Punicic acid
Based on 1 publication(s) in Google Scholar
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways.
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- Reinheit: 98.5%
- CAS. Nr.: 544-72-9
- Formel: C18H30O2
- Molecular Weight:278.43
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Speicherung:
Solution, -20°C, 2 years
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Punicic acid
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| FaDu | IC50 |
9 μM
Compound: Punicic acid
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Cytotoxicity against human FaDu cells assessed as reduction in cell growth measured after 24 hrs by MTT assay
Cytotoxicity against human FaDu cells assessed as reduction in cell growth measured after 24 hrs by MTT assay
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[PMID: 38306267] |
| HCT-116 | IC50 |
5 nM
Compound: Punicic acid
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 38306267] |
| HCT-116 | IC50 |
5 μM
Compound: 60; Pun A
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Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by presto blue reagent based analysis
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by presto blue reagent based analysis
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[PMID: 38142509] |
| T98G | IC50 |
9.85 μL/mL
Compound: 161
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Growth inhibition of human T98 GBM cells
Growth inhibition of human T98 GBM cells
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[PMID: 35786935] |
Punicic acid (10 μM, 4 min) inhibits TNF-α induced neutrophil ROS overproduction without affecting fMLP or PMA (HY-18739) induced responses[2]. Punicic acid (0-40 μM, 30 min) reduces TNF-α induced p47phox phosphorylation starting from 10 mM concentration[2]. Punicic acid (10 μM, 30 min) inhibits TNF-α induced NADPH oxidase activation[2]. Punicic acid (0-40 μM; 48 h) exhibits a concentration-dependent antiproliferative effect on MDA-ERα7 and MDA-wt cells[4]. Punicic acid (40 μM; 48 h) induces apoptosis of MDA-ERα7 and MDA-wt cells and increases the percentage of cells in the G2/M phase. The ability to induce apoptosis of MDA-ERα7 and MDA-wt cells is completely blocked in the presence of 20 μM α-tocotrienol (HY-129459)[4]. Punicic acid (5-80 μM; 48 h) is partially blocked in the presence of BIM (4 μM) on MDA-ERα7 and MDA-wt cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Neutrophils
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Concentration:0, 10, 20, 40 µM
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Incubation Time:30 min
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Result:Reduced TNFa-induced p47phox phosphorylation starting from 10 µM concentration. Inhibited p38MAPK phosphorylation at 20 µM similarly to p47phox inhibition of Ser345 phosphorylation, but almost no phospho-Ser345 and phosphoP38MAPK were detected.
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Cell Line:MDA-ERα7 and MDA-wt cells
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Concentration:40 µM
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Incubation Time:48 h
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Result:The apoptosis rate of BRCA cells is 86-91%.
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Cell Line:MDA-ERα7 and MDA-wt cells
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Concentration:0-40 µM
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Incubation Time:48 h
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Result:The proliferation rate of MDA-ERα7 was only 4.5%, while that of MDA-wt was 8.5% at a dose of 40 µM.
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Cell Line:MDA-ERα7 and MDA-wt cells
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Concentration:40 µM
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Incubation Time:48 h
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Result:The percent of MDA-ERα7 cells in the G2/M phase increased from 27.3 to 41.3% and the percent of MDA-wt cells in the G2/M phase increased from 12.3 to 20.3%.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:TNBS-induced Colitis male Wistar rat[1]
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Dosage:400 μg
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Administration:i.g.
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Result:Reduced the hyperactivation of neutrophils in the colon of TNBS-treated rats and inhibited the release of MPO and ROS by neutrophils, thereby reducing lipid peroxidation and tissue damage.
Chemical Information
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CAS. Nr. 544-72-9
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Appearance Liquid
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Molecular Weight 278.43
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Formel C18H30O2
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Color Colorless to light yellow
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SMILES
CCCC/C=C\C=C\C=C/CCCCCCCC(O)=O
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Synonyms
Trichosanic acid
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
Influence of vegetable oils and their constituents on in vitro human keratinocyte and fibroblast proliferation and migration. [Abstract]2025 Jul 24;15(1):26898. PMID: 40707519
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Shabbir MA, et al. Punicic acid: A striking health substance to combat metabolic syndromes in humans. Lipids Health Dis. 2017;16(1):99. [Content Brief]
[2]. Boussetta T, et al. Punicic acid a conjugated linolenic acid inhibits TNFα-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats[J]. PloS one, 2009, 4(7): e6458. [Content Brief]
[3]. Guerra-Vázquez, et al. Punicic acid and its role in the prevention of neurological disorders: A review. Foods 11.3 (2022): 252. [Content Brief]
[4]. Grossmann, et al. Punicic acid is an ω-5 fatty acid capable of inhibiting breast cancer proliferation. International journal of oncology 36.2 (2010): 421-426. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Punicic acid Related Classifications
HY-139066 Related Classifications
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