FAK-IN-22
FAK-IN-22 (Compound 26) is an inhibitor of FAK, JAK3, and Aurora B, with IC50 values of 50.94 nM, 9.99 nM, and 0.49 nM, respectively, effectively inhibiting tumor occurrence and metastasis in pancreatic ductal adenocarcinoma (PDAC). FAK-IN-22 effectively inhibits the proliferation of PANC-1 cells, with an IC50 value of 0.15 μM. FAK-IN-22 induces apoptosis and G2/M phase arrest in PANC-1 cells by inhibiting the FAK/PI3K/Akt signaling pathway.
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- No. CAS: 2703920-02-7
- Fòrmula: C21H16F3N5O2
- Peso molecular:427.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas Aurora Kinase
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Actividad biológica
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JAK3 9.99 nM (IC50) |
FAK 50.94 nM (IC50) |
Aurora B 0.49 nM (IC50) |
Chemical Information
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No. CAS 2703920-02-7
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Peso molecular 427.38
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Fòrmula C21H16F3N5O2
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SMILES
O=C(C1=CC=C(NC2=NC=C(C(F)(F)F)C(OC3=CC=CC4=C3C=CN4)=N2)C=C1)NC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAK-IN-22 Related Classifications
HY-168718 Related Classifications
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