1386 Results for "

replication

" in MedChemExpress (MCE) Product Catalog:
Products (1386)

1386 Results for "replication" in MCE Product Catalog:

226
Oxaliplatin
Oxaliplatin
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226 Publications Verification
Cat. No.: HY-17371
CAS No.: 61825-94-3
Target:  

DNA/RNA Synthesis Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Oxaliplatin is a DNA synthesis inhibitor. Oxaliplatin causes DNA crosslinking damage, prevents DNA replication and transcription and induces apoptosis. Oxaliplatin can be used for cancer research .
180
Etoposide
Etoposide
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180 Cited Publications
Cat. No.: HY-13629
CAS No.: 33419-42-0
Purity:  99.94%
Synonyms: VP-16; VP-16-213
Category:  

Infection Monophenols Sinopodophyllum hexandrum (Royle) Ying Lignans Phenols Phenylpropanoids Plants Berberidaceae Disease Research Fields

Target:  

Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic

Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .
142
Thapsigargin
Thapsigargin
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142 Cited Publications
Cat. No.: HY-13433
CAS No.: 67526-95-8
Purity:  99.87%
Category:  

Infection Terpenoids Diterpenoids Plants Umbelliferae Disease Research Fields Cancer Thapsia garganica L.

Target:  

Calcium Channel SARS-CoV Apoptosis

Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca 2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .
118
Sofosbuvir
Sofosbuvir
0 Images
118 Cited Publications
Cat. No.: HY-15005
CAS No.: 1190307-88-0
Purity:  99.97%
Synonyms: GS-7977; PSI-7977
Target:  

HCV

Research Areas:  

Infection Cancer

Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM .
106
Plerixafor
Plerixafor
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106 Cited Publications
Cat. No.: HY-10046
CAS No.: 110078-46-1
Purity:  99.90%
Synonyms: AMD 3100; JM3100; SID791
Target:  

CXCR HIV

Research Areas:  

Infection Inflammation/Immunology Endocrinology Cancer

Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM .
94
Carboplatin
Carboplatin
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94 Cited Publications
Cat. No.: HY-17393
CAS No.: 41575-94-4
Synonyms: NSC 241240
Target:  

DNA Alkylator/Crosslinker Autophagy DNA/RNA Synthesis

Research Areas:  

Cancer

Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.
75
Vincristine
Vincristine
0 Images
75 Cited Publications
Cat. No.: HY-N0488A
CAS No.: 57-22-7
Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
Category:  

Apocynaceae Alkaloids Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:  

Apoptosis Microtubule/Tubulin Mitosis

Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
75
Vincristine sulfate
Vincristine sulfate
0 Images
75 Cited Publications
Cat. No.: HY-N0488
CAS No.: 2068-78-2
Synonyms: Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate
Category:  

Apocynaceae Alkaloids Anti-aging Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:  

Apoptosis Microtubule/Tubulin Mitosis

Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) sulfate is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
49
Baloxavir
Baloxavir
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49 Cited Publications
Cat. No.: HY-109025A
CAS No.: 1985605-59-1
Purity:  99.68%
Synonyms: Baloxavir acid; S-033447
Target:  

Influenza Virus

Research Areas:  

Infection Cancer

Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
48
Ivermectin
Ivermectin
0 Images
48 Cited Publications
Cat. No.: HY-15310
CAS No.: 70288-86-7
Purity:  98.28%
Synonyms: MK-933; CD-5024; K-237
Category:  

Microorganisms Macrolide Antibiotics Antibiotics Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer

Target:  

Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus

Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .
45
Simeprevir
Simeprevir
0 Images
45 Cited Publications
Cat. No.: HY-10241
CAS No.: 923604-59-5
Purity:  98.79%
Synonyms: TMC435; TMC435350
Target:  

HCV HCV Protease SARS-CoV DNA/RNA Synthesis

Research Areas:  

Infection

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .
42
Bardoxolone methyl
Bardoxolone methyl
0 Images
42 Cited Publications
Cat. No.: HY-13324
CAS No.: 218600-53-4
Purity:  98.92%
Synonyms: RTA 402; NSC 713200; CDDO Methyl ester
Target:  

Keap1-Nrf2 SARS-CoV Virus Protease

Research Areas:  

Infection Neurological Disease Inflammation/Immunology

Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC50 value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) .
42
Niclosamide
Niclosamide
0 Images
42 Cited Publications
Cat. No.: HY-B0497
CAS No.: 50-65-7
Synonyms: BAY2353
Target:  

Environmental Pollutants Antibiotic Parasite STAT

Research Areas:  

Infection Cancer

Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells .
42
Niclosamide olamine
Niclosamide olamine
0 Images
42 Cited Publications
Cat. No.: HY-B0497C
CAS No.: 1420-04-8
Synonyms: BAY2353 olamine
Target:  

Environmental Pollutants Antibiotic STAT Parasite

Research Areas:  

Infection Cancer

Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research . Niclosamide olamin is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells . Niclosamide olamin has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .
41
EIDD-1931
EIDD-1931
0 Images
41 Cited Publications
Cat. No.: HY-125033
CAS No.: 3258-02-4
Purity:  99.96%
Synonyms: β-D-N4-hydroxycytidine; NHC
Target:  

CHIKV SARS-CoV Enterovirus HCV Topoisomerase

Research Areas:  

Infection

EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) .
36
Prexasertib
Prexasertib
0 Images
36 Cited Publications
Cat. No.: HY-18174
CAS No.: 1234015-52-1
Synonyms: LY2606368
Target:  

Checkpoint Kinase (Chk) Apoptosis

Research Areas:  

Cancer

Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity .
36
Prexasertib dihydrochloride
Prexasertib dihydrochloride
0 Images
36 Cited Publications
Cat. No.: HY-18174A
CAS No.: 1234015-54-3
Synonyms: LY2606368 dihydrochloride
Target:  

Checkpoint Kinase (Chk) Apoptosis

Research Areas:  

Cancer

Prexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib dihydrochloride inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dihydrochloride shows potent anti-tumor activity .
36
Prexasertib dimesylate
Prexasertib dimesylate
0 Images
36 Cited Publications
Cat. No.: HY-18174E
CAS No.: 1234015-58-7
Synonyms: LY2606368 dimesylate
Target:  

Checkpoint Kinase (Chk) Apoptosis

Research Areas:  

Cancer

Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib dimesylate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dimesylate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dimesylate shows potent anti-tumor activity .
35
5-Ethynyl-2'-deoxyuridine
5-Ethynyl-2'-deoxyuridine
0 Images
35 Cited Publications
Cat. No.: HY-118411
CAS No.: 61135-33-9
Purity:  99.78%
Synonyms: EdU
Target:  

PROTAC Linkers

Research Areas:  

Cancer

5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation . 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
35
Dolutegravir
Dolutegravir
0 Images
35 Cited Publications
Cat. No.: HY-13238
CAS No.: 1051375-16-6
Purity:  99.85%
Synonyms: S/GSK1349572
Target:  

HIV Integrase HIV

Research Areas:  

Infection

Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM) .
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