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Cat. No.: HY-146105

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Anticancer agent 65

Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC₅₀ of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells.

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CAS No.: 2407861-48-5
Formule: C₃₆H₆₃NO₅
Masse moléculaire:589.89

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Anticancer agent 65 Chemical Structure

CAS No.: 2407861-48-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
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Calculators
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Bioz

Activité biologique

Description

IC₅₀ & Target

MMP

Bcl-2

Bax

Voir tous les produits spécifiques à Isoform MMP :

Voir tous les produits spécifiques à Isoform Bcl-2 Family :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.07 μM Compound: 4c	Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
MCF7	IC₅₀	1.27 μM Compound: 4c	Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
MGC-803	IC₅₀	6.51 μM Compound: 4c	Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
PC-3	IC₅₀	5.44 μM Compound: 4c	Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
SGC-7901	IC₅₀	7.11 μM Compound: 4c	Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]

In Vitro

Anticancer agent 65 (compound 4c) increases the expression of Bax and decrease that of Bcl-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2407861-48-5
Masse moléculaire 589.89
Formule C₃₆H₆₃NO₅
SMILES

C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)OC(C5CCNCC5)=O)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@](C)(O)CCCC(C)(O)C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ma L, et al. Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives. Eur J Med Chem. 2020 Feb 1;187:111964. [Content Brief]

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1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Anticancer agent 65

Voir tous les produits spécifiques à Isoform MMP

Voir tous les produits spécifiques à Isoform Bcl-2 Family

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Anticancer agent 65 Related Classifications

HY-146105 Related Classifications