
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CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimer's disease (AD) targeted agent J147 (HY-13779) (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer's disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice .
Cat. No.: HY-W015924R
CAS No.: 594-61-6
Cat. No.: HY-24547
CAS No.: 331649-59-3
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HpFabZ-IN-1 (Compound 1) is an inhibitor of the key enzyme FabZ in the Helicobacter pylori fatty acid synthesis pathway, with its IC50 value being 39.8 µM. HpFabZ-IN-1 does not possess antibacterial activity .
Cat. No.: HY-N0468R
CAS No.: 63279-13-0
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Cat. No.: HY-E71774
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3-Oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) is an NADPH-dependent β-ketoacyl-ACP reductase and a key enzyme in the bacterial type II fatty acid synthesis pathway.
Cat. No.: HY-Y1139S2
CAS No.: 78629-92-2
Synonyms: Heptanedioic acid-13C2; 1,5-Pentanedicarboxylic acid-13C2; 1,7-Heptanedioic acid--13C2
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Pimelic acid- 13C2 (Heptanedioic acid- 13C2) is the 13C-labeled Pimelic acid (HY-Y1139). Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism .
Cat. No.: HY-W563489
CAS No.: 88431-47-4
Synonyms: POCA
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Clomoxir (POCA) is a carnitine palmitoyltransferase I (CPT I) inhibitor with hypoglycemic activity. Clomoxir mediates the inhibition of CPT I via its active form POCA-CoA. Clomoxir inhibits long-chain fatty acid oxidation, ketogenesis, gluconeogenesis, de novo synthesis of cholesterol and fatty acids, and also mildly inhibits acetyl-CoA carboxylase. Clomoxir reduces blood glucose levels in various rodent and porcine models, alters plasma NEFA and cholesterol concentrations, induces hepatic lipid accumulation, peroxisome proliferation and mild myocardial hypertrophy in rats, and stimulates the pentose phosphate pathway in cultured human fibroblasts. Clomoxir can be used in diabetes-related research .
Cat. No.: HY-183279
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FXR antagonist 4 (Compound 4l) is an orally active, selective FXR antagonist with an IC50 of 0.70 μM. FXR antagonist 4 binds to FXR, differentially regulates bile acid and lipid transporter genes, and exerts no effect on gluconeogenesis-related genes. FXR modulator 1 activates the AMPK signaling pathway to inhibit fatty acid synthesis. FXR modulator 1 alleviates hepatic steatosis, ballooning degeneration and fibrosis, and improves dyslipidemia. FXR modulator 1 can be used for research on metabolic dysfunction-associated steatohepatitis .
Cat. No.: HY-L064
1,827 compounds
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.
Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.
MCE owns a unique collection of 1,827 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
