CDK7-IN-30
CDK7-IN-30 (Compound 22) is a CDK7 inhibitor (IC50 = 7.21 nM) that effectively inhibits the phosphorylation of RNA Polymerase II and CDK2. CDK7-IN-30 CDK7-IN-30 can induce cell apoptosis and has anti-cancer activity and can be used in cancer research.
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- CAS No.: 3040999-70-7
- Formule: C21H28ClN5O3S
- Masse moléculaire:466.00
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
|
CDK7 7.21 nM (IC50) |
RNA Polymerase |
CDK9 704.3 nM (IC50) |
CDK1 >10000.00 nM (IC50) |
CDK2 734.55 nM (IC50) |
CDK3 370.40 nM (IC50) |
CDK4 644.80 nM (IC50) |
CDK5 3678.50 nM (IC50) |
CDK6 1345.50 nM (IC50) |
CDK7-IN-30 (Compound 22) demonstrates potent antiproliferative effects on cancer cells, with IC50 values of 288.0 nM (RS4;11), 174.6 nM (MM.1S), 37.5 nM (Mino), and 168.7 nM (Jeko-1), respectively. Meanwhile, CDK7-IN-30 exhibits weaker inhibitory effects on normal blood cells PBMCs, with an IC50 value of 757.9 nM[1].
CDK7-IN-30 (50-500 nM; 24 h) causes cell cycle arrest in G1/S phase and (100-1000 nM; 48 h) promotes apoptosis in MV4-11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3040999-70-7
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Masse moléculaire 466.00
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Formule C21H28ClN5O3S
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SMILES
CC(C)S(C(C=CC=C1)=C1NC2=NC(N[C@@H]3CC[C@H](CC3)NC(C)=O)=NC=C2Cl)(=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK7-IN-30 Related Classifications
HY-163856 Related Classifications
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