TR-213
TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK). TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer.
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- CAS No.: 2980502-40-5
- Formule: C22H20N4O3
- Masse moléculaire:388.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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RNA Polymerase |
TR-213 (0.1-10 μM, 6 h) potently degrades Cyclin K and CDK12 (56% and 91% degradation at 1 μM, respectively), inhibits the phosphorylation of Ser2 site in RNA polymerase II and regulates alternative polyadenylation activity in A549 and U2OS cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2980502-40-5
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Masse moléculaire 388.42
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Formule C22H20N4O3
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SMILES
N#CC1=CC=CC(C2=CCN(CC2)C3=NC(C4=CC(OC)=C(C=C4N3)OC)=O)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TR-213 Related Classifications
HY-177743 Related Classifications
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