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Edaravone

(Synonyms: MCI-186)
48 Cited Publications
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Based on 48 publication(s) in Google Scholar

Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

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  • Reinheit: 99.94%
  • CAS. Nr.: 89-25-8
  • Formel: C10H10N2O
  • Molecular Weight:174.20
  • Speicherung:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Edaravone Chemical Structure
    Edaravone Chemical Structure
  • Experimental Validation Results for Edaravone
  • Experimental Validation Results for Edaravone
  • Experimental Validation Results for Edaravone
  • Experimental Validation Results for Edaravone
  • Experimental Validation Results for Edaravone
  • Experimental Validation Results for Edaravone
CAS. Nr.: 89-25-8
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  • Edaravone Chemical Structure
    Edaravone Chemical Structure
    1/16
  • 1/16

    Edaravone purchased from MedChemExpress. Usage Cited in: Int Wound J. 2023 Oct;20(8):3088-3104. [Abstract]

    Customer Validation
     Edaravone (EDA; 20.0 mg/kg/day; i.p.; 7 days) significantly increases the protein expression of TGF-β1, VEGF and MMP9 in mice.

  • 1/16

    Edaravone purchased from MedChemExpress. Usage Cited in: Int Wound J. 2023 Oct;20(8):3088-3104. [Abstract]

    Customer Validation
     Edaravone (EDA; 20.0 mg/kg/day; i.p.; 7 days) significantly reduces the number of apoptotic cells in mice.

  • 1/16

    Edaravone purchased from MedChemExpress. Usage Cited in: Int Wound J. 2023 Oct;20(8):3088-3104. [Abstract]

    Customer Validation
     Edaravone (EDA; 20.0 mg/kg/day; i.p.; 7 days) significantly promotes VEGF and MMP9 expression in mice.

  • 1/16

    Edaravone purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Jan 15:10:1596. [Abstract]

    Customer Validation
     After treating C2C12 cells with 250 µM H2O2, viability is significantly decreased, and improvement in survival rate was observed in the group treated with Edaravone at 100 µM (∗compared with 0 µM H2O2, p < 0.01; # compared with 250 µM H2O2, p < 0.01).

  • 1/16

    Edaravone purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Jan 15:10:1596. [Abstract]

    Customer Validation
     TNF-α expression is significantly increased by treating C2C12 cells with 250 µM H2O2. In addition, pretreatment with edaravone at 100 µM, TNF-α expression is significantly suppressed (∗ compared with 0 µM H2O2, p < 0.01; # compared with 250 µM H2O2, p < 0.01).

  • 1/16

    Edaravone purchased from MedChemExpress. Usage Cited in: Front Physiol. 2020 Jan 15:10:1596. [Abstract]

    Customer Validation
     A) HE staining of muscle tissue after artery ligation shows that the cells are round, and reveals infiltration of inflammatory cells in both control (Con) and ob/ob (Ob) mice. (B) MyoD immunostaining is lower in Ob than Con at 7 days after ligation of the femoral artery. However, pretreatment with Edaravone increases the expression of MyoD in obese mice.

  • Edaravone