GLP1R - glucagon like peptide 1 receptor Gene

Also Known as GLP-1; GLP-1R; GLP-1-R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2740

About GLP1R

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,048,781-39,091,303 (from NCBI)

This gene has 1 transcript (splice variant), 127 orthologues and 42 paralogues. Biased expression in heart (RPKM 1.0), brain (RPKM 1.0) and 10 other tissues.

Summary

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced Insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to Insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

GLP1R Products (1)

mRNA Protein Name
NM_002062.5 NP_002053.3 glucagon-like peptide 1 receptor precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glucagon-like peptide 1 receptor activity IDA
IDA: Inferred from direct assay
28514449 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
28514449 GOA
involved in cAMP-mediated signaling IDA
IDA: Inferred from direct assay
7589461 GOA
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
7589461 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
28514449 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLP1R Protein Structure

HRM

HRM: Hormone receptor domain (60 - 127)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (144 - 398)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 463 a.a.
Protein Preferred Names Protein Names

glucagon-like peptide 1 receptor

  • GLP-1 receptor

GLP1R Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GLP1R P43220 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
GLP1R P43220 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
GLP1R P43220 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
GLP1R P43220 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
Intra
GLP1R P43220 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
GLP1R P43220 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
GLP1R P43220 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
GLP1R P43220 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
GLP1R P43220 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
GLP1R P43220 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
GLP1R P43220 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra
GLP1R P43220 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra
GLP1R P43220 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra
GLP1R P43220 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
GLP1R P43220 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
GLP1R P43220 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
GLP1R P43220 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
GLP1R P43220 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
GLP1R P43220 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
GLP1R P43220 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
GLP1R P43220 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
GLP1R P43220 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GLP1R Proteins

Cat. No. Product Name Accession Purity
HY-P70352 GLP1R Protein, Human (HEK293, Fc) P43220 (R24-Y145) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700468 GLP1R Protein, Human (HEK293, N-His, C-Myc) P43220 (R24-Y145) ≥ 95%, as determined by reducing SDS-PAGE.

GLP1R Antibodies

Cat. No. Product Name Application Reactivity
HY-P811065 GLP-1 Receptor Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Insulinoma

  • Islet Cell Adenoma

  • Insulin-Producing Tumor Of Islet Cells

  • Adenoma Islet Cell

  • Islet Cell Tumor

  • Experimental Organism Islet Cell Adenoma Neoplasm
Hyperglycemia
Hypoglycemia

  • Hypoglycaemia

  • Low Blood Sugar

  • Hypoglycaemia Nos

  • Spontaneous Hypoglycaemia

  • Nondiabetic Hypoglycaemia

  • Hypoglycaemic Disorder Nos

  • Hypoglycaemic Syndrome
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Glucose Intolerance

  • Glucose: Intolerance

  • Glucose: Malabsorption

  • Malabsorption Of Glucose

  • Impaired Glucose Tolerance
Pancreatic Cystadenoma

  • Cystadenoma Of Pancreas
Diabetes Mellitus, Ketosis-Prone

  • Diabetic Ketoacidosis

  • KPD

  • Diabetes Mellitus, Ketosis-Prone, Susceptibility To

  • Ketosis-Prone Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetic Ketoacidosis Nos

  • Dka - [Diabetic Ketoacidosis] Nos

  • Dka - [Diabetic Ketoacidosis] Without Coma

  • Dka - [Diabetic Ketoacidosis] With Coma
Diabetes Mellitus

  • Diabetes
Hyperinsulinism

  • Hyperinsulinemia
Prediabetes Syndrome

  • Prediabetes

  • Impaired Glucose Tolerance

  • Prediabetic State

  • IGT

  • Igt - [Impaired Glucose Tolerance]

  • Impaired Glucose Tolerance With Unspecified Complication

  • Impaired Glucose Tolerance Without Complication

  • Abnormal Glucose Tolerance
Hyperinsulinemic Hypoglycemia

  • Nesidioblastosis

  • Islet Cell Hyperplasia

  • Persistent Hyperinsulinemia Hypoglycemia Of Infancy

  • Hyperinsulinemic Hypoglycaemia
Leptin Deficiency Or Dysfunction

  • Morbid Obesity

  • Obesity Due To Congenital Leptin Deficiency

  • LEPD

  • Congenital Leptin Deficiency

  • Obesity, Morbid

  • Obesity, Morbid, Due To Leptin Deficiency

  • Severe Obesity

  • Obesity, Morbid, Nonsyndromic 1

  • Leptin Deficiency

  • Obesity, Severe, Due To Leptin Deficiency

  • Leptin

  • Morbid Obesity Due To Leptin Deficiency

  • Obesity Morbid

  • Leptin Dysfunction
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Intrahepatic Gall Duct Cancer

  • Malignant Neoplasm Of Intrahepatic Bile Ducts

  • Malignant Neoplasm Of Intrahepatic Gall Duct

  • Ca Intrahepatic Bile Ducts

  • Malignant Neoplasm Of Intrahepatic Biliary Passages

  • Intrahepatic Bile Duct Carcinoma
Dipsogenic Diabetes Insipidus

  • Primary Polydipsia

  • Doid:0081058

  • Psychogenic Polydipsia
Glucose Metabolism Disease

  • Glucose Metabolism Disorders

  • Disorder Of Glucose Metabolism
Carbohydrate Metabolic Disorder

  • Inborn Errors Of Carbohydrate Metabolism

  • Disorder Of Carbohydrate Metabolism

  • Carbohydrate Metabolism, Inborn Errors

  • Disorder Of Carbohydrate Transport And Metabolism

  • Inborn Carbohydrate Metabolism Disorder

  • Inborn Carbohydrate Metabolic Disorder

  • Carbohydrate Metabolism Disorder

  • Carbohydrate Metabolism Disorders

  • Disorders Of Carbohydrate Metabolism

  • Congenital Disorders Of Carbohydrate Metabolism

  • Inherited Disorders Of Carbohydrate Metabolism
Cardiovascular System Disease

  • Abnormality Of The Cardiovascular System

  • Cardiovascular Disease

  • Disease Of Subdivision Of Hemolymphoid System

  • Disorder Of Cardiovascular System

  • Cardiovascular Diseases
Inherited Metabolic Disorder

  • Inborn Errors Of Metabolism

  • Inborn Metabolic Disorder

  • Inborn Metabolism Disorder

  • Metabolic Hereditary Disorder

  • Inborn Error Of Metabolism

  • Metabolism, Inborn Errors
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114118 Semaglutide 99.74% Unkown
HY-112185 Orforglipron Agonist 99.64% Unkown
HY-114118A Semaglutide TFA 99.74% Unkown
HY-114118B Semaglutide acetate 99.96% Unkown
HY-112185A Orforglipron hemicalcium hydrate Agonist 99.58% Unkown

Clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Phase
HY-P3375 Mazdutide Agonist 99.97% Phase 3
HY-164535 Maridebart cafraglutide 99.24% Phase 3
HY-P4146A Survodutide TFA Agonist 99.39% Phase 3
HY-P11672 Poterepatide Agonist 99.78% Phase 3
HY-P3506B Retatrutide acetate Agonist 99.69% Phase 3
HY-125824 Danuglipron Agonist 99.85% Phase 2
HY-153865 Lotiglipron Agonist 98.96% Phase 2
HY-P3291 Dapiglutide Agonist 98.52% Phase 2
HY-175701 CT-996 99.97% Phase 2
HY-177295 Naperiglipron 99.43% Phase 2
HY-145632 Pemvidutide Agonist 99.40% Phase 2
HY-P10018 Bamadutide Agonist 99.94% Phase 2
HY-172811 DA-302168S Agonist 98.01% Phase 2
HY-125824A Danuglipron tromethamine Agonist / Phase 2
HY-145458 PF-06954522 Agonist 99.70% Phase 1
HY-P10031 SAR441255 Agonist 99.84% Phase 1

Pre-clinical Phase

Bioactive Molecules (117)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3506 Retatrutide Agonist 99.96% Unkown
HY-P4146 Survodutide Agonist 99.99% Unkown
HY-121835 GLP-1R agonist 2 Agonist 99.57% Unkown
HY-101116 GLP-1R Antagonist 1 Antagonist 99.67% Unkown
HY-P3506A Retatrutide TFA Agonist 99.86% Unkown
HY-P10736A AMG133 peptide payload TFA Agonist 99.70% Unkown
HY-160734 Aleniglipron Agonist 99.88% Unkown
HY-45894 tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu Control 98.04% Unkown
HY-114118S3 Semaglutide-13C6,15N TFA 96.04% Unkown
HY-P10736 AMG133 peptide payload 99.94% Unkown
HY-142162 LSN3318839 Modulator 99.22% Unkown
HY-114118CP Semaglutide (crude) 77.53% Unkown
HY-143312 V-0219 Modulator 99.90% Unkown
HY-P10302A GLP-1R/GIPR agonist-1 (soduim) Agonist 98.24% Unkown
HY-116819 VU0453379 Modulator 98.0% Unkown
HY-153193 LSN3160440 Modulator 98.08% Unkown
HY-114118S Semaglutide-d8 99.88% Unkown
HY-P0264A Exendin(9-39) amide acetate Antagonist 99.41% Unkown
HY-163996 DD202-114 99.27% Unkown
HY-112679 GLP-1 receptor agonist 2 Agonist 98.70% Unkown
HY-145412 GLP-1 receptor agonist 7 Agonist 98.17% Unkown
HY-147623 GLP-1R agonist 10 Agonist 98.19% Unkown
HY-P3375A Mazdutide TFA Agonist 99.67% Unkown
HY-114118F4 Semaglutide-FITC Agonist 96.42% Unkown
HY-141840 GLP-1R modulator C5 Modulator 99.81% Unkown
HY-P10929 Fmoc-Lys(tBuO-Ara-Glu(AEEA-AEEA)-OtBu)-OH 99.31% Unkown
HY-P10019 Pegsebrenatide Agonist 95.50% Unkown
HY-141842 GLP-1R modulator L7-028 Modulator 99.47% Unkown
HY-P10716 Exendin-P5 Activator 96.32% Unkown
HY-148212 GLP-1R agonist 17 Agonist 99.82% Unkown
HY-P10031A SAR441255 TFA Agonist 99.93% Unkown
HY-114118S1 Semaglutide-d8 tetraTFA 99.87% Unkown
HY-13443F2 Exendin-4, Cy5 labeled 97.16% Unkown
HY-143312A V-0219 hydrochloride Modulator 99.39% Unkown
HY-143312E (S)-V-0219 hydrochloride Modulator 99.71% Unkown
HY-144034 GLP-1R agonist 3 Agonist 95.76% Unkown
HY-145632A Pemvidutide TFA Antagonist 98.03% Unkown
HY-141839 GLP-1R modulator C16 Modulator 98.67% Unkown
HY-143312D (R)-V-0219 hydrochloride Modulator 98.92% Unkown
HY-124803 GPCR modulator-1 Modulator / Unkown
HY-147625 GLP-1R agonist 12 Agonist 95.06% Unkown
HY-P4146B Survodutide sodium Agonist / Unkown
HY-116819A VU0453379 hydrochloride Modulator 99.0% Unkown
HY-144035 GLP-1R agonist 4 Agonist 98.26% Unkown
HY-147622 GLP-1R agonist 9 Agonist / Unkown
HY-P10302 GLP-1R/GIPR agonist-1 Agonist / Unkown
HY-RS05490 GLP1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-142162A (S,R)-LSN3318839 Control 98.25% Unkown
HY-145458A PF-06954522 citrate Agonist / Unkown
HY-153193A (1R)-LSN3160440 98.43% Unkown
HY-N2452 Cochinchinenin C Agonist / Unkown
HY-RS16631 Glp1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-138996 GLP-1 receptor agonist 8 Agonist / Unkown
HY-114118C Semaglutide sodium / Unkown
HY-129657 GLP-1 receptor agonist 4 Agonist / Unkown
HY-143312B (R)-V-0219 Modulator / Unkown
HY-143312C (S)-V-0219 Modulator / Unkown
HY-144033 GLP-1R agonist 1 Agonist / Unkown
HY-144133 GLP-1R agonist 5 Agonist / Unkown
HY-144134 GLP-1R agonist 6 Agonist / Unkown
HY-144135 GLP-1R agonist 7 Agonist / Unkown
HY-144136 GLP-1R agonist 8 Agonist / Unkown
HY-145156 CHU-128 Agonist / Unkown
HY-147626 GLP-1R agonist 13 Agonist / Unkown
HY-147627 GLP-1R agonist 14 Agonist / Unkown
HY-147628 GLP-1R agonist 15 Agonist / Unkown
HY-147629 GLP-1R agonist 16 Agonist / Unkown
HY-160031 GLP-1R agonist 19 Agonist / Unkown
HY-161915 GLP-1R agonist 23 Agonist / Unkown
HY-162306 GLP-1R agonist 18 Agonist / Unkown
HY-162433 GLP-1R agonist 41 Agonist / Unkown
HY-162434 GLP-1R agonist 42 Agonist / Unkown
HY-162435 GLP-1R agonist 20 Agonist / Unkown
HY-162436 GLP-1R agonist 21 Agonist / Unkown
HY-162437 GLP-1R agonist 22 Agonist / Unkown
HY-168481 GLP-1R agonist 27 Agonist / Unkown
HY-171302 GLP-1R/GIPR agonist-2 Agonist / Unkown
HY-171850 GLP-1R modulator-1 Agonist / Unkown
HY-171851 GLP-1R agonist 32 Agonist / Unkown
HY-172410 GLP-1R agonist 28 Agonist / Unkown
HY-172673 GLP-1R agonist 31 Agonist / Unkown
HY-172836S GLP-1 receptor agonist 17-d3 Agonist / Unkown
HY-173479 GLP-1R agonist 30 Agonist / Unkown
HY-176493 GLP-1R agonist 33 Agonist / Unkown
HY-176770 GLP-1R agonist 34 Agonist / Unkown
HY-178768 GLP-1R agonist 35 Antagonist / Unkown
HY-178769 GLP-1R agonist 36 Agonist / Unkown
HY-181709 TPM003 Agonist / Unkown
HY-182502 GLP-1R-agonist-43 Agonist / Unkown
HY-182580 HBK001 / Unkown
HY-182849 GLP-1R agonist 44 Agonist / Unkown
HY-183693 GLP-1 receptor agonist 21 Agonist / Unkown
HY-P0165B Taspoglutide acetate Agonist / Unkown
HY-P10337 OXM-7 Agonist / Unkown
HY-P10842 d-GLP-2 E33A Agonist / Unkown
HY-P11043 GEP44 / Unkown
HY-P11044 GEP12 Agonist / Unkown
HY-P11262 GUB021794 Agonist / Unkown
HY-P11275 TC4 Agonist / Unkown
HY-P11279 TC2 Agonist / Unkown
HY-P11487 UTG-4 Agonist / Unkown
HY-P11670 Linvixdutide Agonist / Unkown
HY-P11818 GIPR/GLP-1R/GCGR agonist-1 / Unkown
HY-P11945 NOTA-MAL-Cys39-Exendin-4 Ligand / Unkown
HY-P3506CP Retatrutide (crude) Agonist / Unkown
HY-P3539 Exendin-4 (3-39) / Unkown
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / Unkown
HY-P4386 (Asp28)-Exenatide Agonist / Unkown
HY-P5161 FC382K10W15 Agonist / Unkown
HY-P5161A FC382K10W15 TFA Agonist / Unkown
HY-W823500 GLP-1R agonist 39 98.37% Unkown
HY-162979 GLP-1R agonist 25 Agonist / Unkown
HY-168585 GLP-1R agonist 26 Agonist / Unkown
HY-172411 GLP-1R agonist 29 Agonist / Unkown
HY-180220 GLP-1R agonist 40 Agonist / Unkown
HY-180489 GLP-1R agonist 38 Agonist / Unkown
HY-RS23066 Glp1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990013 Gulgafafusp alfa Inhibitor 95.481% Unkown
HY-P991099 Anti-GLP1R Antibody Inhibitor 97.19% Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GLP1R VGNC VGNC:29410
Mus musculus GLP1R MGD MGI:99571
Macaca mulatta GLP1R VGNC VGNC:73072
Canis familiaris GLP1R VGNC VGNC:41266
Felis catus GLP1R VGNC VGNC:62586
Rattus norvegicus GLP1R RGD RGD:2703
Others GLP1R NCBI