MET - MET proto-oncogene, receptor tyrosine kinase Gene
Also Known as DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97
Species: Homo sapiens
About MET
This gene has 7 transcripts (splice variants), 207 orthologues, 53 paralogues and is associated with 163 phenotypes. Broad expression in placenta (RPKM 12.8), liver (RPKM 11.3) and 20 other tissues.
Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
MET Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001127500.3 | NP_001120972.1 | hepatocyte growth factor receptor isoform a preproprotein |
| NM_001324402.2 | NP_001311331.1 | hepatocyte growth factor receptor isoform d |
| XM_047420400.1 | XP_047276356.1 | hepatocyte growth factor receptor isoform X2 |
| XM_011516223.2 | XP_011514525.1 | hepatocyte growth factor receptor isoform X1 |
| NM_000245.4 | NP_000236.2 | hepatocyte growth factor receptor isoform b preproprotein |
| NM_001324401.3 | NP_001311330.1 | hepatocyte growth factor receptor isoform c precursor |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
16537482 | GOA |
| enables molecular function activator activity |
EXP
EXP: Inferred from Experiment
|
21247903 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
1846706 | GOA |
| enables protein phosphatase binding |
IPI
IPI: Inferred from physical interaction
|
18819921 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in basal plasma membrane |
IDA
IDA: Inferred from direct assay
|
15314156 | GOA |
MET Protein Structure
Sema: Sema domain (59 - 498)
PSI: Plexin repeat (520 - 561)
TIG: IPT/TIG domain (563 - 654)
TIG: IPT/TIG domain (657 - 728)
TIG: IPT/TIG domain (742 - 815)
Pkinase_Tyr: Protein tyrosine kinase (1078 - 1336)
- 0
- 300
- 600
- 900
- 1200
- 1390 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
hepatocyte growth factor receptor |
|
|
MET Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
MET | P08581 | KDR | Homo sapiens | P35968 | 22789536 | |
|
Intra
|
MET | P08581 | HGF | Homo sapiens | P14210 | 16537482 | |
|
Intra
|
MET | P08581 | HGF | Homo sapiens | P14210 | 17981115 | |
|
Intra
|
MET | P08581 | HGF | Homo sapiens | P14210 | 1846706 | |
|
Intra
|
MET | P08581 | HGF | Homo sapiens | P14210 | 17804794 | |
|
Intra
|
MET | P08581 | CBL | Homo sapiens | P22681 | 18273061 | |
|
Intra
|
MET | P08581 | CBL | Homo sapiens | P22681 | 21163258 | |
|
Intra
|
MET | P08581 | CBL | Homo sapiens | P22681 | 11894096 | |
|
Intra
|
MET | P08581 | CBL | Homo sapiens | P22681 | 21163258 | |
|
Intra
|
MET | P08581 | PREX1 | Homo sapiens | Q8TCU6 | 33061433 | |
|
Intra
|
MET | P08581 | PREX1 | Homo sapiens | Q8TCU6 | 33061433 | |
|
Intra
|
MET | P08581 | PLXNB1 | Homo sapiens | O43157 | 15184888 | |
|
Intra
|
MET | P08581 | PLXNB1 | Homo sapiens | O43157 | 12198496 | |
|
Intra
|
MET | P08581 | PLXNB1 | Homo sapiens | O43157 | 15184888 | |
|
Intra
|
MET | P08581 | PTPRB | Homo sapiens | P23467 | 16101282 | |
|
Cross
|
MET | P08581 | Hgf | Mus musculus | Q08048 | 17804794 | |
|
Cross
|
MET | P08581 | Hgf | Mus musculus | Q08048 | 17804794 | |
|
Intra
|
MET | P08581 | PTPRJ | Homo sapiens | Q12913 | 12475979 | |
|
Intra
|
MET | P08581 | PTPRJ | Homo sapiens | Q12913 | 12475979 | |
|
Intra
|
MET | P08581 | MUC1 | Homo sapiens | P15941 | 22962849 | |
|
Intra
|
MET | P08581 | EGFR | Homo sapiens | P00533 | 20624308 | |
|
Intra
|
MET | P08581 | PTPN11 | Homo sapiens | Q06124 | 18579758 | |
|
Intra
|
MET | P08581 | PLXNB3 | Homo sapiens | Q9ULL4 | 15184888 | |
|
Intra
|
MET | P08581 | PLXNB3 | Homo sapiens | Q9ULL4 | 15184888 | |
|
Intra
|
MET | P08581 | DNAJA3 | Homo sapiens | Q96EY1 | 35384245 | |
|
Intra
|
MET | P08581 | DNAJA3 | Homo sapiens | Q96EY1 | 21242965 | |
|
Intra
|
MET | P08581 | DNAJA3 | Homo sapiens | Q96EY1 | 21242965 | |
|
Intra
|
MET | P08581 | DNAJA3 | Homo sapiens | Q96EY1 | 35384245 | |
|
Intra
|
MET | P08581 | DNAJA3 | Homo sapiens | Q96EY1-2 | 21242965 | |
|
Intra
|
MET | P08581 | SRC | Homo sapiens | P12931 | 35405500 | |
|
Intra
|
MET | P08581 | SRC | Homo sapiens | P12931 | 20624308 | |
|
Intra
|
MET | P08581 | SRC | Homo sapiens | P12931 | 35405500 | |
|
Intra
|
MET | P08581 | SRC | Homo sapiens | P12931 | 24034250 | |
|
Intra
|
MET | P08581 | HGF | Homo sapiens | P14210-6 | 22897854 | |
|
Intra
|
MET | P08581 | PLXNB2 | Homo sapiens | O15031 | 15184888 | |
|
Intra
|
MET | P08581 | PTPN1 | Homo sapiens | P18031 | 16537444 | |
|
Intra
|
MET | P08581 | PTPN1 | Homo sapiens | P18031 | 18579758 | |
|
Intra
|
MET | P08581 | PTPN1 | Homo sapiens | P18031 | 22789536 | |
|
Cross
|
MET | P08581 | inlB | Listeria monocytogenes serovar 1/2a | P0DQD2 | 17662939 | |
|
Cross
|
MET | P08581 | inlB | Listeria monocytogenes serovar 1/2a | P0DQD2 | 17662939 | |
|
Cross
|
MET | P08581 | PTK2 | Gallus gallus | Q00944 | 20802513 | |
|
Cross
|
MET | P08581 | PTK2 | Gallus gallus | Q00944 | 20802513 |
Recombinant MET Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P70714 | HGFR Protein, Human (HEK293, His) | P08581-1 (E25-T932) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70715 | HGFR Protein, Human (HEK293, Fc) | P08581-1 (E25-T932) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72267 | HGFR Protein, Human (HEK293, hFc) | P08581-1 (E25-T932) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P72376 | HGFR Protein, Human (Biotinylated, HEK293, His-Avi) | P08581-1 (E25-T932) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72624 | HGFR Protein, Human (495a.a, HEK293, His) | P08581-1 (E25-G519) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72938 | HGFR Protein, Human (Active, sf9, His-GST) | P08581-1 (K956-S1390) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78490 | HGFR Protein, Human (HEK293, His-Avi) | P08581-1 (E25-T932) | ≥ 95%, as determined by Bis-Tris PAGE. |
MET Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P80219 | Met (C-Met) Antibody (YA298) | WB, IHC-P, ICC/IF, IF-Tissue | Human |
| HY-P80512 | Phospho-Met(c-Met) Antibody (YA175) | WB, IHC-P | Human |
| HY-P80803 | Phospho-Met(c-Met) (Tyr1349) Antibody (YA213) | WB, IP | Human |
| HY-P80803A | Phospho-Met(c-Met) (Tyr1349) Antibody (YA213)(PBS only) | WB, IP | Human |
| HY-P84014 | Met(c-Met) Antibody (YA3711) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Monkey |
| HY-P84014A | Met(c-Met) Antibody (YA3711)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Monkey |
| HY-P85883 | Met(c-Met) Antibody (YA5575) | WB, ICC/IF, ELISA | Human, Mouse, Rat, Monkey |
| HY-P86152 | Phospho-c-Met (Tyr1234/1235) Antibody (YA5844) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
| HY-P86238 | Met (C-Met) Antibody (YA5930) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hypopharynx Cancer |
|
|
| Sarcoma, Synovial |
|
|
| Barrett Esophagus |
|
|
| Sensorineural Hearing Loss |
|
|
| Breast Cancer |
|
|
| Salivary Gland Carcinoma |
|
|
| Esophageal Cancer |
|
|
| Lung Cancer |
|
|
| Lung Sarcomatoid Carcinoma |
|
|
| Hepatocellular Carcinoma |
|
|
| Von Hippel-Lindau Syndrome |
|
|
| Arthrogryposis, Distal, Type 1a |
|
|
| Thyroid Gland Anaplastic Carcinoma |
|
|
| Lung Benign Neoplasm |
|
|
| Adenocarcinoma |
|
|
| Rhabdomyosarcoma |
|
|
| Tall Cell Variant Papillary Carcinoma |
|
|
| Osteogenic Sarcoma |
|
|
| Chordoma |
|
|
| Cholangiocarcinoma |
|
|
| Vitreoretinopathy, Neovascular Inflammatory |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Follicular Adenoma |
|
|
| Non-Syndromic X-Linked Intellectual Disability |
|
|
| Autism 9 |
|
|
| Prostate Cancer |
|
|
| Bile Duct Cancer |
|
|
| Hereditary Renal Cell Carcinoma |
|
|
| Tumor Predisposition Syndrome |
|
|
| Malignant Peripheral Nerve Sheath Tumor |
|
|
| Ovarian Cancer |
|
|
| Gastroesophageal Adenocarcinoma |
|
|
| Breast Ductal Carcinoma |
|
|
| Pancreatic Cancer |
|
|
| Familial Renal Papillary Carcinoma |
|
|
| Gastroesophageal Junction Adenocarcinoma |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Atrophic Gastritis |
|
|
| Renal Cell Carcinoma, Papillary, 1 |
|
|
| Chondrosarcoma |
|
|
| Papillary Carcinoma |
|
|
| Sarcoma |
|
|
| Cataract 23, Multiple Types |
|
|
| Colorectal Cancer |
|
|
| Myeloma, Multiple |
|
|
| Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb |
|
|
| Gastric Adenocarcinoma |
|
|
| Acute Tympanitis |
|
|
| Inherited Cancer-Predisposing Syndrome |
|
|
| Glioblastoma |
|
|
| Retinoblastoma |
|
|
| Melanoma, Uveal |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Gastric Cancer |
|
|
| High Grade Glioma |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Kidney Cancer |
|
|
| Malignant Pleural Mesothelioma |
|
|
| Biliary Tract Cancer |
|
|
| Melanoma |
|
|
| Autism Spectrum Disorder |
|
|
| Autism |
|
|
| Inflammatory Myofibroblastic Tumor |
|
|
| Nervous System Disease |
|
|
| Mesothelioma, Malignant |
|
|
| Deafness, Autosomal Recessive 97 |
|
|
| Thyroid Gland Cancer |
|
|
| Medulloblastoma |
|
|
| Childhood Hepatocellular Carcinoma |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Occipital Lobe Neoplasm |
|
|
| Osteofibrous Dysplasia |
|
|
| Hepatoblastoma |
|
|
| Neural Tube Defects |
|
|
| Hypopharynx Cancer |
|
|
| Salivary Gland Carcinoma |
|
|
| Lung Sarcomatoid Carcinoma |
|
|
| Von Hippel-Lindau Syndrome |
|
|
| Vitreoretinopathy, Neovascular Inflammatory |
|
|
| Non-Syndromic X-Linked Intellectual Disability |
|
|
| Bile Duct Cancer |
|
|
| Papillary Carcinoma |
|
|
| Cataract 23, Multiple Types |
|
|
| Colorectal Cancer |
|
|
| Myeloma, Multiple |
|
|
| Acute Tympanitis |
|
|
| Retinoblastoma |
|
|
| Kidney Cancer |
|
|
| Biliary Tract Cancer |
|
|
| Autism Spectrum Disorder |
|
|
| Nervous System Disease |
|
|
| Medulloblastoma |
|
|
| Osteofibrous Dysplasia |
|
|
| Sarcoma, Synovial |
|
|
| Barrett Esophagus |
|
|
| Esophageal Cancer |
|
|
| Lung Cancer |
|
|
| Thyroid Gland Anaplastic Carcinoma |
|
|
| Adenocarcinoma |
|
|
| Tall Cell Variant Papillary Carcinoma |
|
|
| Osteogenic Sarcoma |
|
|
| Familial Renal Papillary Carcinoma |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Malignant Pleural Mesothelioma |
|
|
| Mesothelioma, Malignant |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Hepatoblastoma |
|
|
| Sensorineural Hearing Loss |
|
|
| Hepatocellular Carcinoma |
|
|
| Arthrogryposis, Distal, Type 1a |
|
|
| Lung Benign Neoplasm |
|
|
| Follicular Adenoma |
|
|
| Autism 9 |
|
|
| Hereditary Renal Cell Carcinoma |
|
|
| Pancreatic Cancer |
|
|
| Gastroesophageal Junction Adenocarcinoma |
|
|
| Atrophic Gastritis |
|
|
| Chondrosarcoma |
|
|
| Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb |
|
|
| Inherited Cancer-Predisposing Syndrome |
|
|
| Glioblastoma |
|
|
| Melanoma, Uveal |
|
|
| Gastric Cancer |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Autism |
|
|
| Inflammatory Myofibroblastic Tumor |
|
|
| Thyroid Gland Cancer |
|
|
| Childhood Hepatocellular Carcinoma |
|
|
| Breast Cancer |
|
|
| Rhabdomyosarcoma |
|
|
| Chordoma |
|
|
| Cholangiocarcinoma |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Prostate Cancer |
|
|
| Tumor Predisposition Syndrome |
|
|
| Malignant Peripheral Nerve Sheath Tumor |
|
|
| Ovarian Cancer |
|
|
| Gastroesophageal Adenocarcinoma |
|
|
| Breast Ductal Carcinoma |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Renal Cell Carcinoma, Papillary, 1 |
|
|
| Sarcoma |
|
|
| Gastric Adenocarcinoma |
|
|
| High Grade Glioma |
|
|
| Melanoma |
|
|
| Deafness, Autosomal Recessive 97 |
|
|
| Occipital Lobe Neoplasm |
|
|
| Neural Tube Defects |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | MET | MGD | MGI:96969 |
| Canis familiaris | MET | VGNC | VGNC:43166 |
| Rattus norvegicus | MET | RGD | RGD:3082 |
| Macaca mulatta | MET | VGNC | VGNC:81472 |
| Felis catus | MET | VGNC | VGNC:82444 |
| Bos taurus | MET | VGNC | VGNC:31394 |
| Others | MET | NCBI |