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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
191 Results for "
modulation
" in MedChemExpress (MCE) Product Catalog:
Products (191)
191 Results for "modulation" in MCE Product Catalog:
60
60 Publications Verification
Synonyms: PGE2; Dinoprostone
22
Category:
Neurological Disease Metabolic Disease Plants Endogenous metabolite Human Gut Microbiota Metabolites Iridoids Terpenoids Rubiaceae Gardenia jasminoides Ellis Disease Research Fields Inflammation/Immunology
Target:
22
22 Cited Publications
Synonyms: Z/E-Guggulsterone
20
20 Cited Publications
Synonyms: 2-Aminoethanesulfonic acid
Category:
Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer
Target:
13
13 Cited Publications
Synonyms: BL-191; PTX; Oxpentifylline
Category:
Target:
12
12 Cited Publications
Referencia número: HY-106224B
Pureza: 99.93%
Synonyms: Hypocretin-1 (human, rat, mouse) acetate
Target:
Áreas de investigación:
12
12 Cited Publications
Synonyms: ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3
Target:
Áreas de investigación:
α-Linolenic acid sodium (ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3) is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid sodium can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid sodium possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer .
12
12 Cited Publications
Synonyms: ALA free base; C18:3 (9Z,12Z,15Z) free base; C18:3 n-3 free base
Category:
Cardiovascular Disease Natural Products Labiatae Ulex europaeus L. Disease markers Plants Endogenous metabolite Disease Research Fields Cardiovascular System Disorder
Target:
10
10 Cited Publications
Synonyms: Genistine; Genistoside; Genistein 7-O-β-D-glucopyranoside
Category:
Flavonoids Leguminosae Glycine max (L.) merr Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Isoflavones
Target:
10
10 Cited Publications
Synonyms: 6-Methoxynicotinamide
Target:
Áreas de investigación:
JBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent and orally active Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease .
8
8 Cited Publications
Referencia número: HY-19870C
No. CAS: 2759937-80-7
Synonyms: RM-493 monoacetate; BIM-22493 monoacetate; IRC-022493 monoacetate
Target:
Áreas de investigación:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
7
Áreas de investigación:
Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects .
5
Target:
Áreas de investigación:
Tropisetron Hydrochloride (SDZ-ICS-930) is an effective neuroprotective agent that acts as a 5-HT3 receptor antagonist, a calmodulin inhibitor, and an α7-nAChRreceptor agonist, with an IC50 of 70.1 nM for the 5-HT3 receptor. Tropisetron Hydrochloride has anti-inflammatory properties and immune-regulating functions, effectively alleviating symptoms associated with chemotherapy and post-surgery. Tropisetron Hydrochloride reduces Ab (HY-P4867)-induced hippocampal neuroinflammation .
4
4 Cited Publications
Referencia número: HY-B1193
No. CAS: 50679-08-8
Synonyms: (±)-Terfenadine; MDL-991
Áreas de investigación:
Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM . Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca 2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9 .
3
3 Cited Publications
Áreas de investigación:
WZ811 is an orally active, highly potent competitive antagonist of CXCR4. WZ811 efficiently inhibits CXCR4/SDF-1 (or CXCL12)-mediated modulation of cAMP levels (EC50=1.2 nM) and SDF-1 induced Matrigel invasion in cells (EC50=5.2 nM) .
3
3 Cited Publications
UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1a can be used for epitranscriptomic modulation of cellular processes. UZH1a has antitumor activity. UZH1a also can be used as a chemical probe for studying METTL3 .
3
3 Cited Publications
UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1b (IC50=28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor activity. UZH1 also can be used as a chemical probe for studying METTL3 .
2
2 Cited Publications
Synonyms: 5,10-Methylenetetrafolate; ANX-510 free acid
Target:
2
2 Cited Publications
Referencia número: HY-113679
No. CAS: 100403-19-8
Target:
Áreas de investigación:
Ceramides Mixture is an endogenous ceramide and consists of hydroxy and non-hydroxy fatty acid-containing ceramides. Ceramides Mixture is a main lipid component of the permeability barrier in epidermis. Ceramides Mixture is involved in the regulation of growth inhibition, cell cycle arrest, and modulation of telomerase activity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
