Interleukin Related
IL
Interleukins are a group of cytokines (secreted proteins and signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice.
Interleukin Related Isoform Specific Products
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Interleukin Related
(949)
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IL-1
(483)
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IL-2
(116)
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IL-3
(8)
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IL-4
(89)
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IL-5
(34)
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IL-6
(506)
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IL-8
(103)
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IL-10
(95)
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IL-12
(39)
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IL-13
(56)
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IL-15
(10)
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IL-17
(107)
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IL-23
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IL-7
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IL-33
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IL-22
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IL-18
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Interleukin Related Inhibitors
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Interleukin Related Agonists
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Interleukin Related Antagonists
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Interleukin Related Activators
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Interleukin Related Modulators
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Interleukin Related Chemicals
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Interleukin Related Inducers
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Interleukin Related Degraders
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Interleukin Related Controls
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Interleukin Related Ligands
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IL-4 Proteins
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IL-12 Proteins
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IL-17 Proteins
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IL-8/CXCL8 Proteins
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Multi-CSF/IL-3 Proteins
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IL-1 Proteins
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IL-2 Proteins
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IL-5 Proteins
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IL-6 Proteins
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IL-10 Proteins
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IL-13 Proteins
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IL-15 Proteins
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IL-23 Proteins
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Interleukin Related Related Products (2249)
Related Products (2249)
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Recombinant Proteins (352)
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Antibodies (36)
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Interleukin Related Isoform Comparison
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AHL-7160
0 ImagesCat. No.: HY-180898AHL-7160 is a molecular glue degrader targeting DGKα, with an IC50 value of 12 nM against the human protein. AHL-7160 rapidly recruits DGKα to the plasma membrane, blocks DGKα-mediated phosphatidic acid production, and induces proteasome-dependent degradation of DGKα with full proteome selectivity. AHL-7160 enhances primary T cell-mediated glioblastoma cell killing. AHL-7160 can be used in related research on glioblastoma.
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CD-10
0 ImagesCat. No.: HY-174395CD-10 is an orally active and BBB-penatrable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor. CD-10 binds to Keap1 with a KD value of 193 nM. CD-10 exhibits potent anti-oxidative and anti-inflammatory effects through Keap1-Nrf2 pathway activation, evidenced by reduced levels of MDA, IL-4, IL-10 and increased expression of HO-1. CD-10 effectively alleviated anxiety and depressive behaviors and restored serum neurotransmitter levels by promoting Nrf2 nuclear translocation in the chronic unpredictable mild stress (CUMS) mouse model. CD-10 can be used for the study of depression.
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IL-6-IN-3
0 ImagesCat. No.: HY-177281CAS No.: 601513-04-6IL-6-IN-3 (Example 4) is an IL-6 inhibitor with an IC50 of 0.4 nM. IL-6-IN-3 can be used for cancers like prostate cancer and arthritis like rheumatoid arthritis research.
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Cannabitwinol
0 ImagesCat. No.: HY-179432CAS No.: 2699950-81-5Synonyms: CBDDCannabitwinol is a selective thermosensitive TRP modulator and NF-κB inhibitor. Cannabitwinol inhibits TNFα-induced NF-κB-driven transcription and TNFα-induced IL-8 release, and exhibits anti-inflammatory and antioxidant activities. Cannabitwinol shows selectivity for cold-activated TRP channels, activating TRPA1 (EC50 = 3.0 μM) and antagonizing TRPM8 (IC50 = 3.9 μM), but has no significant affinity for heat-activated TRP channels such as TRPV1 and TRPV2. Cannabitwinol can be used in research related to inflammatory skin diseases, cold allodynia, and hyperalgesia.
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RTX-003
0 ImagesCat. No.: HY-P992029RTX-003 is a monoclonal antibody targeting CD25. RTX-003 induces the death of regulatory T cells (Tregs) by targeting the IL-2 receptor α chain (CD25), and can enhance anti-tumor immune responses.
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Truncated ADR58 sodium
0 ImagesCat. No.: HY-148695CADR58 sodium is a highly potent and selective human oncostatin M (OSM) antagonist, which can prevent the binding of OSM to the gp130 receptor and specifically antagonize OSM-mediated signaling. ADR58 sodium can be used in the research of rheumatoid arthritis related diseases.
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Lithocholic amide-C2-N(didecane)
0 ImagesCat. No.: HY-178721CAS No.: 2768690-22-6Lithocholic amide-C2-N(didecane) (Compound LC10) is a Lithocholic acid (HY-B0172) analogue. Lithocholic amide-C2-N(didecane) can form lipid nanoparticles spontaneously in the aqueous milieu, permeate through the skin, penetrate the deeper dermal layers, and exert anti-inflammatory effects against psoriasis-like chronic skin inflammations. Lithocholic amide-C2-N(didecane) can inhibit abnormal proliferation of keratinocytes, downregulate the mRNA expression of the psoriasis-associated receptor EphA2 and reduce serum levels of multiple pro-inflammatory factors such as IL-1α, IL-1β, and IFN-γ by inhibiting activation of the Th17/Th2 inflammatory pathway.
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BMS-986126
0 ImagesCat. No.: HY-124995CAS No.: 1610017-20-3BMS-986126 is a potent, selective, and orally active IRAK4 inhibitor (IC50 = 5.3 nM). BMS-986126 broadly inhibits MyD88-dependent signaling pathways. BMS-986126 demonstrates robust activity in the MRL/lpr and NZB/NZW murine models of lupus, inhibiting multiple pathogenic responses. BMS-986126 can be used for autoimmune diseases research, such as lupus erythematosus (SLE).
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DDO-6513
0 ImagesCat. No.: HY-W1150738CAS No.: 2809367-71-1DDO-6513 is a STING molecular glue inhibitor with an IC50 of 1.93 μM. DDO-6513 selectively targets human STING but not murine STING, and exhibits a Kd value of 151 nM for human STING. DDO-6513 induces aberrant head-to-head STING oligomerization and disrupts the formation of normal signal-competent linear STING polymers. DDO-6513 inhibits STING-dependent downstream activation of TBK1 and IRF3, and suppresses the expression of proinflammatory cytokines. DDO-6513 can be used for research on STING-related autoinflammatory diseases.
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Saquinavir-d9
0 ImagesCat. No.: HY-17007SCAS No.: 1356355-11-7Synonyms: Ro 31-8959-d9Saquinavir-d9 (Ro 31-8959-d9) is the deuterium labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
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4-Isopropylbenzyl alcohol (Standard)
0 Images(±)-Leucine (Standard) is the analytical standard of (±)-Leucine. This product is intended for research and analytical applications. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%.
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Theophylline-13C2,d6
0 ImagesCat. No.: HY-143683SCAS No.: 1782458-84-7Synonyms: 1,3-Dimethylxanthine-13C2,d6; Theo-24-13C2,d6Theophylline-13C2,d6 (1,3-Dimethylxanthine-13C2,d6) is the deuterium labeled and 13C-labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research.
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Anti-inflammatory agent 90
0 ImagesCat. No.: HY-163848CAS No.: 3053522-48-5Anti-inflammatory agent 90 (compound (R)-7) demonstrates decreasing of 32 % and 40 % for nitrite and IL-6, respectively in LPS-challenged RAW cells.
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AMY109
0 ImagesCat. No.: HY-P992035AMY109 is an anti-human interleukin-8 (IL-8) monoclonal antibody, with a Ka of 36.8 pM for human IL-8, and a Ka of 380 pM for cynomolgus monkey IL-8. AMY109 binds to human and cynomolgus monkey IL-8 in a pH-dependent manner, inhibits IL-8-mediated activation of CXCR1 and CXCR2, and blocks the downstream biological activities of IL-8. AMY109 inhibits neutrophil recruitment to endometriotic lesions and suppresses monocyte chemoattractant protein-1 production by neutrophils. AMY109 is applicable to research related to endometriosis.
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Glucocorticoid receptor/IL-6-IN-1
0 ImagesCat. No.: HY-176876CAS No.: 1198784-71-2Glucocorticoid receptor/IL-6-IN-1 (Compound 35) is a selective dual inhibitor targeting the glucocorticoid receptor (GR) and IL-6 signaling pathway (IC50 values of 120 nM and 59 nM, respectively). Glucocorticoid receptor/IL-6-IN-1 inhibits IL-6-induced JAK/STAT3 phosphorylation, blocking inflammatory cytokine transcription. Glucocorticoid receptor/IL-6-IN-1 is promising for research of inflammatory diseases like rheumatoid arthritis and asthma.
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NLRP3-IN-86
0 ImagesCat. No.: HY-180830CAS No.: 2361570-54-7NLRP3-IN-86 (Compound 8a), a derivative of Songorine (HY-N2080), is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-86 can reduce LPS (HY-D1056)- and Nigericin (HY-127019)-stimulated lactate dehydrogenase (LDH) release (IC50 = 2.69 μM in THP-1 cells and 1.75 μ M in J774A.1 cells). NLRP3-IN-86 can inhibit gasdermin D (GSDMD) cleavage and IL-1β secretion. NLRP3-IN-86 can inhibit cell pyroptosis. NLRP3-IN-86 can be used for research of inflammation.
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PF-07245303
0 ImagesCat. No.: HY-182335CAS No.: 2655556-75-3PF-07245303 is a ITK/TRK inhibitor. PF-07245303 reduces the production of inflammatory cytokines such as IL-4 and IFNγ, and inhibits the phosphorylation of PLCγ1. PF-07245303 inhibits nerve growth factor-induced basophil activation and the phosphorylation of TRKA. PF-07245303 reduces oxazolone-induced ear swelling in mouse ear tissues. PF-07245303 is applicable to research related to atopic dermatitis.
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PKR1 antagonist-2
0 ImagesCat. No.: HY-153201CAS No.: 910113-34-7PKR1 antagonist-2 is a non-peptide prokineticin receptor antagonist that preferentially binds to and blocks PK-R1 signaling while also blocking PK-R2. PKR1 antagonist-2 shifts the autoimmune response against myelin from a Th1/Th17 profile toward a Th2 profile, reducing myelin antigen-specific T cell proliferation and the production of proinflammatory cytokines (IFN-γ, TNF, IL-6, IL-17), and increasing the levels of anti-inflammatory cytokines IL-4/IL-10. PKR1 antagonist-2 significantly alleviates disease severity in relapsing-remitting and chronic experimental autoimmune encephalomyelitis (EAE). PKR1 antagonist-2 can be used in research related to multiple sclerosis .
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β5i-IN-2
0 ImagesCat. No.: HY-187220CAS No.: 3119216-05-3β5i-IN-2 is a potent, selective, and orally active inhibitor of the immunoproteasome β5i subunit, with an IC50 of 0.08 μM against human β5i. β5i-IN-2 inhibits LPS (HY-D1056)- and IFN-γ-induced expression of IL-1β, IL-6, and TNF-α, and suppresses the JNK, ERK, and NF-κB signaling pathways. β5i-IN-2 can be used in research related to rheumatoid arthritis and ulcerative colitis.
