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Dabrafenib

(Synonyms: GSK2118436A; GSK2118436)
83 Cited Publications
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Based on 83 publication(s) in Google Scholar

Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-RafV600E, respectively.

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  • Reinheit: 99.94%
  • CAS. Nr.: 1195765-45-7
  • Formel: C23H20F3N5O2S2
  • Molecular Weight:519.56
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Dabrafenib Chemical Structure
    Dabrafenib Chemical Structure
  • Experimental Validation Results for Dabrafenib
  • Experimental Validation Results for Dabrafenib
  • Experimental Validation Results for Dabrafenib
  • Experimental Validation Results for Dabrafenib
  • Experimental Validation Results for Dabrafenib
  • Experimental Validation Results for Dabrafenib
CAS. Nr.: 1195765-45-7
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  • Dabrafenib Chemical Structure
    Dabrafenib Chemical Structure
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    Dabrafenib purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Oct:146:157151. [Abstract]

    Customer Validation
     Dabrafenib (20 μM; 24-48 h). Cell viability is assessed using CCK-8 assays. Dabrafenib (Dab) is used to treat BRAFi-resistant melanoma cells [WM164-DR] for 24 or 48 hours.

  • 1/16

    Dabrafenib purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jun 3:e2400023. [Abstract]

    Customer Validation
     Inhibitory effects of Dabrafenib (40 µM; 24 h) on TRIM24 phosphorylation and protein interaction between TRIM24 and the DNA-PK complex in NHA/HRasV12/TRIM24 cells. Cells were treated with Dabrafenib for 24 h.

  • 1/16

    Dabrafenib purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 Mar 19;5(3):101471. [Abstract]

    Customer Validation
     Dabrafenib (30 mg/kg, p.o., 28 days). Relative tumor volumes and mice weights in sequential treatment groups with either vehicle or NEO2734 in A375 subcutaneous-bearing mice. Mice were switched to vehicle or NEO2734 treatment at day 28 (n = 6 for dabrafenib + trametinib to vehicle, n = 5 for dabrafenib + trametinib to NEO2734) (4 mg/kg NEO2734, 5 days/week; 30 mg/kg dabrafenib + 0.6 mg/kg trametinib daily).

  • 1/16

    Dabrafenib purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2020 Mar 16;37(3):387-402.e7. [Abstract]

    Customer Validation
     MCF-7 cells were seeded in 10-11 M E2 to which fulvestrant (F), dabrafenib (D), trametinib (T) or selumetinib (S) were subsequently added at 10-9, 10-6, 10-7 or 10-6 M, respectively. After 6 days, proteins were measured by immunoblotting, and phosphorylation levels (as defined by the levels of the phosphorylated form over total protein) relative to the vehicle-treated cells were set to 1.

  • 1/16

    Dabrafenib purchased from MedChemExpress. Usage Cited in: Cell Syst. 2020 Nov 18;11(5):478-494.e9. [Abstract]

    Customer Validation
     Dabrafenib (25 mg/kg; p.o.; 5 days). Immunofluorescence microscopy of pERK in A375 mouse xenografts treated either with vehicle alone or dabrafenib plus trametinib for 5 days.

  • 1/16

    Dabrafenib purchased from MedChemExpress. Usage Cited in: Int J Cancer. 2019 Mar 15;144(6):1379-1390. [Abstract]

    Customer Validation
     Western blot confirmed increased MAPK pathway activity in NEC-DUE2 cells when compared to NECDUE1. Treatment with PLX4032 (1 μM), Dabrafenib (100 nM), or GSK1120212 (100 nM) for 4 hours leads to decreased MAPK signaling in NEC-DUE2 cells. Lysates are immunoblotted for the proteins indicated.

  • Dabrafenib