AC-P19M
AC-P19M is an anticancer peptide. AC-P19M induces apoptosis by disrupting the cell membrane of cancer cells. AC-P19M reverses epithelial-mesenchymal transition (EMT). AC-P19M shows anti-angiogenic activity through the inhibition of VEGF-VEGFR2/ERK/Akt signaling. AC-P19M can be used for lung cancer research.
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- Formel: C102H186N26O20
- Molecular Weight:2096.73
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
AC-P19M (0.1-100 μM, 24 h) shows potent anticancer activity against lung cancer cells (A549 and H460), while showing low toxicity towards normal (BEAS-2B) and red blood cells[1].
AC-P19M (0.1-100 μM, 6 h) induces lactate dehydrogenase (LDH) release in A549 and H460 cells, indicating that it disrupts cell membranes, leading to cell death[1].
AC-P19M (2-10 μM, 24 h) induces cell apoptosis in A549 and H460 cells through the Bcl-2/Bax/caspase 3 cascade[1].
AC-P19M (0.2-0.5 μM, 24 h) inhibits the migration and invasion of A549 and H460 cells by reversing mesenchymal properties and the expression of EMT markers, ultimately inhibiting EMT process[1].
AC-P19M (10 μM, 12 h) exhibits an anti-angiogenic effect by contributing to the reduction of tubular morphology in human umbilical vein endothelial cells (HUVECs), while inhibiting VEGF-VEGFR2/ERK/Akt signaling[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 and H460 cells
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Concentration:0.2, 0.5, 2, 5, and 10 μM
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Incubation Time:24 h
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Result:Significantly decreased Bcl-2 levels, showing almost no expression at 10 μM.
Upregulated Bax protein levels to 2.5-fold in a concentration-dependent manner.
Resulted in a more than 2-fold increase of caspase 3.
Increased the expression levels of E-cadherin, while decreased the expression levels of N-cadherin and vimentin.
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Cell Line:A549 and H460 cells
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Concentration:0.2 and 0.5 μM
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Incubation Time:24 h
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Result:Inhibited cell migration by more than 20% in both A549 and H460 cells.
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Cell Line:A549 and H460 cells
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Concentration:0.2 and 0.5 μM
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Incubation Time:24 h
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Result:Inhibited cell invasion by more than 20% in both A549 and H460 cells.
Chemical Information
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Molecular Weight 2096.73
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Formel C102H186N26O20
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Sequence
Phe-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Lys-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Leu-Ala-Leu
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Sequence Shortening
FAKKLAKLKKKLAKLALA
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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