624 Results for "

triterpenoid

" in MedChemExpress (MCE) Product Catalog:

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Glycyrrhizic acid

67 Publications Verification

Cat. No.: HY-N0184

CAS No.: 1405-86-3

Synonyms: Glycyrrhizin

Category:

Triterpenes Terpenoids Metabolic Disease Leguminosae Extract Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Sweeteners Food Research

Target:

Virus Protease

Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.

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Betulinic acid

38 Cited Publications

Cat. No.: HY-10529

CAS No.: 472-15-1

Purity: 99.06%

Synonyms: Lupatic acid; Betulic acid

Category:

Infection Triterpenes Terpenoids Plants Other Families Extract Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite

Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties . Betulinic acid can cross the blood-brain barrier .

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Ursolic acid

21 Cited Publications

Cat. No.: HY-N0140

CAS No.: 77-52-1

Synonyms: Prunol; Urson; Malol

Category:

Triterpenes Terpenoids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Endogenous metabolite Disease Research Fields Rhamnaceae Extract Cancer

Target:

Autophagy Endogenous Metabolite

Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

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Cucurbitacin B

13 Cited Publications

Cat. No.: HY-N0416

CAS No.: 6199-67-3

Category:

Triterpenes Terpenoids Trichosanthes cucumerina L. Cucurbitaceae Extract Plants Endogenous metabolite Disease Research Fields Cancer

Target:

HIF/HIF Prolyl-Hydroxylase Integrin Autophagy Apoptosis Endogenous Metabolite ROS Kinase COX

Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity .

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Hederagenin

8 Cited Publications

Cat. No.: HY-N0256

CAS No.: 465-99-6

Category:

Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Terpenoids Plants Disease Research Fields Cancer Araliaceae Extract

Target:

COX NF-κB E1/E2/E3 Enzyme

Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin can also bind to SKP2, with K_D = 67.9 μM. Hederagenin also has preventive potential against alcoholic liver injury .

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Toosendanin

6 Cited Publications

Cat. No.: HY-N0263

CAS No.: 58812-37-6

Category:

Triterpenes Terpenoids Melia toosendan Sieb. et Zucc. Meliaceae Extract Plants Disease Research Fields Inflammation/Immunology

Target:

Others

Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

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Demethylzeylasteral

6 Cited Publications

Cat. No.: HY-N0587

CAS No.: 107316-88-1

Category:

Triterpenes Celastraceae Extract Terpenoids Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology

Target:

Apoptosis TGF-beta/Smad Estrogen Receptor/ERR NF-κB FAK

Demethylzeylasteral is an orally active triterpenoid compound isolated from Tripterygium wilfordii, which has functions such as anti-inflammatory, anti-tumor, anti fertility, estrogen metabolism regulation, immune suppression, and immune system regulation ^[1][2].

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Lupeol

6 Cited Publications

Cat. No.: HY-N0790

CAS No.: 545-47-1

Synonyms: Clerodol; Monogynol B; Fagarasterol

Category:

Triterpenes Terpenoids Plants Other Families Extract Disease Research Fields Cancer

Target:

Androgen Receptor Apoptosis

Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) .

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Pachymic acid

5 Cited Publications

Cat. No.: HY-N0371

CAS No.: 29070-92-6

Synonyms: 3-O-Acetyltumulosic acid

Category:

Triterpenes Terpenoids Polyporaceae Extract Poria cocos Plants Disease Research Fields Cancer

Target:

Akt ERK

Pachymic acid is a lanostrane-type triterpenoid from P. cocos. Pachymic acid inhibits Akt and ERK signaling pathways.

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Momordin Ic

5 Cited Publications

Cat. No.: HY-N0330

CAS No.: 96990-18-0

Category:

Kochia scoparia L. Schrad. Triterpenes Terpenoids Chenopodiaceae Extract Plants Disease Research Fields Cancer

Target:

Apoptosis Autophagy PI3K c-Myc

Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl₄ (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

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Alisol A

5 Cited Publications

Cat. No.: HY-N0853

CAS No.: 19885-10-0

Category:

Triterpenes Alisma plantago-aquatica Linn. Terpenoids Other Diseases Plants Disease Research Fields Alismataceae Extract

Target:

AMPK Acetyl-CoA Carboxylase PPAR MMP Interleukin Related

Alisol A is an orally active tetracyclic triterpenoid compound of the prototerpane type. Alisol A can be extracted from the rhizome of Alisma orientale. Alisol A activates AMPK/ACC/SREBP-1c, SIRT1, PPARα, inhibits MMP-2/-9, decreases inflammatory cytokine expression (IL-1β, IL-6, IL-8). Alisol A has anti-tumor activity against breast cancer and colorectal cancer. Alisol A has anti-obesity and anti-atherosclerotic activities. Alisol A can be used in the research of hepatitis B, breast cancer, colorectal cancer, atherosclerosis, and obesity .

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AKBA

4 Cited Publications

Cat. No.: HY-N0892

CAS No.: 67416-61-9

Synonyms: Acetyl-11-keto-β-boswellic acid

Category:

Triterpenes Terpenoids Burseraceae Extract Boswellia serrata Plants Disease Research Fields Cancer

Target:

HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species (ROS) Endogenous Metabolite

AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.

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Taraxasterol

4 Cited Publications

Cat. No.: HY-N1178

CAS No.: 1059-14-9

Category:

Triterpenes Terpenoids Astragalus oleifolius DC. Plants Compositae Extract Disease Research Fields Inflammation/Immunology

Target:

Interleukin Related LXR

Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases .

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Obacunone

4 Cited Publications

Cat. No.: HY-N0428

CAS No.: 751-03-1

Category:

Rutaceae Extract Triterpenes Terpenoids Plants Disease Research Fields Citrus Cancer

Target:

Apoptosis

Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

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alpha-Hederin

4 Cited Publications

Cat. No.: HY-N0255

CAS No.: 27013-91-8

Synonyms: α-Hederin

Category:

Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Extract

Target:

Apoptosis

alpha-Hederin (α-Hederin), a monodesmosidic triterpenoid saponin, exhibits promising antitumor potential against a variety of human cancer cell lines. alpha-Hederin could inhibit the proliferation and induce apoptosis of gastric cancer accompanied by glutathione decrement and reactive oxygen species generation via activating mitochondrial dependent pathway .

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Alisol B 23-acetate

4 Cited Publications

Cat. No.: HY-N0805

CAS No.: 26575-95-1

Synonyms: 23-Acetylalismol B; 23-O-Acetylalisol B; Alisol B monoacetate

Category:

Triterpenes Alisma plantago-aquatica Linn. Terpenoids Other Diseases Plants Disease Research Fields Alismataceae Extract

Target:

Apoptosis Reactive Oxygen Species (ROS) CDK MMP PARP FXR Syk

Alisol B 23-acetate is an orally active prototerpane-type triterpenoid. Alisol B 23-acetate can be isolated from Alisma orientalis. Alisol B 23-acetate induces Apoptosis, promotes ROS generation, downregulates CDK4/6, MMP-2/9, upregulates cleaved PARP, activates FXR and inhibits Syk. Alisol B 23-acetate has anti-inflammatory and hepatoprotective activities. Alisol B 23-acetate protects the kidney from ischemia-reperfusion injury. Alisol B 23-acetate has anticancer activity against ovarian cancer, colon cancer, lung cancer, and gastric cancer. Alisol B 23-acetate can be used in the study of atherosclerosis and allergic asthma .

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Deapioplatycodin D

3 Cited Publications

Cat. No.: HY-N0588

CAS No.: 78763-58-3

Category:

Infection Campanulaceae Extract Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Plants Disease Research Fields

Target:

HCV

Deapioplatycodin D is a triterpenoid saponin isolated from Platycodon grandiflorum, with anti-HCV activity .

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Escin

3 Cited Publications

Cat. No.: HY-B2114

CAS No.: 6805-41-0

Category:

Triterpenes Hippocastanaceae Extract Terpenoids Aesculus hippocastanum Plants Saccharides

Target:

Apoptosis

Escin, a natural compound of triterpenoid saponins that can be isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent .

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Azadirachtin

3 Cited Publications

Cat. No.: HY-126741

CAS No.: 11141-17-6

Purity: 99.06%

Category:

Triterpenes Terpenoids Other Diseases Meliaceae Extract Plants Azadirachta indica A. Juss. Disease Research Fields Biological Pesticide Research Agricultural Research

Target:

Environmental Pollutants Parasite Caspase NF-κB Apoptosis Bcl-2 Family

Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells .

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Platycodin D2

3 Cited Publications

Cat. No.: HY-N4087

CAS No.: 66663-90-9

Category:

Campanulaceae Extract Triterpenes Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Plants Disease Research Fields Cancer

Target:

Mitophagy Autophagy Ferroptosis Interleukin Related IFNAR Reactive Oxygen Species (ROS)

Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology .

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