SNX7886
Based on 1 Customer Validation
SNX7886 is a CDK8/CDK19 PROTAC degrader. SNX7886 promotes the ubiquitination and degradation of CDK8 and CDK19. SNX7886 also promotes the degradation of CCNC. SNX7886 can be used in cancer research.
(Pink: CDK8 and CDK19 ligand (HY-168683); Blue: Cereblon ligand (HY-131875); Black: linker).
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 2924557-42-4
- Formula: C52H59N9O7
- Molecular Weight:922.08
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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CDK8 |
CDK19 |
SNX7886 (30 nM-1 μM; 24 h) potently degrades CDK8, CDK19, and their binding partner CCNC in human embryonic kidney 293 cells, with maximal degradation observed at concentrations as low as 30 nM after 24 h of treatment[1].
SNX7886 (200 nM; 72 h) induces kinase-dependent transcriptomic changes in human embryonic kidney 293 cells, altering expression of 1435 high-confidence DEGs after 72 h of 200 nM treatment, with effects largely overlapping those of the CDK8/19 kinase inhibitor BI1347[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human embryonic kidney 293 cells
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Concentration:30 nM, 100 nM, 300 nM, 1 μM
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Incubation Time:24 h
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Result:Degraded CDK8 by up to 90% and CDK19 by up to 80%, with concurrent degradation of CCNC.
Maintained degradation of CDK8, CDK19, and CCNC at 100 nM, 300 nM, and 1 μM concentrations.
Chemical Information
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CAS No. 2924557-42-4
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Appearance Solid
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Molecular Weight 922.08
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Formula C52H59N9O7
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Color Light yellow to yellow
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SMILES
O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(NCCCC(NCCCCCCCCCCC(N4CCN(CC4)C(CN5N=CC(C6=CC=C(C7=C8C=CC=CC8=CN=C7)C=C6)=C5)=O)=O)=O)=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (108.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0845 mL | 5.4225 mL | 10.8450 mL | 27.1126 mL |
| 5 mM | 0.2169 mL | 1.0845 mL | 2.1690 mL | 5.4225 mL | |
| 10 mM | 0.1085 mL | 0.5423 mL | 1.0845 mL | 2.7113 mL | |
| 15 mM | 0.0723 mL | 0.3615 mL | 0.7230 mL | 1.8075 mL | |
| 20 mM | 0.0542 mL | 0.2711 mL | 0.5423 mL | 1.3556 mL | |
| 25 mM | 0.0434 mL | 0.2169 mL | 0.4338 mL | 1.0845 mL | |
| 30 mM | 0.0362 mL | 0.1808 mL | 0.3615 mL | 0.9038 mL | |
| 40 mM | 0.0271 mL | 0.1356 mL | 0.2711 mL | 0.6778 mL | |
| 50 mM | 0.0217 mL | 0.1085 mL | 0.2169 mL | 0.5423 mL | |
| 60 mM | 0.0181 mL | 0.0904 mL | 0.1808 mL | 0.4519 mL | |
| 80 mM | 0.0136 mL | 0.0678 mL | 0.1356 mL | 0.3389 mL | |
| 100 mM | 0.0108 mL | 0.0542 mL | 0.1085 mL | 0.2711 mL |
SNX7886 Related Classifications
HY-156366 Related Classifications
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